Cellular Abnormalities and Reduced Colony-Forming Cells in Chronic Neutrophilic Leukaemia

Mehrotra, Purvi; Winfield, D.A.; Fergusson, L.H.

doi:10.1159/000206273

Cited by 21 publications

(22 citation statements)

References 13 publications

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“…63 A review of the CNL literature suggested that cytogenetic abnormalities occur in approximately a third of cases, with del(20q) being the most frequent finding. 62,64 Other reported abnormalities include trisomy 8, 65 trisomy 21 66 and t(1;20), 67 although none are specific for CNL. A normal karyotype, however, characterizes the majority of cases, a finding that suggests that the initial genetic event is submicroscopic and not visible by conventional cytogenetic analysis.…”

Section: Chronic Neutrophilic Leukaemiamentioning

confidence: 99%

Pathogenetic insight and prognostic information from standard and molecular cytogenetic studies in the BCR-ABL-negative myeloproliferative neoplasms (MPNs)

Reilly

2008

Leukemia

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The frequency of cytogenetic abnormalities in the Philadelphianegative myeloproliferative neoplasms (MPNs) varies from approximately 30% in primary myelofibrosis (PMF) to less than 5% in essential thrombocytosis (ET). The spectrum of aberrations is heterogeneous, ranging from gains and losses of genetic material to structural changes including unbalanced translocations. However, no specific abnormality has been identified to date. Nevertheless, such investigations can provide evidence of clonality and, as a result, cytogenetic findings have been included in the WHO diagnostic criteria for this group of diseases. The aim of the current review is to discuss the pathogenetic insight and prognostic information that standard, as well as molecular cytogenetic analysis has provided. A brief overview is given of the cytogenetic findings in the individual diseases, followed by a more detailed discussion of the possible pathogenetic consequences of specific abnormalities and their impact on prognosis.

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Section: Chronic Neutrophilic Leukaemiamentioning

confidence: 99%

Pathogenetic insight and prognostic information from standard and molecular cytogenetic studies in the BCR-ABL-negative myeloproliferative neoplasms (MPNs)

Reilly

2008

Leukemia

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“…These findings suggest that at least in some CNL cases oncogenesis occurs at the level of hematopoietic stem cells [4]. On the other hand, it has also been suggested from the results of clonal cell assays that CNL occurs at the level of granulocyte-committed progenitors [5, 6]. We present here a case of CNL that subsequently transformed to acute myeloblastic leukemia (AML) with dysplastic features in the granulocytic lineage and myelofibrosis.…”

Section: Introductionmentioning

confidence: 84%

Evolution to Acute Myeloblastic Leukemia from Chronic Neutrophilic Leukemia with Dysplastic Features in Granulocytic Lineage

Ota¹,

Tanaka

Kobayashi

et al. 2000

Acta Haematol

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We experienced the case of an 82-year-old man with chronic neutrophilic leukemia (CNL) with dysplastic features in the granulocytic lineage which subsequently progressed to acute myeloblastic leukemia (AML) with myelofibrosis. The patient had hepatosplenomegaly, but there was no evident cause of neutrophilic leukocytosis. The cytogenetic study showed that he had a normal karyotype. Concentrations of the serum granulocyte colony-stimulating factor (G-CSF) were not detectable. Two years after the diagnosis of CNL, blastic transformation to AML occurred with myelofibrosis and significant morphological abnormalities in neutrophils. The blasts were positive for myeloperoxidase, CD33, CD34, and HLA-DR, and the presence of dysplasia within the granulocytic lineage suggested that he had an abnormality at the level of the granulocyte-committed progenitors. Heterogeneous origins of CNL might lead to various clinicopathological features in each case.

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“…In addition, a series of case reports demonstrated severe bleeding complications in CNL patients (7,8), which suggests that CNL is correlated with increased bleeding; however, the precise pathological mechanism of this relationship remains unclear. Elliott suggested that the bleeding complications observed in patients with CNL are associated with treatment-induced thrombocytopenia (6); however, some case reports have indicated the presence of platelet dysfunction in these patients (7,(9)(10)(11)(12). The majority of CNL patients presenting with platelet dysfunction were reported before the establishment of the WHO 2008 diagnostic criteria for CNL.…”

Section: Discussionmentioning

confidence: 99%

A <i>CSF3R</i> T618I Mutation in a Patient with Chronic Neutrophilic Leukemia and Severe Bleeding Complications

2016

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Chronic neutrophilic leukemia (CNL) is a rare form of myeloproliferative neoplasm characterized by the drastic elevation of mature neutrophils. One of the major causes of death among patients with CNL is severe bleeding; however, the difficulty of accurately diagnosing this disease has caused confusion in this field. Recently, somatic mutations of the CSF3R gene have been associated with CNL. This has led to the establishment of more accurate diagnostic criteria for CNL. We herein report a case study of a patient with CNL with a T618I point mutation on the CSF3R gene who showed severe bleeding.

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Cellular Abnormalities and Reduced Colony-Forming Cells in Chronic Neutrophilic Leukaemia

Cited by 21 publications

References 13 publications

Pathogenetic insight and prognostic information from standard and molecular cytogenetic studies in the BCR-ABL-negative myeloproliferative neoplasms (MPNs)

Pathogenetic insight and prognostic information from standard and molecular cytogenetic studies in the BCR-ABL-negative myeloproliferative neoplasms (MPNs)

Evolution to Acute Myeloblastic Leukemia from Chronic Neutrophilic Leukemia with Dysplastic Features in Granulocytic Lineage

A <i>CSF3R</i> T618I Mutation in a Patient with Chronic Neutrophilic Leukemia and Severe Bleeding Complications

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