Cellular Aging and Restorative Processes: Subjective Sleep Quality and Duration Moderate the Association between Age and Telomere Length in a Sample of Middle-Aged and Older Adults

Cribbet, Matthew R.; Carlisle, McKenzie; Cawthon, Richard M.; Uchino, Bert N.; Williams, Paula; Smith, Timothy W.; Gunn, Heather E.; Light, Kathleen C.

doi:10.5665/sleep.3308

Cited by 81 publications

(73 citation statements)

References 49 publications

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“…Moreover, among those women for whom poor sleep quality was chronic, poorer sleep quality predicted shorter leukocyte telomere length. Additional work has extended these observations to older adults with assessment of sleep quality using a validated questionnaire (ie, Pittsburgh Sleep Quality Index, PSQI) and telomere length in peripheral blood mononuclear cells, and shown that age and self-reported sleep quality interact in predicting telomere length (Cribbet et al, 2014). Importantly, age was related to telomere length, and this association was more robust among poor sleepers.…”

Section: Sleep and Inflammaging: Experimental And Naturalistic Findingsmentioning

confidence: 94%

“…Importantly, age was related to telomere length, and this association was more robust among poor sleepers. Moreover, among older adults with good sleep quality, the association between age and telomere length was attenuated (Cribbet et al, 2014). further examined this question in older adults and evaluated differences in telomere in relation to diagnostic insomnia, and determined whether insomnia interacts with chronological age to increase cellular aging.…”

Section: Sleep and Inflammaging: Experimental And Naturalistic Findingsmentioning

confidence: 99%

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Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity

Irwin

Opp

2016

Neuropsychopharmacol

385

268

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Sleep disturbances including insomnia independently contribute to risk of inflammatory disorders and major depressive disorder. This review and overview provides an integrated understanding of the reciprocal relationships between sleep and the innate immune system and considers the role of sleep in the nocturnal regulation of the inflammatory biology dynamics; the impact of insomnia complaints, extremes of sleep duration, and experimental sleep deprivation on genomic, cellular, and systemic markers of inflammation; and the influence of sleep complaints and insomnia on inflammaging and molecular processes of cellular aging. Clinical implications of this research include discussion of the contribution of sleep disturbance to depression and especially inflammation-related depressive symptoms. Reciprocal action of inflammatory mediators on the homeostatic regulation of sleep continuity and sleep macrostructure, and the potential of interventions that target insomnia to reverse inflammation, are also reviewed. Together, interactions between sleep and inflammatory biology mechanisms underscore the implications of sleep disturbance for inflammatory disease risk, and provide a map to guide the development of treatments that modulate inflammation, improve sleep, and promote sleep health.

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Section: Sleep and Inflammaging: Experimental And Naturalistic Findingsmentioning

confidence: 94%

Section: Sleep and Inflammaging: Experimental And Naturalistic Findingsmentioning

confidence: 99%

Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity

Irwin

Opp

2016

Neuropsychopharmacol

385

268

View full text Add to dashboard Cite

show abstract

“…In addition, the authors show us that prevalence of insufficient sleep in adults has been estimated at 20% and the effects on cognitive processing are increased the risk of human-error-related accidents and poses risks to safe operation in all modes of transportation and to performance in other safety-sensitive activities. Cribbet et al, (2014) add that sleep privation has been found to introduce an increase on circulating levels of inflammatory markers, because sleep-wake cycle is an important factor to development of the immune system and the changes via too. Edelman, Kudzma and Mandle (2014), show us that a person with difficulties with sleep may be tense and irritable, unable to tolerate stress and incapable of making health-promoting relationships.…”

Section: Sleep Disorders and Sleep Deprivationmentioning

confidence: 98%

“…It can reduce productivity and absenteeism; these are the most widely reported work performance impairments. Thus, Cribbet et al (2014), explain inadequate sleep is associated with adverse health consequences as likely susceptibility to the common cold, metabolic syndrome and type two diabetes. Another study, Stein and Pu (2012), found the sleep disorders can has impact on cardiac autonomic control (arrhythmogenesis), which led to morbidity and mortality, among people who has pre-existing heart disease and/or sleep disorders breathing.…”

Section: Sleep Disorders and Sleep Deprivationmentioning

confidence: 99%

Aging and Sleep: Challenge to Nursing Practices

Pavani¹

2015

IJN

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The aging is normal life process, everybody one day will pass for this step, but what anybody know is that it leads to changes in the quantity and quality of sleep. This process affects more than half of adults, over 65 years old in the United States of America. These changes affect the sleep pattern, the psychological function, immune system, performance, behavioral response, humor and ability to adaptation.

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“…Many studies have extensively examined shortened leukocyte telomere lengths (LTL), induced by cellular aging, as a risk factor for various age-related diseases [5][6][7][8][9]. However, few have examined the association between telomere lengths (TL) and sleep quality [10][11][12]. Previous studies have been limited by only examining the association of LTL with a subjective sleep quality measure, Pittsburgh Sleep Quality Index (PSQI) [13].…”

Section: Introductionmentioning

confidence: 99%