Abstract:review the use of immobilized ligands for proteomic applications (affinity chromatography, chemical microarrays), including an excellent compilation of case studies in which the successful identification of the protein target of a bioactive small molecule illuminated the underlying biology. This chapter also provides numerous examples for reactive proteomics. A more in-depth coverage of this blossoming field, sometimes also called activity-based protein profiling, would have been well within the scope of this … Show more
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