Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology

Chuah, Candy; Jones, Malcolm K.; Burke, Melissa L.; McManus, Donald P.; Gobert, Geoffrey N.

doi:10.1016/j.pt.2013.12.009

Cited by 173 publications

(227 citation statements)

References 96 publications

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“…Schistosomiasis-induced liver fibrosis is mainly caused by SEA, an antigen that induces the production of IL-13 (but not TGF-␤) as a starting signal (25). IL-13 combines with the receptors (IL-13R␣1/IL-4R␣) on hepatic stellate cells, and then the JAK-STAT6 pathway and the M2 macrophage alternative activation pathway are activated, with excess collagen deposition (26).…”

Section: Discussionmentioning

confidence: 99%

Antischistosomiasis Liver Fibrosis Effects of Chlorogenic Acid through IL-13/miR-21/Smad7 Signaling Interactions In Vivo and In Vitro

Wang

Yang

Xue

et al. 2017

Antimicrob Agents Chemother

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Section: Discussionmentioning

confidence: 99%

Antischistosomiasis Liver Fibrosis Effects of Chlorogenic Acid through IL-13/miR-21/Smad7 Signaling Interactions In Vivo and In Vitro

Wang

Yang

Xue

et al. 2017

Antimicrob Agents Chemother

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“…Various cytokines are released during different stages of a schistosome infection, reflecting the host immune response (84,250,251). Generally, in the early acute infection phase, predominated by the juvenile schistosomulum stage, a Th1 cell-mediated response is generated, which releases proinflammatory cytokines, including tumor necrosis factor alpha (TNF-␣), gamma interferon (IFN-␥), interleukin-1 (IL-1), and IL-2.…”

Section: Cytokinesmentioning

confidence: 99%

Advances in the Diagnosis of Human Schistosomiasis

et al. 2015

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SUMMARY Schistosomiasis is a major neglected tropical disease that afflicts more than 240 million people, including many children and young adults, in the tropics and subtropics. The disease is characterized by chronic infections with significant residual morbidity and is of considerable public health importance, with substantial socioeconomic impacts on impoverished communities. Morbidity reduction and eventual elimination through integrated intervention measures are the focuses of current schistosomiasis control programs. Precise diagnosis of schistosome infections, in both mammalian and snail intermediate hosts, will play a pivotal role in achieving these goals. Nevertheless, despite extensive efforts over several decades, the search for sensitive and specific diagnostics for schistosomiasis is ongoing. Here we review the area, paying attention to earlier approaches but emphasizing recent developments in the search for new diagnostics for schistosomiasis with practical applications in the research laboratory, the clinic, and the field. Careful and rigorous validation of these assays and their cost-effectiveness will be needed, however, prior to their adoption in support of policy decisions for national public health programs aimed at the control and elimination of schistosomiasis.

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“…Pathology is associated with the host CD4+ Th2 response, with IL-4 and IL-13 the dominant cytokines responsible . Chemokines and their receptors have also been shown to play an important role in the development of schistosome egg-induced granuloma formation (Chuah et al, 2014a). The transcriptional regulation of hepatic schistosomiasis japonica in mouse models has been investigated during the acute phase of granuloma formation (Burke et al, 2010a, b;Perry et al, 2011;Chuah et al, 2013); however less is known regarding the more chronic phases and the events that occur in the liver during recovery after parasite clearance.…”

Section: Introductionmentioning

confidence: 99%

Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica

Chuah

Jones

McManus

et al. 2016

International Journal for Parasitology

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.N., Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica, International Journal for Parasitology (2016), doi: http://dx.doi.org/10.1016/j.ijpara. 2015.12.004 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica ABSTRACTFor hepatic schistosomiasis the egg-induced granulomatous response and the development of extensive fibrosis are the main pathologies. We used a Schistosoma japonicum-infected mouse model to characterise the multi-cellular pathways associated with the recovery from hepatic fibrosis following clearance of the infection with the anti-schistosomal drug, praziquantel. In the recovering liver splenomegaly, granuloma density and liver fibrosis were all reduced. Inflammatory cell infiltration into the liver was evident, and the numbers of neutrophils, eosinophils and macrophages were significantly decreased. Transcriptomic analysis revealed the up-regulation of fatty acid metabolism genes and the identification of Peroxisome proliferator activated receptor alpha (PPAR-α) as the upstream regulator of liver recovery. The aryl hydrocarbon receptor signalling pathway which regulates xenobiotic metabolism was also differentially up-regulated. These findings provide a better understanding of the mechanisms associated with the regression of hepatic schistosomiasis.

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Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology

Cited by 173 publications

References 96 publications

Antischistosomiasis Liver Fibrosis Effects of Chlorogenic Acid through IL-13/miR-21/Smad7 Signaling Interactions In Vivo and In Vitro

Antischistosomiasis Liver Fibrosis Effects of Chlorogenic Acid through IL-13/miR-21/Smad7 Signaling Interactions In Vivo and In Vitro

Advances in the Diagnosis of Human Schistosomiasis

Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica

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