Cellular and exosomal GPx1 are essential for controlling hydrogen peroxide balance and alleviating oxidative stress in hypoxic glioblastoma

Lei, Fu-Ju; Chiang, Jung-Ying; Chang, Huan-Jui; Chen, Der-Cherng; Wang, Hwai-Lee; Yang, Horng Ren; Wei, Kuo Chen; Huang, Yun-Chen; Wang, Chi-Chung; Wei, Sung-Tai; Hsieh, Cheng-Hong

doi:10.1016/j.redox.2023.102831

Cited by 5 publications

(1 citation statement)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, HIF1α has been associated with the activation of Ror1 transcription to influence cancer progression [ 18 ], and it regulates miR-210-3p, CXCR7, CXCR4, IDH1, C-Met, SF/HGF, the S100A4/NMIIA axis, NO, VEGF, BAG3, and TDO2, and influences various aspects of the glioblastoma biology such as angiogenesis, invasion, metabolism and therapy resistance [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 30 , 31 , 32 , 33 , 34 ]. Similarly, HIF2α has been shown to regulate GPx1 to ensure resistance to oxidative stress and radiation [ 59 ], while contributing to glioblastoma progression via various mechanisms such as the DDX28-mediated regulation of eIF4E2-driven translation [ 49 ]. In addition, other factors such as miR-370-3p [ 61 ], NIX-mediated mitophagy [ 62 ], and p21 (CDKN1A)[ 63 ] have been identified as crucial players in glioblastoma pathogenesis, highlighting the complex interplay of genetic alterations in shaping the aggressive behavior of glioblastoma cells in the hypoxic tumor microenvironment.…”

Section: Resultsmentioning

confidence: 99%

Understanding the Significance of Hypoxia-Inducible Factors (HIFs) in Glioblastoma: A Systematic Review

Begagić,

Bečulić,

Džidić-Krivić

et al. 2024

Cancers

View full text Add to dashboard Cite

Background: The study aims to investigate the role of hypoxia-inducible factors (HIFs) in the development, progression, and therapeutic potential of glioblastomas. Methodology: The study, following PRISMA guidelines, systematically examined hypoxia and HIFs in glioblastoma using MEDLINE (PubMed), Web of Science, and Scopus. A total of 104 relevant studies underwent data extraction. Results: Among the 104 studies, global contributions were diverse, with China leading at 23.1%. The most productive year was 2019, accounting for 11.5%. Hypoxia-inducible factor 1 alpha (HIF1α) was frequently studied, followed by hypoxia-inducible factor 2 alpha (HIF2α), osteopontin, and cavolin-1. Commonly associated factors and pathways include glucose transporter 1 (GLUT1) and glucose transporter 3 (GLUT3) receptors, vascular endothelial growth factor (VEGF), phosphoinositide 3-kinase (PI3K)-Akt-mechanistic target of rapamycin (mTOR) pathway, and reactive oxygen species (ROS). HIF expression correlates with various glioblastoma hallmarks, including progression, survival, neovascularization, glucose metabolism, migration, and invasion. Conclusion: Overcoming challenges such as treatment resistance and the absence of biomarkers is critical for the effective integration of HIF-related therapies into the treatment of glioblastoma with the aim of optimizing patient outcomes.

show abstract

Section: Resultsmentioning

confidence: 99%

Understanding the Significance of Hypoxia-Inducible Factors (HIFs) in Glioblastoma: A Systematic Review

Begagić,

Bečulić,

Džidić-Krivić

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

Cu‐Doping Layered Double Hydroxides Nanozyme Integrated with Nitric Oxide Donor for Enhanced Antioxidant Therapy in Retinopathy

Xue,

Lu,

Wang

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

The prevalence of retinal neovascular diseases necessitates novel treatments beyond current therapies like laser surgery or anti‐VEGF treatments, which often carry significant side effects. A novel therapeutic approach is introduced using copper‐containing layered double hydroxides (Cu‐LDH) nanozymes integrated with nitric oxide‐releasing molecules (GSHNO), forming Cu‐LDH@GSHNO aimed at combating oxidative stress within the retinal vascular system. Combination of synthetic chemistry and biological testing, Cu‐LDH@GSHNO are synthesized, characterized, and assessed for curative effect in HUVECs and an oxygen‐induced retinopathy (OIR) mouse model. The results indicate that Cu‐LDH@GSHNO demonstrates SOD‐CAT cascade catalytic ability, accompanied with GSH and nitric oxide‐releasing capabilities, which significantly reduces oxidative cell damage and restores vascular function, presenting a dual‐function strategy that enhances treatment efficacy and safety for retinal vascular diseases. The findings encourage further development and clinical exploration of nanozyme‐based therapies, promising a new horizon in therapeutic approaches for managing retinal diseases driven by oxidative stress.

show abstract

Design strategies for enhancing antitumor efficacy through tumor microenvironment exploitation using albumin-based nanosystems: A review

Zhang,

Yang,

Yang

2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Cellular and exosomal GPx1 are essential for controlling hydrogen peroxide balance and alleviating oxidative stress in hypoxic glioblastoma

Cited by 5 publications

References 64 publications

Understanding the Significance of Hypoxia-Inducible Factors (HIFs) in Glioblastoma: A Systematic Review

Understanding the Significance of Hypoxia-Inducible Factors (HIFs) in Glioblastoma: A Systematic Review

Cu‐Doping Layered Double Hydroxides Nanozyme Integrated with Nitric Oxide Donor for Enhanced Antioxidant Therapy in Retinopathy

Design strategies for enhancing antitumor efficacy through tumor microenvironment exploitation using albumin-based nanosystems: A review

Contact Info

Product

Resources

About