Cellular and humoral immunity after vaccination or natural mumps infection

Terada, Kihei; Hagihara, Kimiko; Oishi, Tomohiro; Miyata, Ippei; Akaike, Hiroto; Ogita, Satoko; Ohno, Naoki; Ouchi, Kazunobu

doi:10.1111/ped.13306

Cited by 6 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, 7.8% showed a prevalence of antibodies to measles and rubella in the absence of mumps-specific antibodies. Therefore, previous measurement of anti-mumps-specific IgG that represented immunity induced by the mumps vaccine appears to be overestimated ( 99 , 213 ).…”

Section: Laboratory Determinants Of An Effective Immune Response To Mmentioning

confidence: 99%

“…de Wit et al (199,236,237) has shown the presence of Th1-type CD4 + T-cells recognizing a MuV epitope in a HLR-DR restricted manner. In addition, the response of IFN-γ and TNF producing CD8 + T-cells specific to MuV epitopes are lower in vaccinated individuals when compared to individuals who were naturally infected (199,213,(236)(237)(238). Utilizing current knowledge and new technologies may help define a better surrogate correlate of protection and potentially determine a cut-off between the immunity of a vaccinated individual and a secondary mumps infection.…”

Section: Is Lymphoproliferative Immunity a Better Correlate Of Protection?mentioning

confidence: 99%

See 1 more Smart Citation

Mumps Outbreaks in Vaccinated Populations—Is It Time to Re-assess the Clinical Efficacy of Vaccines?

Connell

Leahy

et al. 2020

Front. Immunol.

View full text Add to dashboard Cite

History illustrates the remarkable public health impact of mass vaccination, by dramatically improving life expectancy and reducing the burden of infectious diseases and co-morbidities worldwide. It has been perceived that if an individual adhered to the MMR vaccine schedule that immunity to mumps virus (MuV) would be lifelong. Recent mumps outbreaks in individuals who had received two doses of the Measles Mumps Rubella (MMR) vaccine has challenged the efficacy of the MMR vaccine. However, clinical symptoms, complications, viral shedding and transmission associated with mumps infection has been shown to be reduced in vaccinated individuals, demonstrating a benefit of this vaccine. Therefore, the question of what constitutes a good mumps vaccine and how its impact is assessed in this modern era remains to be addressed. Epidemiology of the individuals most affected by the outbreaks (predominantly young adults) and variance in the circulating MuV genotype have been well-described alluding to a collection of influences such as vaccine hesitancy, heterogeneous vaccine uptake, primary, and/or secondary vaccine failures. This review aims to discuss in detail the interplay of factors thought to be contributing to the current mumps outbreaks seen in highly vaccinated populations. In addition, how mumps diagnoses has progressed and impacted the understanding of mumps infection since a mumps vaccine was first developed, the limitations of current laboratory tests in confirming protection in vaccinated individuals and how vaccine effectiveness is quantified are also considered. By highlighting knowledge gaps within this area, this state-of-the-art review proposes a change of perspective regarding the impact of a vaccine in a highly vaccinated population from a clinical, diagnostic and public perspective, highlighting a need for a paradigm shift on what is considered vaccine immunity.

show abstract

Section: Laboratory Determinants Of An Effective Immune Response To Mmentioning

confidence: 99%

Section: Is Lymphoproliferative Immunity a Better Correlate Of Protection?mentioning

confidence: 99%

Mumps Outbreaks in Vaccinated Populations—Is It Time to Re-assess the Clinical Efficacy of Vaccines?

Connell

Leahy

et al. 2020

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Lower seroconversion rates and reduced magnitude of antibody response after vaccination compared to natural infection were observed in this systematic review and are consistent with literature data regarding other vaccines in general population. For instance, not only were the antibody titers generated by vaccination lower than those induced by natural mumps infection [ 42 ], but also the magnitude and duration of cell-mediated immunity were greater after rubella natural infection [ 43 ]. Finally, the safety and tolerability of the COVID-19 vaccination that emerged from this study are in accordance with previous results from adult KTRs [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Immunologic Response to SARS-CoV-2 Vaccination in Pediatric Kidney Transplant Recipients: A Systematic Review and Meta-Analysis

Emmanouilidou-Fotoulaki

Karava

Dotis

et al. 2023

Vaccines

View full text Add to dashboard Cite

The pediatric population is at a lower risk of severe SARS-CoV-2 infection compared to adults. Nevertheless, immunosuppression in pediatric and adolescent kidney transplant recipients (KTRs) increases their hazard compared to the general population. This systematic review evaluates the efficacy of SARS-CoV-2 vaccines and determines the risk factors of no seroconversion in this population. PubMed-MEDLINE databases were searched for cohort studies. A meta-analysis was performed using fixed and random effect models. In total, seven studies including 254 patients were further analyzed. The random effect model demonstrated a 63% seroconversion rate (95% CI 0.5, 0.76) following a two-dose schedule, which increased to 85% (95% CI 0.76, 0.93) after the third dose administration. Seropositivity was lower in patients under mycophenolate mofetil compared to azathioprine (OR 0.09, 95% CI 0.02, 0.43). Rituximab administration decreased the seroconversion rate (OR 0.12, 95% CI 0.03, 0.43). The glomerular filtration rate (GFR) was 9.25 mL/min/1.73 m2 lower (95% CI 16.37, 2.13) in patients with no seroconversion. The seroconversion rate was lower in vaccinated compared to infected patients (OR 0.13, 95% CI 0.02, 0.72). In conclusion, vaccination against SARS-CoV-2 in pediatric and adolescent KTRs elicits a humoral response, and a third dose is advised. Previous rituximab administration, antimetabolite therapy with mycophenolate mofetil and lower GFR reduce the likelihood for seroconversion.

show abstract

“…Our data had other important weaknesses. Natural infection induces a higher concentration of antibodies than vaccination does [ 22 , 31 ]. Antibody concentrations at one point in time reflect initial response, rate of decay, time since vaccination or infection, and probably other factors such as past diet, age, and recent infections or vaccinations with other antigens.…”

Section: Discussionmentioning

confidence: 99%

Serum Concentration of Antibodies to Mumps, but Not Measles, Rubella, or Varicella, Is Associated with Intake of Dietary Fiber in the NHANES, 1999–2004

Landingham¹,

Keast²,

Longnecker

2021

Nutrients

View full text Add to dashboard Cite

Treatment with prebiotics, a type of dietary fiber, was recently shown to increase antibody concentrations following influenza vaccination in a meta-analysis of clinical trials. In observational epidemiologic studies it is not possible to estimate intake of prebiotics, but quantifying intake of dietary fiber is routine. Our objective was to investigate the potential effect of dietary fiber on immunogenicity. We examined serum antibody concentrations (Measles, Mumps, Rubella, and Varicella) in relation to dietary fiber in more than 12,000 subjects in the U.S. National Health and Nutrition Examination Survey (NHANES) for the period 1999–2004. Data from one (1999–2002) or two (2003–2004) dietary recalls were used to calculate fiber intake. For Mumps the adjusted percentage difference in antibody concentration per interquartile range intake in energy-adjusted dietary fiber was 6.34% (95% confidence interval, 3.10, 9.68). Fiber from grain-based foods was more positively associated than fiber from other fiber-containing food groups. The association was slightly larger among subgroups with higher fiber intake, greater interquartile range in fiber intake, and less measurement error. Furthermore, based on the reliability of the diet recalls in 2003–2004, we calculated that the percentage difference per interquartile increment was substantially attenuated by measurement error. Dietary fiber may have a favorable influence on the immunogenicity of some vaccines or natural infections.

show abstract

Cellular and humoral immunity after vaccination or natural mumps infection

Abstract: Vaccination or even natural mumps infection did not always induce both cellular and humoral immunity.

Cited by 6 publications

References 29 publications

Mumps Outbreaks in Vaccinated Populations—Is It Time to Re-assess the Clinical Efficacy of Vaccines?

Mumps Outbreaks in Vaccinated Populations—Is It Time to Re-assess the Clinical Efficacy of Vaccines?

Immunologic Response to SARS-CoV-2 Vaccination in Pediatric Kidney Transplant Recipients: A Systematic Review and Meta-Analysis

Serum Concentration of Antibodies to Mumps, but Not Measles, Rubella, or Varicella, Is Associated with Intake of Dietary Fiber in the NHANES, 1999–2004

Contact Info

Product

Resources

About