Cellular and Molecular Aspects of the Antidiuretic Action of Vasopressins and Related Peptides

Schwartz, Irving L.; Livingston, Linda

doi:10.1016/s0083-6729(08)60341-6

Cited by 29 publications

(6 citation statements)

References 216 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It seems safe to say, however, in view of the identity of the P/O ratio found in R. cancrivora and in R. temporaria, that the neurohypophysis of R. cancrivora probably has peptides which are similar at least to those of the non-eturyhaline R. temporaria. If the assumption is made that the main hormone is 8-arginine vasotocin then, using the range of potencies quoted by Schwartz & Livingston (1964), it can be calculated that one pituitary of R. cancrivora has an oxytocic activity equivalent to from 0-01 to 0-07 Fug vasotocin, and a pressor activity equivalent to from 0-05 to 0-2 ,g vasotocin. Such calculations can however be tentative only.…”

Section: Discussionmentioning

confidence: 99%

Water uptake by the crab‐eating frog Rana cancrivora, as affected by osmotic gradients and by neurohypophysial hormones

Dicker¹,

Elliott²

1970

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. The rate of water uptake across the skin was investigated in live Rana cancrivora, an euryhaline frog which has been reported to tolerate sea water. When they were exposed to distilled water at 290 C, the rate of water uptake was 8 4 + 0 4 #tl./cm2. hr; when bathed in solutions ranging from 30 to 570 m-osmole/l., irrespective of whether the solute was sucrose, urea or NaCl, the rate of fluid uptake during the first day was inversely related to the osmolarity of the solution. No appreciable fluid movement was observed when the bathing solution had an osmolar concentration of 270 m-osmole/l.2. The rate of fluid uptake was not affected by injections of vasopressin, oxytocin or of extracts of amphibian or rat pituitary glands, irrespective of whether R. cancrivora were bathed in distilled water or in solutions of NaCl or sucrose.3. In Bufo melanostictus, in contrast with R. cancrivora, injections of neurohypophysial extracts produced a marked increase of the rate of fluid uptake.4. In the laboratory, R. cancrivora could be acclimatized stepwise to tolerate NaCl solutions up to 700 m-osmole/l. for 7 days.5. After 24 hr exposure either to distilled water or to NaCl solutions from 100 to 670 m-osmole/l., the osmolar concentration of the plasma of R. cancrivora was always higher than that of the bathing fluid. In R. pipiens or R. temporaria plasma osmolar concentration was higher than that of the bathing fluid only when the latter did not exceed 300 m-osmole/l.6. Under all conditions investigated, the osmolar concentration of the urine of R. cancrivora was always lower than that of the plasma.7. The amounts of pressor and oxytocic activities of pituitary glands of S. E. DICKER AND ANNIE B. ELLIOTT R. cancrivora kept in distilled water or in NaCl solutions up to 300 mosmole/l. were 8*9 + 0*8 and 1-8 + 0*3 m-u./gland, irrespective of sex or body weight within the range 30-50 g. After 3 days exposure to hypertonic NaCl solutions, the amounts of pressor and oxytocic activities were 14*7 + 1*2 and 3*1 + 0-3 m-u./gland. In both instances the pressor/oxytocic ratio was 4.9. Pituitary glands of R. temporaria similarly showed increased pressor and oxytocic activities after exposure to NaCl solutions of 300-360 m-osmole/l.

show abstract

Section: Discussionmentioning

confidence: 99%

Water uptake by the crab‐eating frog Rana cancrivora, as affected by osmotic gradients and by neurohypophysial hormones

Dicker¹,

Elliott²

1970

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…These analogues include I ,6-djenkolic acid oxytocin and I ,6-djenkolic acid-lysine vasopressin which have a methylene group interposed between the sulphur atoms in the disulphide bridge. The peptides activity is, however, much reduced and Schwartz & Livingston (1964) have suggested that the -S-Sgroup may be essential for maintaining the shape of the molecule and also may affect the hormone-receptor affinity. It may, for instance, facilitate the entry of the hormone into the cell.…”

Section: (G) Relationship Between Structure Of the Neurohypophysial Pmentioning

confidence: 99%

The Physiology of the Urinary Bladder of Amphibia

Bentley

1966

Biological Reviews

101

View full text Add to dashboard Cite

“…i.e., at pharmacological concentrations LysVP elicits the physiological responses characteristic of oxytocin and vice versa (5,6).…”

mentioning

confidence: 99%

Conformation of Lysine Vasopressin: A Comparison with Oxytocin

Walter

Glickson

Schwartz

et al. 1972

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Starting with assignments of proton nuclear magnetic resonance previously made for oxytocin in deuterated dimethylsulfoxide at 220 MHz, we have assigned resonances for the mammalian antidiuretic hormone, lysine vasopressin. The results demonstrate that spectral assignments of neurohypophyseal hormones and their congeners can, within certain limits, be derived from each other. Comparison of the spectra of lysine vasopressin and oxytocin suggests that the gross backbone conformations of their 20-membered ring components are for the most part similar in deuterated dimethylsulfoxide, whereas the C-terminal acyclic amino-acid sequence of lysine vasopressin is more flexible than that of oxytocin.

show abstract

Cellular and Molecular Aspects of the Antidiuretic Action of Vasopressins and Related Peptides

Cited by 29 publications

References 216 publications

Water uptake by the crab‐eating frog Rana cancrivora, as affected by osmotic gradients and by neurohypophysial hormones

Water uptake by the crab‐eating frog Rana cancrivora, as affected by osmotic gradients and by neurohypophysial hormones

The Physiology of the Urinary Bladder of Amphibia

Conformation of Lysine Vasopressin: A Comparison with Oxytocin

Contact Info

Product

Resources

About