Cellular and molecular biology of sirtuins in cardiovascular disease

Liu, Yongping; Wen, Ri; Liu, Chunfeng; Zhang, Tie-Ning; Yang, Ni

doi:10.1016/j.biopha.2023.114931

Cited by 10 publications

(4 citation statements)

References 205 publications

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“…In addition, Sundaresan et al found that SIRT6 knockdown can enhance histone H3 lysine 9 (H3K9) acetylation and c-Jun promoter transcriptional activity, resulting in the over-activation of a variety of IGF signaling related genes. These results indicate that SIRT6 can negatively regulate IGF-Akt signaling pathway and reduce myocardial hypertrophy and myocardial fibrosis [ 58 ]. The differentiation of cardiac fibroblasts into myofibroblasts represents a key event in cardiac fibrosis and contributes to pathological cardiac remodeling.…”

Section: Fibrosismentioning

confidence: 99%

SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging

Wei,

Li,

Chen

et al. 2024

Cell. Mol. Life Sci.

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Fibrosis is a typical aging-related pathological process involving almost all organs, including the heart, kidney, liver, lung, and skin. Fibrogenesis is a highly orchestrated process defined by sequences of cellular response and molecular signals mechanisms underlying the disease. In pathophysiologic conditions associated with organ fibrosis, a variety of injurious stimuli such as metabolic disorders, epigenetic changes, and aging may induce the progression of fibrosis. Sirtuins protein is a kind of deacetylase which can regulate cell metabolism and participate in a variety of cell physiological functions. In this review, we outline our current understanding of common principles of fibrogenic mechanisms and the functional role of SIRT3/6 in aging-related fibrosis. In addition, sequences of novel protective strategies have been identified directly or indirectly according to these mechanisms. Here, we highlight the role and biological function of SIRT3/6 focus on aging fibrosis, as well as their inhibitors and activators as novel preventative or therapeutic interventions for aging-related tissue fibrosis. Graphical abstract

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Section: Fibrosismentioning

confidence: 99%

SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging

Wei,

Li,

Chen

et al. 2024

Cell. Mol. Life Sci.

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“…Indeed, sirtuins activate the pAMPKα pathway, increase Bcl2 protein levels, inhibit NF-κB, decrease phosphoprotein kinase B protein, regulate energy metabolism through acetylation, suppress Wnt3a expression, and reduce Caspase3 mRNA and PARP1 protein levels. As a result, sirtuins exert protective effects against hypoxia-induced mitochondrial dysfunction, cytosolic release of cytochrome C, cardiac hypertrophy, and HF development [ 91 ].…”

Section: Mitochondrial Dysfunction and Cardiomyocyte Hypertrophymentioning

confidence: 99%

Mitochondrial Dysfunction in Heart Failure: From Pathophysiological Mechanisms to Therapeutic Opportunities

Gallo,

Rubattu,

Volpe

2024

IJMS

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Mitochondrial dysfunction, a feature of heart failure, leads to a progressive decline in bioenergetic reserve capacity, consisting in a shift of energy production from mitochondrial fatty acid oxidation to glycolytic pathways. This adaptive process of cardiomyocytes does not represent an effective strategy to increase the energy supply and to restore the energy homeostasis in heart failure, thus contributing to a vicious circle and to disease progression. The increased oxidative stress causes cardiomyocyte apoptosis, dysregulation of calcium homeostasis, damage of proteins and lipids, leakage of mitochondrial DNA, and inflammatory responses, finally stimulating different signaling pathways which lead to cardiac remodeling and failure. Furthermore, the parallel neurohormonal dysregulation with angiotensin II, endothelin-1, and sympatho-adrenergic overactivation, which occurs in heart failure, stimulates ventricular cardiomyocyte hypertrophy and aggravates the cellular damage. In this review, we will discuss the pathophysiological mechanisms related to mitochondrial dysfunction, which are mainly dependent on increased oxidative stress and perturbation of the dynamics of membrane potential and are associated with heart failure development and progression. We will also provide an overview of the potential implication of mitochondria as an attractive therapeutic target in the management and recovery process in heart failure.

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“…Sirtuins (SIRTs) are a class of highly conserved NAD + -dependent deacetylases which perform posttranslational modification (lysine residue acetylation) to regulate the function of proteins (Liu et al, 2023). They are present in various life forms ranging from bacteria to humans.…”

Section: Sirtuinsmentioning

confidence: 99%

Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases

Liu

Zhang

et al. 2023

Phytotherapy Research

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Cardiovascular diseases are currently the primary cause of mortality in the whole world. Growing evidence indicated that the disturbances in cardiac fatty acid metabolism are crucial contributors in the development of cardiovascular diseases. The abnormal cardiac fatty acid metabolism usually leads to energy deficit, oxidative stress, excessive apoptosis, and inflammation. Targeting fatty acid metabolism has been regarded as a novel approach to the treatment of cardiovascular diseases. However, there are currently no specific drugs that regulate fatty acid metabolism to treat cardiovascular diseases. Many traditional Chinese medicines have been widely used to treat cardiovascular diseases in clinics. And modern studies have shown that they exert a cardioprotective effect by regulating the expression of key proteins involved in fatty acid metabolism, such as peroxisome proliferator‐activated receptor α and carnitine palmitoyl transferase 1. Hence, we systematically reviewed the relationship between fatty acid metabolism disorders and four types of cardiovascular diseases including heart failure, coronary artery disease, cardiac hypertrophy, and diabetic cardiomyopathy. In addition, 18 extracts and eight monomer components from traditional Chinese medicines showed cardioprotective effects by restoring cardiac fatty acid metabolism. This work aims to provide a reference for the finding of novel cardioprotective agents targeting fatty acid metabolism.

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Cellular and molecular biology of sirtuins in cardiovascular disease

Cited by 10 publications

References 205 publications

SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging

SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging

Mitochondrial Dysfunction in Heart Failure: From Pathophysiological Mechanisms to Therapeutic Opportunities

Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases

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