Cellular and molecular mechanisms of kidney fibrosis

Djudjaj, Sonja; Boor, Peter

doi:10.1016/j.mam.2018.06.002

Cited by 344 publications

(271 citation statements)

References 454 publications

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“…Of interest, GO analysis showed the NCTD-regulated genes were enriched in categories related with focal adhesion, inflammatory response, regulation of cell proliferation, oxidation-reduction process, ECM, etc, which have been implicated to be associated with fibrosis. [24][25][26] The recent study reported by Arvaniti et al 27 using transcriptomics analysis of UUO mouse model and our results both confirmed in the enriched GO terms and KEGG pathways. Both of these two studies suggest critical roles of these pathways in the pathogenesis of renal fibrosis and also implies that NCTD exerts an anti-renal fibrotic effect possible through regulating these signaling.…”

Section: Discussionsupporting

confidence: 87%

RNA‐Seq analysis of potential lncRNAs and genes for the anti‐renal fibrotic effect of norcantharidin

Xiao

Liao

Tang

et al. 2019

J of Cellular Biochemistry

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Background As a common phenotype in chronic kidney disease, renal interstitial fibrosis has been largely studied. Norcantharidin (NCTD), a derivative of naturally occurring cantharidin, has an anti‐renal fibrotic effect. However, its underlying mechanisms of the protective role remain largely unknown. Long noncoding RNAs (lncRNAs) play vital parts in tissue homeostasis modulation under pathophysiological conditions. In this study, we discovered the underlying lncRNAs and genes, which may contribute to the anti‐renal fibrotic effects of NCTD. Methods RNA‐seq analysis was performed to evaluate profiling of lncRNAs and messenger RNAs (mRNAs) in kidney tissues of sham‐control, and unilateral ureteral obstruction (UUO) mouse models with or without NCTD treatment. Systematic bioinformatic analysis of expression levels was used in lncRNAs and mRNAs of NCTD‐treated UUO kidneys. Altered expression of lncRNAs and mRNAs levels was confirmed by quantitative real‐time polymerase chain reaction analysis. Results 467 lncRNAs and 1502 mRNAs were differentially expressed between UUO‐ and sham‐operated kidneys, and notably, these alterations in UUO‐operated kidney were partially reversed following NCTD treatment. Interestingly, the up‐regulation of lncRNA Gm16076, Gm26669, and down‐regulation of Fam120aos were highly correlated with the up‐regulation of mRNA levels of fibrosis‐related gene ITGB1, STAT3 and reduction of Pink1 in UUO kidney, respectively. Conclusions The result suggested lncRNAs‐regulated genes may contribute to the anti‐renal fibrotic effect under NCTD treatment, and thus targeting lncRNAs‐controlled genes and their related molecular signaling pathways may serve as a promising therapeutic target in renal fibrosis treatment.

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Section: Discussionsupporting

confidence: 87%

RNA‐Seq analysis of potential lncRNAs and genes for the anti‐renal fibrotic effect of norcantharidin

Xiao

Liao

Tang

et al. 2019

J of Cellular Biochemistry

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“…By hematoxylin and eosin stains, shenkang injection was found to alleviate these pathological and morphological changes in this study. And the most important fibrotic change is defined by formation and accumulation of extracellular matrix by kidney resident mesenchymal cells (Djudjaj et al, 2019). By sirius red stain, shenkang injection was found to decrease the deposition of collagen fibers, the basic components of extracellular matrix in this study.…”

Section: Discussionsupporting

confidence: 52%

Effects of shenkang injection on renal angiogenesis in mice with unilateral ureteral obstruction

Pan

Zhang

Liu

et al. 2020

Bangladesh J Pharmacol

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This study aimed to investigate effects of shenkang injection on angiogenesis in mice with renal fibrosis. C57BL/6J mice after unilateral ureteral obstruction were administrated with different doses of shenkang injection for two weeks. Losartan-administrated mice and Sham-operation mice were as positive and negative controls, respectively. Renal function and vasculature changes were observed, and expressions of VEGF and VEGFR2 were detected. Shenkang injection reduced serum levels of urea nitrogen, creatinine and cystatin C. Shenkang injection alleviated the loss of microvessels, decreased the deposition of collagen fibers, and increased expressions of VEGF and VEGFR2 in the obstructed kidney. These findings indicate that shenkang injection alleviates renal dysfunction and fibrotic changes in mice with renal fibrosis by regulating renal angiogenesis. Video Clip of Methodology: Renal Vasculature by Angiography: 6 min 41 sec: Full Screen Alternate

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“…Fibrosis is a process characterized by excessive deposits of extracellular matrix that leads to the replacement of functional parenchyma by fibrotic tissue [22]. Renal fibrosis is the common pathological process in chronic kidney disease, despite the underlying cause, in which kidney gradually lost its ability to repair as a result of ongoing tissue injury and inflammation [23]. However, renal fibrosis is a multifactorial and dynamic process that carries many cellular events in response to the injurious stimuli.…”

Section: Macrophage Phenotype and Fibrosismentioning

confidence: 99%

Macrophage Phenotype and Fibrosis in Diabetic Nephropathy

Calle

Hotter

2020

IJMS

149

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Diabetic nephropathy (DN) is the leading cause of end-stage renal disease globally. The primary initiating mechanism in DN is hyperglycemia-induced vascular dysfunction, but its progression is due to different pathological mechanisms, including oxidative stress, inflammatory cells infiltration, inflammation and fibrosis. Macrophages (Mφ) accumulation in kidneys correlates strongly with serum creatinine, interstitial myofibroblast accumulation and interstitial fibrosis scores. However, whether or not Mφ polarization is involved in the progression of DN has not been adequately defined. The prevalence of the different phenotypes during the course of DN, the existence of hybrid phenotypes and the plasticity of these cells depending of the environment have led to inconclusive results. In the same sense the role of the different macrophage phenotype in fibrosis associated or not to DN warrants additional investigation into Mφ polarization and its role in fibrosis. Due to the association between fibrosis and the progressive decline of renal function in DN, and the role of the different phenotypes of Mφ in fibrosis, in this review we examine the role of macrophage phenotype control in DN and highlight the potential factors contributing to phenotype change and injury or repair in DN.

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Cellular and molecular mechanisms of kidney fibrosis

Cited by 344 publications

References 454 publications

RNA‐Seq analysis of potential lncRNAs and genes for the anti‐renal fibrotic effect of norcantharidin

RNA‐Seq analysis of potential lncRNAs and genes for the anti‐renal fibrotic effect of norcantharidin

Effects of shenkang injection on renal angiogenesis in mice with unilateral ureteral obstruction

Macrophage Phenotype and Fibrosis in Diabetic Nephropathy

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