Cellular and Molecular Mechanisms of Immuno-modulation by Ganoderma lucidum

Lin, Zhibin

doi:10.1254/jphs.crj05008x

Cited by 166 publications

(124 citation statements)

References 24 publications

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…Now, the lentinan and polysaccharides of ganoderma lucidum, bidentata, polyporus, huangqi, yunzhi and etc are commonly used in clinical (Tzianabos, 2000;He et al, 2012). The immunologic enhancement of Chinese herbal medicine is realized via the following pathway: (1) activation of the reticuloendothelial and addiment system; (2) activation of macrophages, T and B lymphocytes, NK cells; (3) regulating the activity of immune promoters and inhibitors to enhance immunity of erythrocyte; (4) regulating the neuroendocrine network to play an immunomodulatory role; (5) induced various cytokines (CKs), including interferon (IFN-a, β, γ), interleukin (IL), tumor necrosis factor (TNF-a, β), colony-stimulating factor (CSF) and dozens of species from four series so far (Vincent et al, 2000;Lin, 2005;Xie et al, 2006;Jane et al, 2010;Jiang et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Polysaccharide Extracted from Rheum Tanguticum Prevents Irradiation-induced Immune Damage in Mice

Liu

Guo²,

Zhang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Aim: To investigate the protective effect of purified fraction 1 polysaccharide extracted from Rheum tanguticum RTP1 on irradiation-induced immune damage in mice. Methods: Kunming mice were randomly divided into five groups: normal group (NC), irradiation control group (IC), RTP1 low dose (200 mg/kg), middle dose (400 mg/kg) and high dose (800 mg/kg) groups. RTP1 was adminstered by the gastric route for 14 d, mice in the NC and IC groups being given by 0.9% sodium chloride solution in the same way. The mice in all groups except NC group were irradiated with 2.0 Gy 60 Co γ-ray on the fourteenth day. Immune indives of non-specific immune function, cellular immunity and humoral immunity were assessed at the 24th hour after radiation. Results: Compared with the IC group, the spleen index, thymus index, rate of carbon clearance, phagocytic function of macrophages, lymphocyte proliferation, hemolysin value of blood serum and NK activity were increased markedly (P < 0.05 or P < 0.05). Conclusion: RTP1 has an obvious protective effects on damage in γ-ray radiated mice.

show abstract

Section: Discussionmentioning

confidence: 99%

Polysaccharide Extracted from Rheum Tanguticum Prevents Irradiation-induced Immune Damage in Mice

Liu

Guo²,

Zhang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Two species, chi-zhi (赤芝) and zi-zhi ( G. sinense , 紫芝), are recorded as legal medicinal fungi in ‘Pharmacopoeia of People’s Republic of China 2000 edition (Part one)’ (CPC 2000). The principle therapeutical effect of Ling-zhi is to enhance the phagocytosis or cell cytotoxicity of immune cells, such as macrophages, natural killer cells, T lymphocytes, and B lymphocytes (Lin 2005). …”

Section: Ling-zhi Industry In Chinamentioning

confidence: 99%

Development of Ling-zhi industry in China – emanated from the artificial cultivation in the Institute of Microbiology, Chinese Academy of Sciences (IMCAS)

Dong

Wen

et al. 2016

Mycology

View full text Add to dashboard Cite

Ling-zhi is a medicinal herb that generally refers to a fungus in the genus Ganoderma. It has been used as a medicinal mushroom in traditional Chinese medicine for more than 2000 years. Mycologists at the Institute of Microbiology, Chinese Academy of Sciences (IMCAS) first artificially cultivated the Ling-zhi fruiting body in the late 1960s (X.J. Liu’s team). In IMCAS, different research teams have extensively studied Ling-zhi in the aspects of national resource surveys, systematic taxonomy, chemical analysis, and processing for medicinal and health applications. The research results from IMCAS have provided essential support and prompted the development of the Ling-zhi industry in China to some extent. This review aims to summarize the history of research on Ling-zhi in IMCAS and its role in the development of the Ling-zhi economy.

show abstract

“…Clinical trials have provided some evidence that they can improve survival 105 . The polysaccharide complexes and extracts include constituents of Coriolus versicolor (whose extract is called Krestin, PSK, or PSP) 106-118 , Ganoderma lucidum [119][120][121] , Grifola frondosa (maitake MD-fraction) 122-127 , Astragalus membranaceus 128 , Panax ginseng [129][130][131][132] , and various other medicinal mushrooms [133][134][135] .…”

Section: Herbsmentioning

confidence: 99%

“…Data from controlled clinical trials suggest that medicinal mushrooms may be beneficial as adjunctive anticancer therapies 120,186 . A RCT in colorectal cancer patients receiving curative resection compared adjuvant chemotherapy alone to chemotherapy plus an extract (PSK) from the fungus Coriolus versicolor.…”

Section: Prevention Of Cancer Progressionmentioning

confidence: 99%

Chinese Medicine and Biomodulation in Cancer Patients—Part Two

Sagar

Wong

2008

Current Oncology

View full text Add to dashboard Cite

Traditional Chinese Medicine (TCM) is a whole system containing therapeutic interventions that individually induce biomodulation at the physiologic, chemical, and molecular levels. The theory of TCM proposes a synergy between specific interventions selected as part of a care plan based on TCM diagnostic theory. Combining TCM with the modern practice of oncology seems, in conjunction with biomedical interventions (surgery, radiotherapy, chemotherapy, and pharmaceuticals), to have potential advantages through the synergy of biomodulation. Biomodulation approaches are broadly categorized as modification of tumour response and reduction of adverse effects; modulation of immunity; prevention of cancer progression; and enhancement of symptom control. Although the database of preclinical studies is rapidly expanding, good-quality clinical trials are notably scarce.Laboratory studies suggest that some herbs increase the effectiveness of conventional chemotherapy without increasing toxicity. A healthy immune system is necessary for control of malignant disease, and the immune suppression associated with cancer contributes to its progression. Many Chinese herbs contain glycoproteins and polysaccharides (among them, constituents of Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, Astragalus membranaceus, Panax ginseng, and various other medicinal mushrooms) that can modulate metastatic potential and the innate immune system. Phytochemicals such as specific polysaccharides have been shown to boost the innate immune system, especially through interaction with Tolllike receptors in mucosa-associated lymphoid tissue. This intervention can potentially improve the effectiveness of new anticancer vaccines. An increase in virusassociated cancers presents a major public health problem that requires novel therapeutic strategies. A number of herbal therapies have both antiviral activity and the ability to promote immunity, possibly inhibiting the initiation and promotion of virus-associated cancers.The mechanisms learned from basic science should be applied to clinical trials both of specific interventions and of whole-system care plans that safely combine the TCM approach with the conventional biomedical model. In Western medicine, the combination of TCM herbs with drug therapies is controversial, given lack of knowledge concerning whether a drug is favourably enhanced or whether adverse effects occur. Using initial data from the preclinical studies, future clinical research needs to evaluate the combinations, some of which are showing favourable synergy.

show abstract

Cellular and Molecular Mechanisms of Immuno-modulation by Ganoderma lucidum

Cited by 166 publications

References 24 publications

Polysaccharide Extracted from Rheum Tanguticum Prevents Irradiation-induced Immune Damage in Mice

Polysaccharide Extracted from Rheum Tanguticum Prevents Irradiation-induced Immune Damage in Mice

Development of Ling-zhi industry in China – emanated from the artificial cultivation in the Institute of Microbiology, Chinese Academy of Sciences (IMCAS)

Chinese Medicine and Biomodulation in Cancer Patients—Part Two

Contact Info

Product

Resources

About