Cellular and molecular mechanisms of DEET toxicity and disease-carrying insect vectors: a review

Shrestha, Bhanu; Lee, Youngseok

doi:10.1007/s13258-020-00991-z

Cited by 14 publications

(13 citation statements)

References 108 publications

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“…Therefore, other alternatives to DEET, such as coconut oil, picaridin, lemon eucalyptus oil, permethrin, etc. are being explored by researchers to develop new repellent compounds with higher efficacy and pleasant smells [23,239]. In this quest, saponins have emerged as compounds that can be used as a substitute for DEET.…”

Section: Gustation-based Repugnancy-how Repellents Target the Gustato...mentioning

confidence: 99%

“…Insects are one of the major sources of the transmission of pathogens to humans and cattle, as well as the destruction of food crops [22]. Mosquitoes, ticks, sandflies, and mites are a few of the major insect vectors that spread life-threatening diseases to human beings, such as; malaria, dengue, West Nile fever, encephalitis, yellow fever, and Congo hemorrhagic disease [23]. In particular, mosquitoes are the biggest menace to the human population.…”

Section: Introductionmentioning

confidence: 99%

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Drosophila melanogaster Chemosensory Pathways as Potential Targets to Curb the Insect Menace

Ali

Anushree

Bilgrami

et al. 2022

Insects

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From a unicellular bacterium to a more complex human, smell and taste form an integral part of the basic sensory system. In fruit flies Drosophila melanogaster, the behavioral responses to odorants and tastants are simple, though quite sensitive, and robust. They explain the organization and elementary functioning of the chemosensory system. Molecular and functional analyses of the receptors and other critical molecules involved in olfaction and gustation are not yet completely understood. Hence, a better understanding of chemosensory cue-dependent fruit flies, playing a major role in deciphering the host-seeking behavior of pathogen transmitting insect vectors (mosquitoes, sandflies, ticks) and crop pests (Drosophila suzukii, Queensland fruit fly), is needed. Using D. melanogaster as a model organism, the knowledge gained may be implemented to design new means of controlling insects as well as in analyzing current batches of insect and pest repellents. In this review, the complete mechanisms of olfactory and gustatory perception, along with their implementation in controlling the global threat of disease-transmitting insect vectors and crop-damaging pests, are explained in fruit flies.

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Section: Gustation-based Repugnancy-how Repellents Target the Gustato...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Drosophila melanogaster Chemosensory Pathways as Potential Targets to Curb the Insect Menace

Ali

Anushree

Bilgrami

et al. 2022

Insects

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“…Despite numerous efforts to control mosquito populations, the use of mosquito repellents remains an affordable approach for personal protection from mosquito bites , However, several studies have brought to light its potential adverse effects on human health − and clear hints of mosquito resistance. − Bio-sourced mosquito repellents are hence emerging for a safer use and for a better respect of the environment-friendly criterions defined by consumers’ expectations. Although half as active as DEET, p -menthane-3,8-diol (PMD) is the most active natural repellent .…”

Section: Introductionmentioning

confidence: 99%

Efficient and Greener Process for the Production of p-Menthane-3,8-diols Using Biosourced Ammonium Salts as Catalysts

Stanovych

Pélissier

Grison

et al. 2023

ACS Sustainable Chem. Eng.

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p-Menthane-3,8-diol (PMD) is gradually dethroning the synthetic golden standard mosquito repellent, N,N-diethyl-m-toluamide (DEET), as PMD is natural and considered safer while displaying an excellent repellent activity. In this study, we revisited the synthetic route of PMD from citronellal in greener conditions, while maintaining the highest yield, and developed a sustainable post-reaction process. Biosourced ammonium salts were tested to catalyze the carbonyl-ene reaction-hydration transforming citronellal and essential oils rich in citronellal into PMD. Ammonium salts led to excellent conversions and selectivities toward PMD, better than previously reported, even at low catalytic loading and rapidly. Catalytic solution of ammonium salts could be directly reused, up to six times without any loss of activity. The sustainability of the methodology was evaluated using a holistic approach which gave excellent green metrics, such as the PMI (6), TON (708), TOF (17), and E-factor (0.68) in comparison to other processes. The repellent activities of PMD synthesized from citronellal and from essential oils were evaluated against Aedes albopictus, the most invasive mosquito in the world, and were as much or even more repellent than pure PMD.

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“…Fourth, stimulation of gustatory receptor neurons (GRNs) occurs by tasting DEET by labellum which leads to the activation of bitter GRNs. Fifth, Inhibition of sweet GRNs occurs on tasting DEET with labellum [ 3 , 4 , 5 ]. The DEET is incorporated into topical formulation from 7–10% (short periods, approximately 2 h) to 20–30% (longer periods, approximately 6 h) [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

N,N-Diethyl-3-toluamide Formulation Based on Ethanol Containing 0.1% 2-Hydroxypropyl-β-cyclodextrin Attenuates the Drug’s Skin Penetration and Prolongs the Repellent Effect without Stickiness

Nagai

Kawaguchi²,

Minami³

et al. 2022

Molecules

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N,N-diethyl-3-toluamide (DEET) is one of the most widely used insect repellents in the world. It was reported that a solution containing 6–30% cyclodextrin (CD) as a solvent instead of ethanol (EtOH) provided an enhancement of the repellent action time duration of the DEET formulation, although the high-dose CD caused stickiness. In order to overcome this shortcoming, we attempted to prepare a 10% DEET formulation using EtOH containing low-dose CDs (β-CD, 2-hydroxypropyl-β-CD (HPβCD), methyl-β-CD, and sulfobutylether-β-CD) as solvents (DEET/EtOH/CD formulations). We determined the CD concentration to be 0.1% in the DEET/EtOH/CD formulations, since the stickiness of 0.1% CDs was not felt (approximately 8 × 10−3 N). The DEET residue on the skin superficial layers was prolonged, and the drug penetration into the skin tissue was decreased by the addition of 0.1% CD. In particular, the retention time and attenuated penetration of DEET on the rat skin treated with the DEET/EtOH/HPβCD formulation was significantly higher in comparison with that of the DEET/EtOH formulation without CD. Moreover, the repellent effect of DEET was more sustained by the addition of 0.1% HPβCD in the study using Aedes albopictus. In conclusion, we found that the DEET/EtOH/HPβCD formulations reduced the skin penetration of DEET and prolonged the repellent action without stickiness.

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Cellular and molecular mechanisms of DEET toxicity and disease-carrying insect vectors: a review

Cited by 14 publications

References 108 publications

Drosophila melanogaster Chemosensory Pathways as Potential Targets to Curb the Insect Menace

Drosophila melanogaster Chemosensory Pathways as Potential Targets to Curb the Insect Menace

Efficient and Greener Process for the Production of p-Menthane-3,8-diols Using Biosourced Ammonium Salts as Catalysts

N,N-Diethyl-3-toluamide Formulation Based on Ethanol Containing 0.1% 2-Hydroxypropyl-β-cyclodextrin Attenuates the Drug’s Skin Penetration and Prolongs the Repellent Effect without Stickiness

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