Cellular blue nevus:Clinicopathologic study of forty-five cases

Oral Atypical Cellular Blue Nevus: An Infiltrative Melanocytic Proliferation

“…Evaluation of their ACBN case series (N = 9) alone yielded an average age of 47.4 years; similar to our case. The CBN occur on the buttocks/lumbosacral region followed by the scalp, face and hand [2,23]. ACBN cases similarly affect the buttocks, scalp and the extremities [16,17,27] while MBN have somewhat greater propensity to affect the scalp [11].…”

“…The cellular blue nevus (CBN) is a well-characterized benign, acquired dermal melanocytic tumor [1,2]. While clinically indistinguishable from the common blue nevus [3], it is microscopically distinguished by a biphasic proliferation of hypercellular, nodular aggregates of tumor cells which often lie deep to a typical blue nevus.…”

“…The border shows well-demarcated tumor nodules with rare infiltration and a notably absent host inflammatory response. The cellular portion contains ovoid to spindleshaped melanocytes with small nucleoli and variable pigmentation [2,3]. Mitotic activity can be seen (B2 mitoses/ mm 2 ) while necrosis as well as junctional activity or epidermal invasion are typically absent [2,4].…”

“…The cellular portion contains ovoid to spindleshaped melanocytes with small nucleoli and variable pigmentation [2,3]. Mitotic activity can be seen (B2 mitoses/ mm 2 ) while necrosis as well as junctional activity or epidermal invasion are typically absent [2,4]. Following conservative excision, long-term follow-up data indicate a very small risk for recurrence and no metastasis [2].…”

“…Mitotic activity can be seen (B2 mitoses/ mm 2 ) while necrosis as well as junctional activity or epidermal invasion are typically absent [2,4]. Following conservative excision, long-term follow-up data indicate a very small risk for recurrence and no metastasis [2]. In the oral cavity, common blue nevi are occasionally seen [5], while cellular blue nevi are exceedingly rare, with only 2 reported cases [6,7].…”