Cellular calcium signaling in the aging brain

Remya, Chandran; Kumar, Manish; Kesavan, Lakshmi; Jacob, Reena Sarah; Gunasekaran, Sowmya; Lakshmi, S. Muthu; Sadasivan, C.; Omkumar, Ramakrishnapillai V.

doi:10.1016/j.jchemneu.2017.11.008

Cited by 49 publications

(41 citation statements)

References 385 publications

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“…Dysregulated Ca 2+ levels contribute to aging because continued increases in Ca 2+ promote oxidative damage, metabolic stress, mitochondrial dysfunction, and apoptosis. In neurons, physiological levels of Ca 2+ are essential for modulating synaptic transmission, synaptic plasticity, and survival, but an uncontrolled increase of Ca 2+ activates phospholipases, endonucleases, and Ca 2+ ‐sensitive proteases such as calpains, promotes caspase‐mediated apoptosis, stimulates PARP1‐mediated cell death, and decreases expression of BDNF, which leads to age‐related neurodegeneration …”

Section: Molecular Mechanisms Of Agingmentioning

confidence: 99%

Advantages and disadvantages of apoptosis in the aging process

Argüelles

Guerrero‐Castilla

Cano

et al. 2019

Annals of the New York Academy of Sciences

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Researchers cannot predict as yet how long a human being can live. Life expectancy has been steadily increasing in the last century, but perhaps not always the quality of life in parallel with it. Future generations will be faced with the problems of an increased life expectancy along with the emergence of new age-related diseases. A deeper understanding of the aging process is crucial to ameliorate, if not to prevent, these projected new old-age diseases. One of the mechanisms responsible for healthy aging is through the effective maintenance of physiological, biochemical, and immunological functions. To carry this out, the organism needs to create new cells to replace old ones and to induce the disappearance of old and damaged cells. Apoptosis is involved in all these processes. However, if apoptosis is dysregulated, premature senescence-associated diseases are likely to appear. In our review, the focus will be on a better understanding of the role of apoptosis in the aging process. These signaling pathways will most assuredly be pharmacologically targeted in antiaging medicine therapies.

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Section: Molecular Mechanisms Of Agingmentioning

confidence: 99%

Advantages and disadvantages of apoptosis in the aging process

Argüelles

Guerrero‐Castilla

Cano

et al. 2019

Annals of the New York Academy of Sciences

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“…Changes in calcium signaling are major factors leading to aging, as many vital functions of the brain depend on precise calcium homeostasis [132]. Khachaturian presented in 1994 his hypothesis of aging [133] to try to elucidate the neurophysiological mechanisms of Ca 2+ signaling that they are associated with aging and neurodegeneration.…”

Section: Hiv-1 Disrupts the Calcium Signaling In The Brainmentioning

confidence: 99%

Brain Aging in HIV-1 Infection

Santerre¹,

Sawaya²

2018

Advances in HIV and AIDS Control

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It has been shown that patients carrying HIV-1 accumulate damage to cells and tissues that are not directly infected by the virus itself (e.g., neurons). Importantly, these include changes known as HIV-Associated Neurodegenerative Disorder (HAND) leading to the loss of neuronal functions. HAND is an outstanding problem in the clinical management of HIV-1 patients because suppression of infectious virus by cART does not completely block neurodegenerative changes. Neuropsychological studies disclose cognitive alteration (such as loss of Spatial and Declarative Memory) in a substantial proportion of HIV-1 infected patients, and analysis of post-mortem brain tissues isolated from HIV-1 patients treated with cART show signs of neurodegeneration. In the absence of HIV-1 infection of neurons, several mechanisms have been proposed for HAND, including indirect inflammatory effects in the CNS and direct effects of viral proteins (e.g., gp120) shed from activated HIV-1-infected cells. The fact that these viral proteins enter the neurons through several pathways suggests the presence of many competing mechanisms that can contribute to HAND, each of which has its advocates. Their relative contributions to clinical disease in vivo remain to be sorted out, and this is an outstanding problem in HIV research. This chapter will shed some light on the mechanisms used by HIV-1 leading to memory impairments and premature brain aging.

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“…Interestingly, several of the above-mentioned processes regulated by Ca 2+ are directly or indirectly important for correct brain function. An important role for intracellular Ca 2+ in aging and neurodegenerative diseases is therefore emerging (see, e.g., recent reviews [8][9][10][11][12][13]), but a deeper understanding of the exact role of Ca 2+ signaling in the physiological aging process, and in the occurrence and progression of various age-related pathologies is now urgently needed.…”

mentioning

confidence: 99%