Cellular changes in boric acid-treated DU-145 prostate cancer cells

Barranco, Wade T.; Eckhert, Curtis D.

doi:10.1038/sj.bjc.6603009

Cited by 98 publications

(109 citation statements)

References 34 publications

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“…16,[32][33][34] Recent epidemiological, in vitro, and animal studies reveal a possible role for boric acid (BA), the most abundant physiological form of boron in the plasma, as a chemotherapeutic agent. [16][17][18][19][20][21] In a nude mouse model of prostate cancer, BA decreases tumor size, IGF-1 serum levels and PSA levels and proteolytic activity. 20,21 Barranco et al also demonstrate that 1 mM of boric acid significantly decreases migration and proliferation of the prostate cancer cell line DU-145 in vitro.…”

Section: Introductionmentioning

confidence: 99%

“…20,21 Barranco et al also demonstrate that 1 mM of boric acid significantly decreases migration and proliferation of the prostate cancer cell line DU-145 in vitro. 17,18 These studies motivate our search for additional derivatives of BA that may be effective at selectively inhibiting the metastatic properties of tumor cells. In addition, we are also interested in expanding the possible targets of these compounds to other cancer types.…”

Section: Introductionmentioning

confidence: 99%

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Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability

Bradke

Hall

Carper

et al. 2008

Cell Adhesion & Migration

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We compared the in vitro effect of boric acid (BA) versus phenylboronic acid (PBA) on the migration of prostate and breast cancer cell lines and non-tumorigenic cells from the same tissues. Treatment at 24 hours with BA (≤500 μM) did not inhibit chemotaxis on fibronectin in any cell line. However, treatment over the same time course with concentrations of PBA as low as 1 μM significantly inhibited cancer cell migration without effecting nontumorigenic cell lines. The compounds did not affect cell adhesion or viability at 24 hours but did alter morphology; both decreased cancer cell viability at eight days. These results suggest that PBA is more potent than BA in targeting the metastatic and proliferative properties of cancer cells.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability

Bradke

Hall

Carper

et al. 2008

Cell Adhesion & Migration

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“…There is also evidence that B plays a role in healthy bones and joints 12,13 . Additionally, in recent years there have also been some promising results concerning the treatment of certain malignancies 14,15 .Toxicological effects have also been reported in animals at higher doses, e.g in mice, rats and rabbits skeletal malformations and cardiovascular defects have been observed 16,17 . Although not confirmed, it was claimed that B had a deleterious effect in humans, the target organ being the testis.…”

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confidence: 99%

Estimation of human daily boron exposure in a boron-rich area

Korkmaz

Şaylı²,

Sayli

et al. 2007

Br J Nutr

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Although, the safe limits of human daily boron (B) exposure are not absolutely clear, there is a growing interest in B and its effects on human health. The aim of the present study was to estimate daily B exposure in 66 males in Turkey living in a B-rich area using water containing at least 2 mg/l boron, with an average age of 38·55 (SE 1·66) years and an average number of years of residence in the B-rich area of 35·89 (SE 1·73). Another group of males (n 57), living in the city centres of Balıkesir and Ankara, were taken as controls; the average age and number of years of residence for this group were 29·44 (SE 1·43) and 10·26 (SE 1·83) years, respectively. As it is assumed that the B level in urine reflects daily B exposure, the amount of urinary B of both the study and control groups was analysed by using an inductively coupled plasma optical emission spectrometry (ICP-OES) technique. The average daily B exposure value was calculated as 6·77 (SE 0·47) mg in the study group and 1·26 (SE 0·1) mg in the controls. The results of this study are expected to contribute to creating a reference value for a safe daily B exposure. Boron: Daily exposure: Risk assessmentRecent studies conducted both in vitro and epidemiologically have indicated that boron (B) exposure may make significant contributions to human health 1 -3 . Humans are naturally exposed to B via food and drinking water 4 . B is absorbed almost completely by the gastrointestinal and respiratory system if exposure occurs, and is mostly present in body tissues and fluids as boric acid, B(OH) 3 , and in lesser amounts as B(OH) 4 2 anion 5 . Studies indicate that B homeostasis is basically maintained by urinary excretion 6 .B was defined as a trace element in 1980 7 . In spite of the lack of epidemiological data, the WHO reported that boron may provide a physiological benefit for human health 8 . Safe and/or beneficial B levels have not been determined for humans, though animal studies have defined deleterious and beneficial B levels for animals 9 .In a study by Penland 10 , it was outlined that B improves brain function and psychomotor response. It increases steroid hormone concentrations and has antioxidant properties in postmenopausal women 9,11 . There is also evidence that B plays a role in healthy bones and joints 12,13 . Additionally, in recent years there have also been some promising results concerning the treatment of certain malignancies 14,15 .Toxicological effects have also been reported in animals at higher doses, e.g in mice, rats and rabbits skeletal malformations and cardiovascular defects have been observed 16,17 . Although not confirmed, it was claimed that B had a deleterious effect in humans, the target organ being the testis. Atrophy and eventual degeneration of the organ in several animal species at high doses have been shown 18,19 . Initially, reproduction toxicology studies were based upon data obtained from animal studies and adapted to human risk evaluations 20 . It was reported in several field studies that B does not affect human r...

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“…As defined previously, 98.4% of the boron in the blood is found in the form of boric acid [28]. According to several studies, the supplementation of food with boron reduces the risk of some cancers [29,30]. Moreover, Gallardo-Williams et al showed that additional boron taken with food reduces the size of tumors and the level of IGF-I in rats [31].…”

Section: Discussionmentioning

confidence: 88%