Cellular density, a major factor involved in PDT cytotoxic responses: Study on three different lines of human retinoblastoma grafted on nude mice

Topical Application of the Anthraquinone Parietin and Blue Light Illumination Induces Delayed Cell Growth and Necrosis in the Deeper Layers of a Subcutaneously Implanted Tumour

“…Although blue light penetration into normal skin has been reported to be around 1 mm [40], it had been used successfully in the treatment of skin cancers such as human basal cell carcinomas [41] and melanoma mice lesions of 100-120 mm 3 [42]. In addition, a bystander effect that may propagate the cellular death triggered by the initial photoreaction may be also occurring [43].…”

The Effect of Indocyanine Green Antimicrobial Photothermal/Photodynamic Therapy on the Expression of BCL-2 and BAX Messenger RNA Levels in Human Gingival Fibroblast Cells

“…37 PS concentration also plays an important role in cell cytotoxicity. 38 To further investigate the potential asso-um) cells to 0.01 mg/mL of ICG for 3 h, 1 mg/mL of ICG for 20 min, and 5 mg/mL of ICG for 10 min without cytotoxicity. As in the Ho et al 42 study, Peters et al 43 stated that ICG did not exhibit cytotoxicity for ARPE-19 cells with an ICG concentration at or below 1250 μg/mL; however, with higher ICG concentrations, a toxic effect was observed.…”

Looking for the Most Suitable Orthotopic Retinoblastoma Mouse Model in Order to Characterize the Tumoral Development

“…Four retinoblastoma lines (Rb-102, Rb-109, Rb-111, and Rb-200) were used in previous studies to evaluate photodynamic therapy responses on subcutaneous xenografts. 6,8,10 Due to the rapid growth (obtained in~6 weeks) of the Rb-200 tumor line on subcutaneous models, we used only this retinoblastoma PDX to establish the orthotopic model in this study.…”