Cellular discharge in the dorsolateral prefrontal cortex of the monkey in cognitive tasks

Fuster, Joaquı́n M.; Bauer, Richard H.; Jervey, John P.

doi:10.1016/0014-4886(82)90238-2

Cited by 338 publications

(146 citation statements)

References 23 publications

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“…Finally, we also found evidence of sensory-related activity that reflected the samples seen at the start of the trial. This has been found in previous studies (Fuster et al, 1982;Funahashi et al, 1989;di Pellegrino and Wise, 1991;Wilson et al, 1993;Miller et al, 1996;Rao et al, 1997;Asaad et al, 1998;Rainer et al, 1998a,b).…”

Section: Discussionsupporting

confidence: 87%

“…Area 46 also receives inputs from the posterior parietal cortex (Goldman-Rakic and Schwartz, 1982), a region that also contains object-selective neurons (Sereno and Maunsell, 1998). Previous studies have shown that these prefrontal regions contain object-selective neurons (Watanabe, 1981;Fuster et al, 1982;Wilson et al, 1993;Rao et al, 1997;Asaad et al, 1998;Rainer et al, 1998a,b;O Scalaidhe et al, 1998).…”

Section: Neural Data: General Propertiesmentioning

confidence: 98%

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Prospective Coding for Objects in Primate Prefrontal Cortex

1999

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We examined neural activity in prefrontal (PF) cortex of monkeys performing a delayed paired associate task. Monkeys were cued with a sample object. Then, after a delay, a test object was presented. If the test object was the object associated with the sample during training (i.e., its target), they had to release a lever. Monkeys could bridge the delay by remembering the sample (a sensory-related code) and/or thinking ahead to the expected target (a prospective code). Examination of the monkeys' behavior suggested that they were relying on a prospective code. During and shortly after sample presentation, neural activity in the lateral PF cortex primarily reflected the sample. Toward the end of the delay, however, PF activity began to reflect the anticipated target, which indicated a prospective code. These results provide further confirmation that PF cortex does not simply buffer incoming visual inputs, but instead selectively processes information relevant to current behavioral demands, even when this information must be recalled from long-term memory.

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Section: Discussionsupporting

confidence: 87%

Section: Neural Data: General Propertiesmentioning

confidence: 98%

Prospective Coding for Objects in Primate Prefrontal Cortex

1999

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“…First, Rao, Rainer, and Miller (1997) have shown that one can record both spatial location and visual object information from the same cell within the dorsolateral prefrontal cortex and these cells can change very readily based on the demands of the task. Second, Fuster, Bauer, and Jervey (1982) showed that delay cells can be found in both the dorsolateral and ventrolateral prefrontal cortex in a visual-visual stimulus or spatial location-spatial location matching-to-sample tasks. In humans, D'Esposito et al (1998) reported a meta-analysis of neuroimaging results based on visual object and spatial location working memory tasks which provided a strong case for processing of both visual object and spatial location information in working memory in both the dorsolateral and ventrolateral prefrontal cortex.…”

Section: Working Memory (Short-term Memory)mentioning

confidence: 99%

Neurobiological foundations of an attribute model of memory

Kesner¹

2013

CCBR

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Memory is a complex phenomenon due to a large number of potential interactions that are associated with the organization of memory at the psychological and neural system level. In this review article a tripartite, multiple attribute, multiple process memory model with different forms of memory and its neurobiological underpinnings is represented in terms of the nature, structure or content of information representation as a set of different attributes including language, time, place, response, reward value (affect) and visual object as an example of sensory-perception. For each attribute, information is processed in the event-based, knowledge-based, and rule-based memory systems through multiple operations that involve multiple neural underpinnings. Of the many processes associated with the event-based memory system, the emphasis will be placed on short-term or working memory and pattern separation. Of the many processes associated with the knowledgebased memory system, the emphasis will be placed on perceptual processes. Of the many processes associated with the rule-based memory system the emphasis will be on short-term or working memory and paired associate learning. For all three systems data will be presented to demonstrate differential neuroanatomical mediation and where available parallel results will be presented in rodents, monkeys and humans.

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“…Furthermore, deep layer III cells are involved in cortico-cortico and cortico-thalamic circuitry and evidence suggests disruptions in the functional integrity of both circuits in SCZ (Bunney and Bunney, 2000;Tekin and Cummings, 2002). Alterations in GRIA1 subunit mRNA expression in Layer III pyramidal cell populations may disrupt the intrinsic and projection circuitry of the DLPFC which regulates critical elements of working memory (Fuster et al, 1982;GoldmanRakic, 1990;Goldman-Rakic, 1995;Kubota and Niki, 1971).…”

Section: Discussionmentioning

confidence: 99%

Elevated GRIA1 mRNA expression in Layer II/III and V pyramidal cells of the DLPFC in schizophrenia

O’Connor

Hemby

2007

Schizophrenia Research

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The functional integrity of the dorsolateral prefrontal cortex (DLPFC) is altered in schizophrenia leading to profound deficits in working memory and cognition. Growing evidence indicates that dysregulation of glutamate signaling may be a significant contributor to the pathophysiology mediating these effects; however, the contribution of NMDA and AMPA receptors in the mediation of this deficit remains unclear. The equivocality of data regarding ionotropic glutamate receptor alterations of subunit expression in the DLPFC of schizophrenics is likely reflective of subtle alterations in the cellular and molecular composition of specific neuronal populations within the region. Given previous evidence of Layer II/III and V pyramidal cell alterations in schizophrenia and the significant influence of subunit composition on NMDA and AMPA receptor function, laser capture microdissection combined with quantitative PCR was used to examine the expression of AMPA (GRIA1-4) and NMDA (GRIN1, 2A and 2B) subunit mRNA levels in Layer II/III and Layer V pyramidal cells in the DLPFC. Comparisons were made between individuals diagnosed with schizophrenia, bipolar disorder, major depressive disorder and controls (n=15/ group). All subunits were expressed at detectable levels in both cell populations for all diseases as well as for the control group. Interestingly, GRIA1 mRNA was significantly increased in both cell types in the schizophrenia group compare to controls, while similar trends were observed in major depressive disorder (Layers II/III and V) and bipolar disorder (Layer V). These data suggest that increased GRIA1 subunit expression may contribute to schizophrenia pathology.

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Cellular discharge in the dorsolateral prefrontal cortex of the monkey in cognitive tasks

Cited by 338 publications

References 23 publications

Prospective Coding for Objects in Primate Prefrontal Cortex

Prospective Coding for Objects in Primate Prefrontal Cortex

Neurobiological foundations of an attribute model of memory

Elevated GRIA1 mRNA expression in Layer II/III and V pyramidal cells of the DLPFC in schizophrenia

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