Cellular Inflammatory Indices in Hospitalized Nigerian COVID-19 Patients

Akinwumi, Jeremiah A.; Edem, Fabian; Arinola, Ganiyu Olatunbosun

doi:10.7324/jhsr.2021.623

Cited by 7 publications

(12 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As recently documented by Kuluöztürk, the Glasgow prognostic score also has been observed to correlate with COVID-19 infection severity and worse outcome among Turkish patients [22]. The current data presented in this study corroborates the widely observed pathophysiologic basis of COVID-19 severity and underscore the role played by hyper-inflammation in the disease evolution and progression [11][12][13][14][15][16][17][18][19][20][21][22].…”

Section: Relationship With Existing Literaturesupporting

confidence: 86%

“…In another study reported by Iqbal and colleagues among Indian COVID-19 patients with a relatively large sample size population (n=433) compared to that of Alam and colleagues, the authors found elevated pro-inflammatory markers including CRP among the severely ill patients and they concluded that the pro-inflammatory markers be used to differentiate severe from non-severe patients with COVID-19 infection [7]. Similar findings have been documented in two previous Nigerian studies [12,16].…”

Section: Relationship With Existing Literaturesupporting

confidence: 66%

“…A large number of studies reported since the COVID-19 outbreak have previously shown the release of several markers/indices, pro-inflammatory in characteristics, such as CRP, D-Dimer, Glasgow prognostic scores, and the neutrophil to lymphocyte parameters due to altered physiological and biochemical processes initiated by the disease, resulting in the severity of the disease and resultant adverse consequences such as heightened morbidity/mortality [16][17][18][19].…”

Section: Relationship With Existing Literaturementioning

confidence: 99%

See 2 more Smart Citations

Potentials of Varied Inflammatory Indices in the Prediction of COVID-19 Severity Among Nigerians

Lawson¹,

Amadi²

2022

View full text Add to dashboard Cite

Background: The coronavirus disease of 2019 ) is theorized to be associated with significant inflammatory episodes. This tends to define the severity and culminates in adverse consequences of the disease. Therefore, the current study evaluated the potentials of varied inflammatory markers/indices that define the COVID-19 severity. Methods: This was a retrospective analysis of pre-treatment data obtained from patients with positive real-time polymerase chain reaction (RT-PCR)-confirmed COVID-19 disease in one of the treatment centers in Port Harcourt, South-south Nigeria. Data were obtained from case notes, medical review charts, nurses' charts, and laboratory records by trained research assistants in the treatment center using pretested data acquisition templates. Abstracted data were compared between the severe positive and severe negative subgroups and the potentials of varied inflammatory indices were evaluated among the severe positive subgroup using standard protocols. Results: A total of 600 eligible cases were studied. Among the eligible cases, 543 (90.5%) had severe negative disease, while 57 (9.5%) had severe positive disease. The severe positive COVID-19 patients had higher mean blood levels of urea, creatinine, pro-calcitonin, C-reactive protein (CRP), ferritin, higher Glasgow prognostic scores (GPS), fibrinogen, D-dimer, fibrinogen-albumin ratio, total white cell count, neutrophil counts, composite neutrophil/lymphocyte ratio (NLR), composite platelet to lymphocyte ratio but lower potassium, albumin, hemoglobin levels, and isolated lymphocyte and platelet counts compared to the severe positive COVID-19 subjects (p<0.05). The C-reactive protein, GPS, D-dimer, and the composite NLR ratio indices significantly predicted COVID-19 severity on the crude regression model which was maintained in the adjusted model. However, serum CRP concentrations (AUC: 0.95; 95% CI: 0.82-1.00; p<0.001) maintained a more robust predictive potential compared to the GPS (AUC: 0.94; 95% CI: 0.84-1.00; p<0.001), D-dimer levels (AUC: 0.89; 95% CI: 0.79-0.94; p=0.004), and the composite NLR (AUC: 0.87; 95% CI: 0.77-0.92). Conclusion:The current study corroborates the role of inflammation in the COVID-19 disease severity. The clinical utility of these inflammation-induced markers/indices especially the CRP, GPS, D-dimer, and the NLR should be prioritized among Nigerians during the management of the disease.

show abstract

Section: Relationship With Existing Literaturesupporting

confidence: 86%

Section: Relationship With Existing Literaturesupporting

confidence: 66%

Section: Relationship With Existing Literaturementioning

confidence: 99%

See 1 more Smart Citation

Potentials of Varied Inflammatory Indices in the Prediction of COVID-19 Severity Among Nigerians

Lawson¹,

Amadi²

2022

View full text Add to dashboard Cite

show abstract

“…3,10 Leukopenia, leukocytosis, neutropenia and lymphopenia are among the most common laboratory abnormalities in COVID-19. 13,14 Tan et al showed that lymphocyte percentage was inversely related to the severity and prognosis of COVID-19 patients. 13 Although, reports on haemocytometric changes in COVID-19 infection at different stages of the disease are many, the roles of these changes in indicating disease prognostication is still poorly understood especially, in Nigerian COVID-19 patients.…”

Section: Introductionmentioning

confidence: 99%

“…Moreso, repurposed medication used for COVID-19 patients at IDC, Ibadan, Nigeria are combinations of vitamin D, vitamin C, Zn, azithromycin, hydroxychloroquine and chloroquine (as an alternative to hydroxychloroquine). 14,[16][17][18][19][20] The treatment options for COVID-19 at this center are largely supportive as there is no universally agreed protocol of care. In addition, these medications were not used in the context of a trial but the positive outcomes encouraged their continued use.…”

Section: Introductionmentioning

confidence: 99%

Haematological changes and metabolic alterations in SARS-CoV-2 infected patients hospitalised at an Infectious Diseases Center, Ibadan, Nigeria

Alonge¹,

Arinola²

2022

Eur J Clin Exp Med

View full text Add to dashboard Cite

Introduction and aim. Following the use of repurposing drugs to successfully manage coronavirus disease 2019 (COVID-19) patients in an Infectious Diseases Center (IDC) in Nigeria, it was imperative to assess haematological changes and metabolic alterations in these patients which may inform recommendations for future use. Material and methods. Blood samples of admitted COVID-19 Nigerian patients during therapeutic management were analysed for haematological- (total white blood cells (WBC), lymphocyte, monocyte, neutrophil, eosinophil, basophil and neutrophil: lymphocyte ratio) and blood chemistry- parameters [total protein, total and conjugated bilirubin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine transaminase (ALT), gamma-glutamyl transferase (GGT), albumin, urea, creatinine, total cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), PO4 3-, Ca2+, uric acid, Na+, K+, Cl- and HCO3 -] using autoanalysers. The percentages of patients having values below, within and above reference ranges were compared using Chi-square test while the mean values at admission were compared with mean values at discharge using Student t-test. Results. The mean values of total protein, albumin, Na+, HCO3 -, uric acid, Ca2+, WBC, platelets, lymphocytes, eosinophils and basophils were significantly increased in COVID-19 patients at discharge compared with COVID-19 patients at admission. Also, more percentages of COVID-19 patients at discharge compared with COVID-19 patients at admission had albumin, ALP, total bilirubin, HDL, Na+, K+, Cl-, HCO3 -, urea, creatinine, WBC, lymphocytes, neutrophils, monocytes, eosinophils and basophils within normal reference intervals. Conclusion. This study showed that most metabolic and haematological derangements were normalised by repurposing drugs in most of the COVID-19 patients at this IDC, thus supporting the continuous use of this therapeutic option.

show abstract

Monocytosis in the acute phase of SARS-CoV-2 infection predicts the presence of anosognosia for cognitive deficits in the chronic phase

Nuber-Champier

Voruz

Alcântara

et al. 2022

Brain, Behavior, & Immunity - Health

View full text Add to dashboard Cite

Cellular Inflammatory Indices in Hospitalized Nigerian COVID-19 Patients

Cited by 7 publications

References 30 publications

Potentials of Varied Inflammatory Indices in the Prediction of COVID-19 Severity Among Nigerians

Potentials of Varied Inflammatory Indices in the Prediction of COVID-19 Severity Among Nigerians

Haematological changes and metabolic alterations in SARS-CoV-2 infected patients hospitalised at an Infectious Diseases Center, Ibadan, Nigeria

Monocytosis in the acute phase of SARS-CoV-2 infection predicts the presence of anosognosia for cognitive deficits in the chronic phase

Contact Info

Product

Resources

About