Cellular localization of cyclic AMP in periodontal tissues during experimental tooth movement in cats

Davidovitch, Zéev; Montgomery, P.C.; Eckerdal, O; Gustafson, Gunnar T.

doi:10.1007/bf02564014

Cited by 54 publications

(11 citation statements)

References 29 publications

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“…14 Other studies assessing changes in rat alveolar bone at sites subjected to opposite strains have noted little or no change in cellular metabolism or synthetic activity, but significant differences in anatomic structure have been observed. 15,16 These results were obtained in vivo at structurally different sites in rat alveolar bone, so they are viewed as complementary to the results reported here. However, no attempt to correlate these results was made.…”

Section: Discussionsupporting

confidence: 75%

Cyclic mechanical strain alters tissue‐factor activity in rat osteosarcoma cells cultured on a titanium substrate

Bledsoe

Slack

Turitto

2004

J Biomedical Materials Res

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Tissue factor (TF), a transmembrane glycoprotein, plays a role in the initiation of blood coagulation at sites of vascular injury. Activated products of coagulation may then enhance inflammatory responses. The present investigation assesses the ability of rat osteosarcoma (UMR-106) cells cultured on titanium alloy (Ti6Al4V) to express differential surface TF activity in response to cyclic mechanical strain. Strains ranged from -2000 micro-strain to +2000 micro-strain, and durations from 5, 10, and 20 min per day over 5 days to 24 h continuous stimulation. ROS cells exhibited significant TF activity as demonstrated by the conversion of Factor X to Factor Xa. Strains of +2000 micro-strain with 5-20-min duration exhibited decreased TF activity with duration from 1.4E-04 nM/cell to 8.7E-05 nM/cell. Additionally, ROS cells stimulated with calcium ionophore (A23187) exhibited at least twice the activity of nonstimulated cells. Strains of +1340 micro-strain with 5-20-min duration exhibited an increasing trend with 4.15E-05 nM/cell to 7.38E-05 nM/cell. Strain direction had no significant effect on TF activity. Thus, both mechanical and chemical stimuli induce differential expression of TF activity by ROS cells cultured on Ti6Al4V, a phenomenon that may potentiate or regulate the inflammatory responses associated with the implantation of orthopedic biomaterials.

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Section: Discussionsupporting

confidence: 75%

Cyclic mechanical strain alters tissue‐factor activity in rat osteosarcoma cells cultured on a titanium substrate

Bledsoe

Slack

Turitto

2004

J Biomedical Materials Res

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“…About 8 years ago, Rodan et al [14] and independently, Davidovitch et al [15], suggested that mechanical stimuli effects on cartilage and bone may be mediated by changes in cyclic nucleotides, one of the ubiquitous mechanisms listed above. Initial evidence collected on bone exposed to mechanical perturbations in vivo and cartilage cells exposed to compressive forces in culture supported these assumptions [ 16 ].…”

Section: Discussionmentioning

confidence: 98%

Tensile forces enhance prostaglandin E synthesis in osteoblastic cells grown on collagen ribbons

1984

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An experimental system has been developed to examine the prostaglandin (PG) production induced by tensile mechanical forces in bone cells cultured on collagen ribbons. Fetal rat calvaria cells (osteoblast-enriched) were grown on collagen ribbons. The collagen ribbons were stretched under culture conditions in a machine that recorded force and displacement. Repeated stretching of the collagen ribbons (8 times, 5-10%, over 2 hours) increased the rate of prostaglandin synthesis approximately 3.5-fold over that of cells on nonstretched ribbons. This system should provide a suitable method to quantitatively study the effect of mechanical forces on various parameters of PG synthesis.

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“…Periodontal cells seem to react to mechanical stimulation by upregulating cellular mediators, such as cyclic AMP (cAMP), that induce proteinkinases to catalyze the phosphorylation of mediator proteins [19]. After several steps, the information about the mechanical stimulation reaches the nucleus, in which two main pathways can be triggered.…”

Section: Molecular and Cellular Regulation Of Tooth Movementmentioning

confidence: 99%

The Role of Hypoxia in Orthodontic Tooth Movement

Niklas

Proff

Gosau

et al. 2013

International Journal of Dentistry

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Orthodontic forces are known to have various effects on the alveolar process, such as cell deformation, inflammation, and circulatory disturbances. Each of these conditions affecting cell differentiation, cell repair, and cell migration, is driven by numerous molecular and inflammatory mediators. As a result, bone remodeling is induced, facilitating orthodontic tooth movement. However, orthodontic forces not only have cellular effects but also induce vascular changes. Orthodontic forces are known to occlude periodontal ligament vessels on the pressure side of the dental root, decreasing the blood perfusion of the tissue. This condition is accompanied by hypoxia, which is known to either affect cell proliferation or induce apoptosis, depending on the oxygen gradient. Because upregulated tissue proliferation rates are often accompanied by angiogenesis, hypoxia may be assumed to fundamentally contribute to bone remodeling processes during orthodontic treatment.

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Cellular localization of cyclic AMP in periodontal tissues during experimental tooth movement in cats

Cited by 54 publications

References 29 publications

Cyclic mechanical strain alters tissue‐factor activity in rat osteosarcoma cells cultured on a titanium substrate

Cyclic mechanical strain alters tissue‐factor activity in rat osteosarcoma cells cultured on a titanium substrate

Tensile forces enhance prostaglandin E synthesis in osteoblastic cells grown on collagen ribbons

The Role of Hypoxia in Orthodontic Tooth Movement

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