Cellular Mechanisms of Oxidative Stress and Action in Melanoma

Venza, Mario; Visalli, Maria; Beninati, Concetta; Gaetano, Giuseppe Valerio De; Teti, Diana

doi:10.1155/2015/481782

Cited by 94 publications

(88 citation statements)

References 146 publications

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“…Melanoma is a form of superficial tumor, with a high malignancy and difficulty to treat (2). Currently, no effective prevention and treatment methods exist (3).…”

Section: Introductionmentioning

confidence: 99%

Safety and toxicology of the intravenous administration of Ang2-siRNA plasmid chitosan magnetic nanoparticles

Shan

Liu

et al. 2016

Molecular Medicine Reports

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This aim of the present study was to investigate the safety and toxicology of intravenous administration of angiopoietin-2 (Ang2)-small interfering (si)RNA plasmid-chitosan magnetic nanoparticles (CMNPs). Ang2-CMNPs were constructed and subsequently administered at different doses to mice and rats via the tail vein. The acute (in mice) and chronic toxicity (in rats) were observed. The results of the acute toxicity assay revealed that the LD50 mice was >707.0 mg·kg-1·d-1, and the general condition of mice revealed no obvious abnormalities. With the exception of the high dose group (254.6 mg·kg-1·d-1), which exhibited partial lung congestion, the other groups exhibited no obvious abnormalities. Results of the chronic toxicity assay demonstrated that the non-toxic dose of Ang2-CMNPs in the rat was >35.35 mg·kg-1·d-1 for 14 days. The rat general condition and blood biochemistry indexes revealed no obvious abnormality. The blood routine indexes and lung/body ratio of each treatment group were higher when compared with the control group. The middle- and high-dose groups exhibited chronic pulmonary congestion, whilst the low-dose and control groups exhibited no abnormality. Similarly, the other organs revealed no obvious abnormality. Ang2-CMNPs have good safety at a certain dose range and may be considered as the target drug carrier.

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“…Melanoma is a form of superficial tumor, with a high malignancy and difficulty to treat (2). Currently, no effective prevention and treatment methods exist (3).…”

Section: Introductionmentioning

confidence: 99%

Safety and toxicology of the intravenous administration of Ang2-siRNA plasmid chitosan magnetic nanoparticles

Shan

Liu

et al. 2016

Molecular Medicine Reports

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show abstract

“…Furthermore, ROS is also known as an important component in migrating and invading cancer cells . Moreover, in melanoma cells, glutathione (GSH) and thioredoxin (TRX) have been established as two major antioxidant systems compared with normal human melanocytes …”

Section: Introductionmentioning

confidence: 99%

Nickel oxide nanoparticles exert selective toxicity on skin mitochondria and lysosomes isolated from the mouse model of melanoma

Rahimi

Naserzadeh

Mousavi

et al. 2019

J Biochem & Molecular Tox

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Nickel oxide nanoparticles (NiO‐NPs) are progressively used for an immense number of new applications in modern industries sectors. Nevertheless, the toxic impact of NiO‐NPs has not been clearly elucidated on human melanoma cell lines at the cellular and molecular level. Hence, this study was designed to examine the in vitro cytotoxicity potentials of NiO‐NPs on malignant cutaneous melanoma (MCM) mitochondria. Results revealed that NiO‐NPs significantly increased reactive oxygen species level, lipid peroxidation, and mitochondrial membrane potential and decreased succinate dehydrogenase activity, glutathione level, and ATP content on skin mitochondria isolated from the mouse model of melanoma compared with the non‐cancerous mouse skin mitochondria. Our results revealed that NiO‐NPs induced lysosomal membrane labialization on mentioned mitochondria. The current study showed that NiO‐NPs could significantly induce selective cytotoxicity on MCM mitochondria. Therefore, this compound may be considered as a promising candidate for further in vivo and clinical studies to reach a new anti‐MCM drug.

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“…24,25 Ultraviolet irradiation is known to be the source of oxidative stress due to the interaction of photons and intracellular chromophore, which can result in genetic damage and activation of redox reaction that can cause oxidative stress of cells. 26,27 To study the antioxidant activity of Moringa extract, we used an ethyl acetate fraction of the extract, which is rich in phenolic acid. Phenolic acid can interact with oxidative oxygen species, donate the hydroxyl ion to the reactive oxygen and lead to the less reactive oxygen form.…”

Section: Discussionmentioning

confidence: 99%

Moringa Oleifera Lam. Leaves Extract Reduces Human T-Cell Hyporesponsiveness and Dna Damage Induced by Oxidative Stress

Kooltheat¹,

Sranujit²,

Luetragoon³

et al. 2017

Int. J. Res. Ayurveda Pharm.

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Chronic inflammatory conditions lead to the generation of excessive reactive oxygen species which can give rise to T cell hyporesponsiveness. Thus there has been an interest to target these mediators with nutrients which have anti-oxidant properties. Accordingly Moringa oleifera extract has been reported to have anti-inflammatory and anti-oxidant properties. We have now examined the effects of Moringa oleifera Lam. on the depressed human T-cell responses, (IL-2 and IL-2 mRNA production) and DNA damage (quantifying the oxidized derivative of deoxyguanosine, 8-OHdG) induced oxidative stress. T-cells treated with oxidative substances, uric acid, aluminum chloride, hydrogen peroxide, and ultraviolet irradiation showed marked reduction in IL-2 production, which was prevented by pre-treating the cells with Moringa extract. These effects correlated with its prevention of the down-regulation of IL2 gene expression and a reduction in the DNA damage caused by oxidative stress. Thus the ability of Moringa extract to reduce inflammation is likely to relate to its ability to prevent T-cell hyporesponsiveness experienced in inflammatory diseases, through an action at the pre-transcriptional level.

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Cellular Mechanisms of Oxidative Stress and Action in Melanoma

Cited by 94 publications

References 146 publications

Safety and toxicology of the intravenous administration of Ang2-siRNA plasmid chitosan magnetic nanoparticles

Safety and toxicology of the intravenous administration of Ang2-siRNA plasmid chitosan magnetic nanoparticles

Nickel oxide nanoparticles exert selective toxicity on skin mitochondria and lysosomes isolated from the mouse model of melanoma

Moringa Oleifera Lam. Leaves Extract Reduces Human T-Cell Hyporesponsiveness and Dna Damage Induced by Oxidative Stress

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