Cellular models of atherosclerosis and their implication for testing natural substances with anti-atherosclerotic potential

The Nutraceutical Dehydrozingerone and Its Dimer Counteract Inflammation‐ and Oxidative Stress‐Induced Dysfunction of In Vitro Cultured Human Endothelial Cells: A Novel Perspective for the Prevention and Therapy of Atherosclerosis

“…Experimental and clinical studies have demonstrated that several nutraceuticals have antiatherogenic effects being able to contrast the biological mechanisms responsible for the formation of the atherosclerotic lesions. These compounds are of interest for the development of new therapeutic approaches because usually they have a good tolerability and less adverse side effects [57]. Our data showing that pretreatment with DHZ and DHZ dimer reduces ROS levels in ECs exposed to oxidative stress are in accordance with previous results demonstrating that CUR improves cell viability and reduces ROS production in HUVEC treated with H 2 O 2 [30].…”

Versicotides D–F, new cyclopeptides with lipid-lowering activities

“…Macrophages uptake oxidized LDL (oxLDL) to accumulate lipids and differentiate into foam cells to form the early lesions that mature into atherosclerotic plaques, thus macrophage foam cell formation is a crucial determinant of atherosclerotic lesion occurrence and is associated with abnormalities in cellular cholesterol homeostasis in macrophages. 22 The bioassay results indicated that compounds 1-3 play important role to prevent the formation of foam cells. In addition, compounds 1-3 decreased the intracellular total cholesterol levels (Fig.…”

Current Safety Data of the Complex Herbal Medicine with Sedative and Cardioprotective Actions

“…Among medical plants containing antiatherosclerotic substances are corn (female inflorescence, with young silk), hawthorn flowers and fruits, rose hips, mountain arnica flowers, Jacob's-ladder roots, elderberry leaves, black chokeberry fruits, common nettle, garlic, beet, and carrots. Herbal infusions will not relieve pain; they have a prophylactic effect, so they should be used for a long time, usually in combination with other preparations [24,25].…”