Cellular Protective Effect and Liposome Formulation for Enhanced Transdermal Delivery of Isoquercitrin

조나래,; 구현아,; 박수아,; 한샛별,; 박수남,

doi:10.15230/scsk.2012.38.2.103

Cited by 8 publications

(3 citation statements)

References 33 publications

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“…Isoquercitrin is the glycoside of quercetin, a type of polyphenol, and is known to have various medical effects such as antioxidant, anti-inflammation, anti-allergy, anti-cancer, hypertension and hyperlipidemia inhibition effects [27]. In the research of Jo [28], it was proved that isoquercitrin has an excellent cell protective effect by increasing the survival rate of the oxidative damage induced HaCaT cells, and the feasibility of isoquercitrin to skin aging by active oxygen was suggested. In this research, it was found that EF breaks down proteins such as collagen and reduces the expression of MMP-9 mRNA which fosters aging.…”

Section: Discussionmentioning

confidence: 99%

Melanin Synthesis Inhibitory Effect of Eriobotryae Folium Extracts & Eriobotryae Folium and Phreatic Water Mixture

et al. 2017

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Objectives:As interests in the beauty of skin is growing continuously, more people are focusing on white and clean skin. Melanin is the major factor that determines skin color. The abnormal concentration of melanin causes various skin diseases such as vitiligo, freckles, and melasma. This study investigated the inhibitory effect of Eriobotryae Folium extracts (EF) with phreatic water (PW) on the melanin synthesis. Methods: The effect of EF on melanin synthesis was evaluated by using mouse melanoma cells (B16F10). To define the mechanisms, real-time PCR and western blot were used. We also evaluated the inhibitory effects of EF and PW on melanin synthesis by using HRM-2 melanin-possessing hairless mice. After UVB irradiation, melanin differences between the skin parts that were treated and untreated with EF and PW. Levels of mRNA were measured by real-time quantitative PCR and histological analysis of the dorsal skin was conducted by hematoxylin and eosin staining. Results: EF inhibited various mechanisms of melanogenesis, and the effect was increased when combined with PW.In vitro experiments have shown that EF inhibited the expressions of tyrosinase related protein-1 (TRP-1) mRNA, tyrosinase mRNA, microphthalmia-associated transcription factor (MITF) mRNA and the tyrosinase inhibitory activation, but it stimulated the extracellular regulated kinase (ERK) mRNA expression. In vivo experiments have shown that EF prevented melanogenesis in the mice dorsal skin and inhibited TRP-1 mRNA expression. Also these effects were increased when combined with PW. Conclusions: EF and PW might be a new and effective treatment for whitening and treating pigmentation of skin.The water was collected from Paradise Spa Dogo, Korea. The component analysis of the PW of DOGO had been conducted in the research of researcher Jang [8], and drinking water test was investigated by Chungnam Institute of Health and Environment, Korea. Sunblock CreamThe sunblock cream was purchased from Medi Spa Sunblock SPF 47/PA ++ 70 ml (HUNUSBIO, INC, Korea) from medical-skincare.co.uk.

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Section: Discussionmentioning

confidence: 99%

Melanin Synthesis Inhibitory Effect of Eriobotryae Folium Extracts & Eriobotryae Folium and Phreatic Water Mixture

et al. 2017

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“…또한 ROS는 피부 기저막에 있는 멜라닌세포의 활성화를 통하여 멜라닌세 포 증식 및 멜라닌 합성을 증가시킨다고 보고되고 있다 [4][5][6][7][8]. 따라서 활성산소를 효율적으로 제거하고 세포 및 조직을 보호하기 위해서는 피부 항산화 방어망 구축 및 항산화 효능이 큰 항산화제의 개발이 절 실히 요구되고 있는 실정이다 [9,10].…”

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Antioxidant and Tyrosinase Inhibitory Activities of Dicaffeoylquinic Acid Derivatives Isolated from Gnaphalium Affine D. DON

Kim¹,

Ha²,

Noh³

et al. 2015

Applied Chemistry for Engineering

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In this study, three dicaffeoylquinic acids (DCQAs) isolated from Gnaphalium affine D. DON. extracts were structurally identified and evaluated for their antioxidant activities, cellular protective effects, and tyrosinase inhibitory activities. The ethyl acetate fraction of G. affine was chromatographed, which yielded 3 DCQA derivatives of 1-3 : 3,5-dicaffoylquinic acid (3,5-DCQA, 1), 4,5-dicaffeoylquinic acid (4,5-DCQA, 2), 1,5-dicaffoylquinic acid (1,5-DCQA, 3). The structure of each compounds was determined using 1 H NMR and MS analyses. Compounds of 1-3 showed strong free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activities (FSC50 = 3.70, 5.80, and 5.50 µM, respectively) compared to those of a commonly used lipophilic antioxidant, (+)-α-tocopherol (21.90 µM). Cellular protective effects of 1-3 compounds on the 1 O2 sensitized photohemolysis of human erythrocytes were similar to (+)-α-tocopherol. 1-3 compounds also exhibited higher tyrosinase inhibitory effects (IC50 = 0.15, 0.16, and 0.13 mM) compared to arbutin (0.33 mM), known as a skin-whitening agent. These results indicate that three DCQA derivatives may be applied as an antioxidant and a skin whitening agent in food or cosmetic industries.

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“…Keywords: Glycyrrhiza uralensis, Glycyrrhiza glabra, DPPH assay, luminol chemiluminescence assay, cellular protective effect [4][5][6][7].…”

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confidence: 99%

Screening of Effective Extraction Conditions for Increasing Antioxidant Activities of Licorice Extracts from Various Countries of Origin

Ha¹,

Lee²,

Kwon³

et al. 2013

Journal of the Society of Cosmetic Scientists of Korea

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In this work, licorice extracts were prepared using various extraction conditions such as extraction solvent, temperature, and time from Glycyrrhiza uralensis (G. uralensis) produced in Korea and China and Glycyrrhiza glabra (G. glabra) in Uzbekistan. The optimum extraction condition was selected from the extraction yields and antioxidative activities of extracts. Korea licorice extracts showed the highest free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activity (46.05%) under the extraction condition of 85% ethanol at 60 ℃ for 6 hours. The prominent ROS (reactive oxygen species) scavenging activity using luminol-dependent chemiluminescence assay and the cellular protective effect against 1 O2 induced cellular membrane damage were also shown from the extracts obtained from the same

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Cellular Protective Effect and Liposome Formulation for Enhanced Transdermal Delivery of Isoquercitrin

Cited by 8 publications

References 33 publications

Melanin Synthesis Inhibitory Effect of Eriobotryae Folium Extracts & Eriobotryae Folium and Phreatic Water Mixture

Melanin Synthesis Inhibitory Effect of Eriobotryae Folium Extracts & Eriobotryae Folium and Phreatic Water Mixture

Antioxidant and Tyrosinase Inhibitory Activities of Dicaffeoylquinic Acid Derivatives Isolated from Gnaphalium Affine D. DON

Screening of Effective Extraction Conditions for Increasing Antioxidant Activities of Licorice Extracts from Various Countries of Origin

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