2017
DOI: 10.1016/j.mce.2016.08.047
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Cellular senescence: Implications for metabolic disease

Abstract: The growing burden of obesity- and aging-related diseases has hastened the search for governing biological processes. Cellular senescence is a stress-induced state of stable growth arrest strongly associated with aging that is aberrantly activated by obesity. The transition of a cell to a senescent state is demarcated by an array of phenotypic markers, and leveraging their context-dependent presentation is essential for determining the influence of senescent cells on tissue pathogenesis. Biomarkers of senescen… Show more

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Cited by 69 publications
(67 citation statements)
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References 136 publications
(173 reference statements)
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“…Individually, D, Q, and F function as senolytic drugs (serving to kill senescent cells) . F and D+Q improve health span by reducing senescent cell burden . D+Q has also been shown to alleviate age‐related bone loss in mice .…”
Section: Discussionmentioning
confidence: 99%
“…Individually, D, Q, and F function as senolytic drugs (serving to kill senescent cells) . F and D+Q improve health span by reducing senescent cell burden . D+Q has also been shown to alleviate age‐related bone loss in mice .…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, metformin increases AMPK and mitochondrial function in multiple tissues, effects that are associated with reductions in oxidative damage, chronic low-grade inflammation and improved health span and lifespan in mice 318 . The AMPK activator quercetin when used in combination with dasatinib has also been shown to exert anti-ageing effects by delaying senescent cell accumulation or reducing senescent cell burden in numerous tissues of rodents 326 . Whether these beneficial effects are replicated in humans and/or are observed with the new generation of direct AMPK activators that do not inhibit mitochondrial function remains to be determined.…”
Section: ) (Table 1)mentioning
confidence: 99%
“…Obesity is a major predictor contributing to type 2 diabetes (T2D), CKD, CVD, and increased mortality [135,136]. Besides being risk factors for CKD, obesity and T2D also contribute to cellular senescence per se [137,138]. Furthermore, the adverse effects of an increased fat mass are at least partly related to the secretion of proteins from adipocytes into the circulation, that is, adipocytokines.…”
Section: Obesity Diabetes Mellitus and Dkdmentioning
confidence: 99%