Cellular Senescence, Neurological Function, and Redox State

Maciel-Barón, Luis Ángel; Moreno-Blas, Daniel; Morales-Rosales, Sandra Lizbeth; González-Puertos, Viridiana Yazmín; López‐Díazguerrero, Norma Edith; Torres, Claudio; Castro-Obregón, Susana; Königsberg, Mina

doi:10.1089/ars.2017.7112

Cited by 34 publications

(30 citation statements)

References 182 publications

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“…The main functions of the endogenous antioxidant enzyme system are to maintain the steady state of ROS in the internal environment and remove excess ROS [ 31 ]. Therefore, numerous researches have shown that treatment with antioxidants could delay the cellular senescence [ 32 ]. Zeng et al [ 33 ] reported that Se-enriched rice could enhance the activity of antioxidant enzymes and prevent the formation of oxidative products.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice

Xie

Jiang

Yao

et al. 2020

BMC Complement Med Ther

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Background: The purpose of this study was to assess the antioxidative activity of selenium-enriched Chrysomyia Megacephala (Fabricius) (C. megacephala) larvae powder (SCML) and its impact on the diversity and structure of intestinal microflora in a mouse model of D-galactose (D-gal)-induced oxidative damage. Methods: Sixty male ICR mice were equally randomized to a normal control (NC) group, a model group, a positive group, a low-dose SCML (L-SCML) group, a mid-dose SCML (M-SCML) group, and a high-dose SCML (H-SCML) group. Animals in NC and model groups received water, animals in the positive group received 40 mg/Kg vitamin E (VE), and those in the three SCML groups received SCML which include 300, 1000 and 3000 μg/Kg selenium (Se) respectively. An oxidative damage model induced by subcutaneous injection of D-gal for 6 weeks via the neck was established. Serum oxidative stress levels and tissue appearance were evaluated. Tissues oxidative stress levels were detected by commercially available kit. Nuclear erythroid 2-related factor (Nrf2) and gut microbiota were determined by western blot and high throughput sequencing 16S rRNA gene respectively. Results: An oxidative damage model was established successfully as represented by a significant elevation of malondialdehyde (MDA) and protein carbonylation, and inhibition of the antioxidants including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC) and glutathione (GSH). It was found that oxidative damage and histological alterations were attenuated, the expression of Kelch-like ECH-associated protein (Keap1) was decreased, and the expression of Nrf2 and hemeoxygenase-1 (HO-1) was increased after SCML treatment. In addition, significant changes were observed in the gut microbiota, including Proteobacteria and the ratio of Bacteroidetes to Firmicutes at the phylum level, as well as Helicobacter, Clostridium and Lactobacillus at the genus level.

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Section: Discussionmentioning

confidence: 99%

Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice

Xie

Jiang

Yao

et al. 2020

BMC Complement Med Ther

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“…Oxidative stress is one of the major factors to contribute to cellular senescence, and a typical feature of senescence is a shift to a prooxidant redox state. Therefore, numerous researches have shown that treatment with antioxidants could delay the cellular senescence [38]. Moreover, SOD, CAT, and VE are the important members of this antioxidant system [10].…”

Section: Discussionmentioning

confidence: 99%

Matrine Attenuates D‐Galactose‐Induced Aging‐Related Behavior in Mice via Inhibition of Cellular Senescence and Oxidative Stress

Sun

Yang

Zhao

et al. 2018

Oxidative Medicine and Cellular Longevity

103

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The present study was designed to evaluate the effects of matrine (MAT) on D-galactose- (D-gal-) induced aging and relative mechanism. Vitamin E at the dose of 100 mg/kg was used as a standard positive control. MAT significantly improved the D-gal-induced recognition and spatial memory impairment in novel object recognition and Y maze tests, and exercise endurance decreased in the weight-loaded swimming test at 2 and 10 mg/kg. We found that D-gal treatment induced noticeably aging-related changes such as reducing thymus coefficients, increasing the pathological injury and cellular senescence of liver, spleen, and hippocampus, as well as an increase in cyclin-dependent kinase inhibitor p16, p19, and p21 gene expression and the interleukin-1β expression in the liver and hippocampus. MAT showed effective protection on such changes. Furthermore, MAT decreased the oxidative stress of the liver, plasma, and brain, as evidenced by increased total antioxidant capacity, total superoxide dismutase, and catalase activities and decreased the malondialdehyde level. Additionally, there was a significant positive correlation between swimming time in weight-loaded swimming time and thymus index. MAT ameliorated aging-related disorder caused by D-gal through the inhibition of both cellular senescence and oxidative stress. The study provides further evidence for drug development of MAT for prevention or treatment of the aging-associated disorder.

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“…Senescent cells are detectable in the mammalian brain, specifically in replication competent glial cells, where they could contribute to neurodegeneration by secreting pro‐inflammatory SASP factors and/or deregulating cellular crosstalk useful for the structural and functional neuron‐glial interaction that maintains neuronal homeostasis . Senescence markers have been observed in all the different cell populations of the brain, including neurons and components of innate immunity, and they correlate with normal or pathological aging conditions . Indeed, immune responses in the CNS are common, despite its perception as a site of immune privilege .…”

Section: Introductionmentioning

confidence: 99%

Innate immunity and cellular senescence: The good and the bad in the developmental and aged brain

Spinelli

Martucciello

Nori

et al. 2018

Journal of Leukocyte Biology

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Ongoing studies evidence cellular senescence in undifferentiated and specialized cells from tissues of all ages. Although it is believed that senescence plays a wider role in several stress responses in the mature age, its participation in certain physiological and pathological processes throughout life is coming to light. The "senescence machinery" has been observed in all brain cell populations, including components of innate immunity (e.g., microglia and astrocytes). As the beneficial versus detrimental implications of senescence is an open question, we aimed to analyze the contribution of immune responses in regulatory mechanisms governing its distinct functions in healthy (development, organogenesis, danger patrolling events) and diseased brain (glioma, neuroinflammation, neurodeneration), and the putative connection between cellular and molecular events governing the 2 states. Particularly this review offers new insights into the complex roles of senescence both as a chronological event as age advances, and as a molecular mechanism of brain homeostasis through the important contribution of innate immune responses and their crosstalk with neighboring cells in brain parenchyma. We also highlight the impact of the recently described glymphatic system and brain lymphatic vasculature in the interplay between peripheral and central immune surveillance and its potential implication during aging. This will open new ways to understand brain development, its deterioration during aging, and the occurrence of several oncological and neurodegenerative diseases.

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Cellular Senescence, Neurological Function, and Redox State

Cited by 34 publications

References 182 publications

Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice

Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice

Matrine Attenuates D‐Galactose‐Induced Aging‐Related Behavior in Mice via Inhibition of Cellular Senescence and Oxidative Stress

Innate immunity and cellular senescence: The good and the bad in the developmental and aged brain

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