Matrine Attenuates D‐Galactose‐Induced Aging‐Related Behavior in Mice via Inhibition of Cellular Senescence and Oxidative Stress

Abstract

The present study was designed to evaluate the effects of matrine (MAT) on D-galactose- (D-gal-) induced aging and relative mechanism. Vitamin E at the dose of 100 mg/kg was used as a standard positive control. MAT significantly improved the D-gal-induced recognition and spatial memory impairment in novel object recognition and Y maze tests, and exercise endurance decreased in the weight-loaded swimming test at 2 and 10 mg/kg. We found that D-gal treatment induced noticeably aging-related changes such as reducing thymus coefficients, increasing the pathological injury and cellular senescence of liver, spleen, and hippocampus, as well as an increase in cyclin-dependent kinase inhibitor p16, p19, and p21 gene expression and the interleukin-1β expression in the liver and hippocampus. MAT showed effective protection on such changes. Furthermore, MAT decreased the oxidative stress of the liver, plasma, and brain, as evidenced by increased total antioxidant capacity, total superoxide dismutase, and catalase activities and decreased the malondialdehyde level. Additionally, there was a significant positive correlation between swimming time in weight-loaded swimming time and thymus index. MAT ameliorated aging-related disorder caused by D-gal through the inhibition of both cellular senescence and oxidative stress. The study provides further evidence for drug development of MAT for prevention or treatment of the aging-associated disorder.

Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress

“…Oxidative stress promoted cellular senescence [35]. A large number of studies have used the D-gal-induced ageing model for screening of anti-ageing compounds [26][27][28][29][32][33][34]. In our study, the D-gal-induced ageing model was well-established…”

“…d-Gal can cause systematic ageing-related changes, such as hepatic and brain injury, a decline in immune function [26][27][28][29], learning and memory impairment, and fatigue in behavior studies [26,27]. Parallel histopathological features of the liver, spleen, and hippocampus were observed similarly in the d-gal-induced ageing and naturally aging groups [30].…”

A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine

“…Meanwhile, MT suppressed the activation of p19/p21 and p16 pathways in the liver and hippocampus of D-gal-induced mice. These results suggest that MT plays an anti-aging role by inhibiting oxidative stress and cell senescence ( Sun et al., 2018 ).…”

Resveratrol ameliorates thymus senescence changes in D‐galactose induced mice

“…5,6 It causes changes similar to natural aging, including biochemical changes, low immune function, cell growth reduction, decreased reproductive capacity and thymus coefficient. 7 Resveratrol (3,4',5-trans-trihydroxystilbene, RSV), an antioxidant, exists in numerous plants and red wine. Previous studies have shown that RSV has an antioxidant and anti-inflammatory effect.…”