Cellular Therapy for Sepsis: A New Hope?*

Enkhbaatar, Perenlei

doi:10.1097/ccm.0000000000002147

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…2), we unexpectedly found that SPM also stimulate phagocytosis of bacteria as well as their killing and clearance (Chiang et al, 2012; Spite et al, 2009). These counterintuitive results are confirmed by others (Russell and Schwarze, 2014; Lee and Zeldin, 2015) and are associated with the ability of SPM to clear infections in animals (Chiang et al, 2012; Codagnone et al, 2017), and thus a potential new approach to treat sepsis (Buechler et al, 2017; Enkhbaatar, 2016). We monitored SPM profiles in sepsis patients where their temporal profiles correlate to survival and outcomes (Dalli et al, 2017b) ( vide infr a).…”

Section: Introductionsupporting

confidence: 67%

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

Serhan

Chiang

Dalli

2018

Molecular Aspects of Medicine

205

237

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While protective, the acute inflammatory response when uncontrolled can lead to further tissue damage and chronic inflammation that is now widely recognized to play important roles in many commonly occurring diseases, such as cardiovascular disease, neurodegenerative diseases, metabolic syndrome, and many other diseases of significant public health concern. The ideal response to initial challenges of the host is complete resolution of the acute inflammatory response, which is now recognized to be a biosynthetically active process governed by specialized pro-resolving mediators (SPM). These chemically distinct families include lipoxins, resolvins, protectins and maresins that are biosynthesized from essential fatty acids. The biosynthesis and complete stereochemical assignments of the major SPM are established, and new profiling procedures have recently been introduced to document the activation of these pathways in vivo with isolated cells and in human tissues. The active resolution phase leads to tissue regeneration, where we've recently identified new molecules that communicate during resolution of inflammation to activate tissue regeneration in model organisms. This review presents an update on the documentation of the roles of SPMs and the biosynthesis and structural elucidation of novel mediators that stimulate tissue regeneration, coined conjugates in tissue regeneration. The identification and actions of the three families, maresin conjugates in tissue regeneration (MCTR), protectin conjugates in tissue regeneration (PCTR), and resolvin conjugates in tissue regeneration (RCTR), are reviewed here. The identification, structural elucidation and the pathways and biosynthesis of these new mediators in tissue regeneration demonstrate the host capacity to protect from collateral tissue damage, stimulate clearance of bacteria and debris, and promote tissue regeneration via endogenous pathways and molecules in the resolution metabolome.

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Section: Introductionsupporting

confidence: 67%

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

Serhan

Chiang

Dalli

2018

Molecular Aspects of Medicine

205

237

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“…Sepsis can be fatal and represents a leading cause of death in the intensive care unit (ICU) (1). Much research has been dedicated to this devastating disease offering various therapeutic strategies (2). Unfortunately, no specific pharmacological therapy for sepsis has been approved for clinical use to date.…”

Section: Introductionmentioning

confidence: 99%

Gender-Related Variations in Pathophysiological Responses to Methicillin-Resistant Staphylococcus Aureus Pneumonia and Sepsis

Homma

Liu

Niimi

et al. 2023

Shock

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In preclinical studies, the protective effects of female sex hormones and the immunosuppressive effects of male sex hormones were demonstrated. However, gender-related differences in multiorgan failure and mortality in clinical trials have not been consistently explained. This study aims to investigate gender-related differences in the development and progression of sepsis using a clinically relevant ovine model of sepsis. Adult Merino male (n=7) and female (n=7) sheep were surgically prepared with multiple catheters before the study. To induce sepsis, bronchoscopy instilled methicillin-resistant Staphylococcus aureus into sheep's lungs. The time from the bacterial inoculation until the modified Quick Sequential Organ Failure Assessment (q-SOFA) score became positive was measured and analyzed primarily. We also compared the SOFA score between these male and female sheep over time. Survival, hemodynamic changes, the severity of pulmonary dysfunction, and microvascular hyperpermeability were also compared. The time from the onset of bacterial inoculation to the positive q-SOFA in male sheep was significantly shorter than in female sheep. Mortality was not different between these sheep (14% vs. 14%). There were no significant differences in hemodynamic changes and pulmonary function between the two groups at any time point. Similar changes in hematocrit, urine output, and fluid balance were observed between females and males. The present data indicate that the onset of multiple organ failure and progression of sepsis is faster in male sheep than in female sheep, even though the severity of cardiopulmonary function is comparable over time. Further studies are warranted to validate the above results.

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Cellular Therapy for Sepsis: A New Hope?*

Cited by 2 publications

References 17 publications

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

Gender-Related Variations in Pathophysiological Responses to Methicillin-Resistant Staphylococcus Aureus Pneumonia and Sepsis

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