Cellular therapy for treatment of spinal cord injury in Zebrafish model

Tayanloo-Beik, Akram; Rabbani, Zahra; Soveyzi, Faezeh; Alavi-Moghadam, Sepideh; Rezaei‐Tavirani, Mostafa; Goodarzi, Parisa; Arjmand, Babak; Larijani, Bagher

doi:10.1007/s11033-020-06126-7

Cited by 13 publications

(8 citation statements)

References 49 publications

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“…Cellular therapy has profound significance in the treatment of chronic diseases [ 152 ]. However, the immune system response caused by allogeneic materials leads to the formation of the fibrous capsules at the implantation site, which cuts off the supply of nutrients and eventually leads to cell death [ 153 ].…”

Section: Biomedical Applications Of Zwitterionic Hydrogelsmentioning

confidence: 99%

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Liu

Tang

et al. 2022

Gels

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Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

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Section: Biomedical Applications Of Zwitterionic Hydrogelsmentioning

confidence: 99%

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Liu

Tang

et al. 2022

Gels

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“…As an example, Saccharomyces cerevisiae is a unicellular model and is unable to show complex phenotypes of ALS and advanced cross-talks between motor neurons and their environmental cells. The nervous systems of Drosophila melanogaster and Caenorhabditis elegans are anatomically different from that of human beings and the CNS of zebrafish lacks upper motor neurons ( 55 , 56 , 65 ). On the other hand, the immune system of animals has shown significantly different responses when being exposed to new pharmaceutical agents ( 36 ).…”

Section: Als In Vivo Modeling Platformsmentioning

confidence: 99%

Organ on a Chip: A Novel in vitro Biomimetic Strategy in Amyotrophic Lateral Sclerosis (ALS) Modeling

et al. 2022

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Amyotrophic lateral sclerosis is a pernicious neurodegenerative disorder that is associated with the progressive degeneration of motor neurons, the disruption of impulse transmission from motor neurons to muscle cells, and the development of mobility impairments. Clinically, muscle paralysis can spread to other parts of the body. Hence it may have adverse effects on swallowing, speaking, and even breathing, which serves as major problems facing these patients. According to the available evidence, no definite treatment has been found for amyotrophic lateral sclerosis (ALS) that results in a significant outcome, although some pharmacological and non-pharmacological treatments are currently applied that are accompanied by some positive effects. In other words, available therapies are only used to relieve symptoms without any significant treatment effects that highlight the importance of seeking more novel therapies. Unfortunately, the process of discovering new drugs with high therapeutic potential for ALS treatment is fraught with challenges. The lack of a broad view of the disease process from early to late-stage and insufficiency of preclinical studies for providing validated results prior to conducting clinical trials are other reasons for the ALS drug discovery failure. However, increasing the combined application of different fields of regenerative medicine, especially tissue engineering and stem cell therapy can be considered as a step forward to develop more novel technologies. For instance, organ on a chip is one of these technologies that can provide a platform to promote a comprehensive understanding of neuromuscular junction biology and screen candidate drugs for ALS in combination with pluripotent stem cells (PSCs). The structure of this technology is based on the use of essential components such as iPSC- derived motor neurons and iPSC-derived skeletal muscle cells on a single miniaturized chip for ALS modeling. Accordingly, an organ on a chip not only can mimic ALS complexities but also can be considered as a more cost-effective and time-saving disease modeling platform in comparison with others. Hence, it can be concluded that lab on a chip can make a major contribution as a biomimetic micro-physiological system in the treatment of neurodegenerative disorders such as ALS.

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“…In accordance with various introduced limitations, as the epicenter of regenerative medicine, mesenchymal stem cells (MSCs) have been widely investigated and applied, and also have appeared throughout this area as a strong and commonly used cell source. Their capacity to differentiate into diverse cell (Aghayan et al, 2014b;Larijani et al, 2014Larijani et al, , 2015Larijani et al, , 2021Goodarzi et al, 2018a,b;Payab et al, 2018;Arjmand et al, 2019;Abedi et al, 2020;Tayanloo-Beik et al, 2021). These features makes them the most suitable stem cell approaches among many of them (Azmi et al, 2020).…”

Section: Regenerative Medicine and Cell-based Treatmentsmentioning

confidence: 99%

“…Their capacity to differentiate into diverse cell lineages, migration, and cellular regulator secretion together with immunosuppressive and immunomodulatory potential of MSC secretome are the features that make them extremely valuable. On the other hand, their isolation is almost easy and does not have significant ethical concerns ( Aghayan et al, 2014b ; Larijani et al, 2014 , 2015 , 2021 ; Goodarzi et al, 2018a , b ; Payab et al, 2018 ; Arjmand et al, 2019 ; Abedi et al, 2020 ; Tayanloo-Beik et al, 2021 ). These features makes them the most suitable stem cell approaches among many of them ( Azmi et al, 2020 ).…”

Section: Regenerative Medicine and Cell-based Treatmentsmentioning

confidence: 99%

COVID-19 Pathology on Various Organs and Regenerative Medicine and Stem Cell-Based Interventions

Arjmand

Alavi-Moghadam

Roudsari

et al. 2021

Front. Cell Dev. Biol.

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Severe acute respiratory syndrome-coronavirus 2, a novel betacoronavirus, has caused the global outbreak of a contagious infection named coronavirus disease-2019. Severely ill subjects have shown higher levels of pro-inflammatory cytokines. Cytokine storm is the term that can be used for a systemic inflammation leading to the production of inflammatory cytokines and activation of immune cells. In coronavirus disease-2019 infection, a cytokine storm contributes to the mortality rate of the disease and can lead to multiple-organ dysfunction syndrome through auto-destructive responses of systemic inflammation. Direct effects of the severe acute respiratory syndrome associated with infection as well as hyperinflammatory reactions are in association with disease complications. Besides acute respiratory distress syndrome, functional impairments of the cardiovascular system, central nervous system, kidneys, liver, and several others can be mentioned as the possible consequences. In addition to the current therapeutic approaches for coronavirus disease-2019, which are mostly supportive, stem cell-based therapies have shown the capacity for controlling the inflammation and attenuating the cytokine storm. Therefore, after a brief review of novel coronavirus characteristics, this review aims to explain the effects of coronavirus disease-2019 cytokine storm on different organs of the human body. The roles of stem cell-based therapies on attenuating cytokine release syndrome are also stated.

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Cellular therapy for treatment of spinal cord injury in Zebrafish model

Cited by 13 publications

References 49 publications

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Organ on a Chip: A Novel in vitro Biomimetic Strategy in Amyotrophic Lateral Sclerosis (ALS) Modeling

COVID-19 Pathology on Various Organs and Regenerative Medicine and Stem Cell-Based Interventions

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