Cellulose acetate electrospun nanofibers for drug delivery systems: Applications and recent advances

Khoshnevisan, Kamyar; Maleki, Hassan; Samadian, Hadi; Shahsavari, Shadab; Sarrafzadeh, Mohammad‐Hossein; Larijani, Bagher; Dorkoosh, Farid Abedin; Haghpanah, Vahid; Khorramizadeh, Mohammad Reza

doi:10.1016/j.carbpol.2018.06.072

Cited by 274 publications

(132 citation statements)

References 97 publications

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…Licznie przeprowadzone badania dotyczyły możli wości zastosowania w roli nośnika leków nanowłókien z octanu celulozy (CA), co szczegółowo w swojej pracy przeglądowej opisali Khoshnevisan i współpr. [50]. Do nanowłókien wytworzonych z CA wprowadzano róż ne środki przeciwdrobnoustrojowe (np.…”

Section: Systemy Uwalniania Lekówunclassified

See 1 more Smart Citation

Electrospun polymer nanofibers for medical applications

Winkler¹,

Maliszewska²,

Czapka³

2020

Polimery

View full text Add to dashboard Cite

Streszczenie: Nanowłókna polimerowe wzbudzają obecnie ogromne zainteresowanie ze względu na ich potencjalne wykorzystanie w różnych procesach technologicznych, np. w produkcji tkanin lub wy twarzaniu membran. Włókna te wykazują wyjątkowe właściwości, takie jak: duży stosunek powierzch ni do objętości oraz duża porowatość. Znanych jest kilka metod wytwarzania nanowłókien, jednak ze względu na prostotę, powtarzalność i niewielkie koszty, najpowszechniej stosowane jest przędzenie elektrostatyczne. Przedstawiono przegląd najnowszych osiągnięć w zakresie zastosowań nanowłókien polimerowych w medycynie, obejmujący zagadnienia materiałów opatrunkowych, uwalniania sub stancji aktywnych oraz inżynierii tkankowej.Słowa kluczowe: elektroprzędzenie, nanowłókna, zastosowania medyczne.Abstract: Polymer nanofibers are currently of great interest in terms of their potential use in various technological processes, e.g. in the manufacture of textiles or membranes. These fibers are characterized by extraordinary properties such as high surface to volume ratio and high porosity. There are several methods of manufacturing nanofibers, but for reasons of simplicity, repeatability and low cost, elec trostatic spinning is the most common. The article presents a review of the latest developments in the application of polymer nanofibers in medicine, including such issues as bandage materials, release of active substances and tissue engineering.

show abstract

Section: Systemy Uwalniania Lekówunclassified

“…ketoprofen, sylimarynę oraz naproksen). Uzyskane wyniki jednoznacznie po twierdziły skuteczność tego typu nanowłókien w charak terze nośników substancji aktywnych [50]. Powszechnie stosowanym polimerem jest również PCL.…”

Section: Systemy Uwalniania Lekówunclassified

Electrospun polymer nanofibers for medical applications

Winkler¹,

Maliszewska²,

Czapka³

2020

Polimery

View full text Add to dashboard Cite

show abstract

“…There are various Cur forms to enhance its bioactivity and bioavailability, among which nanotechnology‐related formulas are of great importance in drug delivery systems and RG medicine. In many studies, Cur is loaded onto a synthesized polymer such as chitosan (CS), polyvinyl alcohol (PVA), poly(ε‐caprolactone) (PCL), poly(2‐hydroxyethyl methacrylate) (HEMA), poly( dl ‐lactic‐co‐glycolic) acid, poly(lactic acid), cellulose acetate and their copolymers and blends . CS is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound‐dressing applications, and PVA is also a type of nontoxic, water‐soluble and biocompatible synthetic polymer .…”

Section: Introductionmentioning

confidence: 99%

Wound healing improvement by curcumin‐loaded electrospun nanofibers and BFP‐MSCs as a bioactive dressing

Golchin

Hosseinzadeh

Jouybar

et al. 2020

Polymers for Advanced Techs

View full text Add to dashboard Cite

Wound healing, one of the most complex processes of the body involving the cooperation of several important biomolecules and pathways, is one of the major therapeutic and economic issues in regenerative medicine. The present study aimed to introduce a novel electrospun curcumin (Cur)-incorporated chitosan/polyvinyl alcohol/carbopol/polycaprolactone nanofibrous composite for concurrent delivery of the buccal fat pad-derived mesenchymal stem cells (BFP-MSCs) and Cur to a fullthickness wound on the mouse model. Scaffolds were characterized structurally using scanning electron microscopy (SEM), fluorescence microscopy imaging and Fouriertransform infrared spectroscopy, and toxicity of the scaffolds was also evaluated after BFP-MSC seeding by SEM imaging and 3-(4,5 dimethyiazol-2-1)-2-5-diphenyl tetrazolium bromide (MTT) assay. Then, its influence on the wound-healing process was investigated as a wound dressing for a full-thickness skin defect in mouse model.Results demonstrated that the designed composite scaffolds have the capability for cell seeding and support their growth and proliferation. Macroscopic and histopathological characteristics were evaluated at the end of the 7 and 14 days after surgery, and their results showed that our designed scaffold groups accelerated the woundhealing process compared with the control group. Among those, scaffold/Cur, scaffold/Cur/BFP-MSC and scaffold/BFP-MSC groups demonstrated more wound repair efficacy. These results indicated that the combined grafts can be used to improve the wound-healing process, and therefore, the electrospun nanofibers presented in this study, Cur and BFP-MSC together, were demonstrated to have promising potential for wound-dressing applications. K E Y W O R D S chitosan/polyvinyl alcohol/carbopol/polycaprolactone, curcumin, electrospun nanofibers, mesenchymal stem cells, regenerative medicine, wound healing

show abstract

“…These studies require tailored, engineered and repeatable electrical properties of the scaffolds, while also ensuring high biocompatibility, proper cell attachment, adequate mechanical integrity and tissue integration in addition to the golden missing chain between these properties, which is ensuring reproducibility with low fabrication costs [16][17][18]. The latter property is still highly sought despite the development of numerous platforms with significant and promising results [16,19].…”

Section: Introductionmentioning

confidence: 99%

Simple and Robust Fabrication and Characterization of Conductive Carbonized Nanofibers Loaded with Gold Nanoparticles for Bone Tissue Engineering Applications

Nekounam

Gholizadeh

Allahyari

et al. 2020

Preprint

View full text Add to dashboard Cite

Bone tissue engineering is a new and applicable emerging approach to repair the bone defects. In this regard, designing and robust fabrication of tissue engineering scaffolds that could provide an appropriate environment for cell proliferation and differentiation is of high interest.Electrical conductive scaffolds which provide a substrate for stimulating cell growth and differentiation through a physiologically relevant physical signaling, electrical stimulation, has shown a highly promise in this approach. In this paper, we fabricated carbon nanofiber/gold nanoparticle (CNF/GNP) conductive scaffolds using two distinct methods; blending electrospinning in which gold nanoparticles were blended with electrospinning solution and electrospun, and electrospinning/electrospraying in which gold nanoparticle was electrosprayed simultaneously with electrospinning. The obtained electrospun mats underwent stabilization/carbonization process to prepare CNF/GNP scaffolds. The scaffolds were characterized by SEM, XRD, and Raman spectroscopy. SEM characterizations showed improved morphology and a slight decrease in the diameter of the spinned and sprayed nanofibers with moderate concentrations (from 178.66 ± 38.40 nm to 157.94 ± 24.14 nm and 120.81 ± 13.77 nm, respectively), In the electrosprayed form, better size distributions of nanofibers and less adhesion between individual fibers was observed, while XRD analysis confirmed the crystal structure of the nanofibers. Raman spectroscopy revealed enhancement in the graphitization of the structure, and the electrical conductivity of the structure improved by up to 29.2% and 81% in electrospraying and blending electrospinning modes, respectively. Indirect MTT and LDH toxicity assays directly were performed to assess MG63 cell toxicity, but no significant toxicity was observed and the scaffolds did not adversely affect cell proliferation.Overall, it can be concluded that in early tests, this structure have significant potential for bone tissue engineering applications.

show abstract

Cellulose acetate electrospun nanofibers for drug delivery systems: Applications and recent advances

Cited by 274 publications

References 97 publications

Electrospun polymer nanofibers for medical applications

Electrospun polymer nanofibers for medical applications

Wound healing improvement by curcumin‐loaded electrospun nanofibers and BFP‐MSCs as a bioactive dressing

Simple and Robust Fabrication and Characterization of Conductive Carbonized Nanofibers Loaded with Gold Nanoparticles for Bone Tissue Engineering Applications

Contact Info

Product

Resources

About