Cellulose-Based Hydrogels as Biomaterials

Sezer, Serdar; Şahin, İsa; Öztürk, Kevser; Şanko, Vildan; Kocer, Zeynep; Sezer, Ümran Aydemir

doi:10.1007/978-3-319-76573-0_40-1

Cited by 3 publications

(4 citation statements)

References 140 publications

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“…Cellulose is the most known biodegradable polymer, being the main component of all vegetable fibers, with properties ranging from low cost and biocompatibility to high mechanical and thermal stability, which makes it a very promising and attractive polymer for various applications [54][55][56][57]. Its only drawback is its low solubility, which restricts its use especially in the biomedical and pharmaceutical fields, but this disadvantage can be overcome by obtaining cellulose derivatives by various chemical modification procedures, such as esterification, etherification, or oxidation [29,54,58,59]. Cellulose and cellulose derivatives are used in the pharmaceutical industries as "excipients" to control the rate of drug release and to reach the correct drug concentration [60].…”

Section: Cellulose and Cellulose Derivative-based Hydrogels Propertiesmentioning

confidence: 99%

“…In the pharmaceutical area, the most used esters are cellulose acetate (CA), cellulose nitrate, cellulose acetate phthalate (CAS), hydroxypropyl methylcellulose phthalate (HPMCP), and hydroxypropyl methylcellulose acetate succinate (HPMC-AS). These esters are insoluble in water and have good characteristics for film-forming, useful properties for standard coatings [54]. Moreover, cellulose esters are non-toxic, stable, are not absorbed from GIT and have the relatively high permeability to water, properties which are essential in drug-delivery applications [19].…”

Section: Cellulose and Cellulose Derivative-based Hydrogels Propertiesmentioning

confidence: 99%

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Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

140

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Hydrogels, three-dimensional (3D) polymer networks, present unique properties, like biocompatibility, biodegradability, tunable mechanical properties, sensitivity to various stimuli, the capacity to encapsulate different therapeutic agents, and the ability of controlled release of the drugs. All these characteristics make hydrogels important candidates for diverse biomedical applications, one of them being drug delivery. The recent achievements of hydrogels as safe transport systems, with desired therapeutic effects and with minimum side effects, brought outstanding improvements in this area. Moreover, results from the utilization of hydrogels as target therapy strategies obtained in clinical trials are very encouraging for future applications. In this regard, the review summarizes the general concepts related to the types of hydrogel delivery systems, their properties, the main release mechanisms, and the administration pathways at different levels (oral, dermal, ocular, nasal, gastrointestinal tract, vaginal, and cancer therapy). After a general presentation, the review is focused on recent advances in the design, preparation and applications of innovative cellulose-based hydrogels in controlled drug delivery.

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Section: Cellulose and Cellulose Derivative-based Hydrogels Propertiesmentioning

confidence: 99%

Section: Cellulose and Cellulose Derivative-based Hydrogels Propertiesmentioning

confidence: 99%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

140

View full text Add to dashboard Cite

show abstract

“…In the pharmaceutical sector, the most often used esters include cellulose acetate (CA), cellulose nitrate, cellulose acetate phthalate (CAS), hydroxypropylmethylcellulose phthalate (HPMCP), and hydroxypropyl methylcellulose acetate succinate (HPMC-AS). These esters can create beneficial films and coatings and are insoluble in water [104]. Additionally, cellulose esters possess properties including non-toxicity, stability, gastrointestinal tract abstinence, and relatively highwater permeability that are required for drug delivery systems [105].…”

Section: Problems With Peg Polymersmentioning

confidence: 99%

Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review

Aldaais¹

2023

Preprint

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Due to their distinct physical, chemical, and biological characteristics, biopolymers, in particular Poly Ethylene Glycol (PEG) and Cellulose, are frequently used in biomedical medicine as drug or vaccine delivery systems. In this study, we have done a systematic review and a meta-analysis to compare current developments in many PEG and cellulose-based hydrogels, including double network hydrogels, injectable hydrogels, sliding hydrogels, conductive hydrogels, responsive hydrogels, and nanocomposite hydrogels. The pharmacokinetic properties, including physicochemical properties, biocompatibility, biodegradability, temperature, and pH, have been studied as these critical factors are to be considered for deciding the suitability of the drug for delivery. Moreover, the study has evaluated the controlled-release parameters such as half-life, circulation time, maximum release percentage of loaded drug released, burst release, maximum release, and drug-release kinetics. Finally, the efficacy and immune response of hydrogel was studied for future choice, including the cellulose hydrogel system in COVID-related long-term vaccine delivery. The finding revealed that cellulose-based hydrogel is effective for vaccine delivery.

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“…25 Another aliphatic polyester, poly(glycolic acid) (PGA), known for its fast hydrolysis rate without methyl side chain, will be quickly degraded in vivo in about 2 months and completely disappear within 10-18 weeks. [26][27][28][29] Its simple and regular molecular structure allows PGA to have a high degree of crystallinity, typically 40%-50% that makes it can only dissolve in a few polar solvents, such as hexafluoroisopropanol. The copolymerization of the glycolide (GA) and LLA monomers disrupts the regularity of the original homopolymer molecular chain, therefore, the crystallinity is greatly reduced.…”

Section: Introductionmentioning

confidence: 99%

Structure, properties, and in vitro degradation behavior of biodegradable poly(L‐lactic acid)‐trimethylene carbonate‐glycolide terpolymer

Xia

Zhang

et al. 2022

J of Applied Polymer Sci

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For biodegradable medical implants, it is critical to match the degradation rate of the material with the lesion healing rate of the tissue defect. Here, we report the synthesis of poly(L-lactic acid) (PLLA)-trimethylene carbonate (TMC)glycolide (GA) terpolymers with various monomer feeding ratios of L-lactide, TMC, and GA. The terpolymers were prepared through ring-opening polymerization with the purpose to improve degradation and mechanical properties of the terpolymers for biomedical applications. The influence of various GA contents in PLLA-TMC-GA terpolymers on the chain structure and their in vitro degradation performances were evaluated by using gel permeation chromatography, differential scanning calorimetry, X-ray diffraction, 1 H nuclear magnetic resonance, and tensile tests. Compared with pure PLLA, the degradation rate of terpolymers increased with the increase of GA content, because GA segments, which have a faster hydrolysis rate, not only effectively disrupt the regularity of LLA segment, but also increase the probability of chains scission during the degradation process. In a 28-week long degradation study, the mass loss of PLLA-TMC-GA terpolymers was about 36%, which is a faster rate than reported for pure PLLA. Therefore, it is possible to tailor the copolymer chain structures by varying the ratio of GA in the terpolymer to balance its degradation rate with body's lesion healing rate.

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Cellulose-Based Hydrogels as Biomaterials

Cited by 3 publications

References 140 publications

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review

Structure, properties, and in vitro degradation behavior of biodegradable poly(L‐lactic acid)‐trimethylene carbonate‐glycolide terpolymer

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