Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials

Abstract

In this paper, the use of ultrathin cellulose supports as platform for the incorporation of analgesic drugs in wound dressings is proposed. As a model drug, diclofenac (DCF) is chosen, which is commonly used in pain easing medical treatments. The DCF containing cellulose films are prepared by mixing solutions of trimethylsilyl cellulose (DS Si :2.5) with DCF dissolved in THF. After depositing the material on a solid surface by spin-coating, the films are subjected to vapor-phase hydrolysis using 3 M HCl in order to achieve regeneration of cellulose. The release of DCF from these films over time is studied by UV-Vis. Upon deposition of additional layers of cellulose that do not contain DCF, the release from these films can be decelerated significantly. The release kinetics from these films is very similar to those of viscose fibers impregnated with DCF solutions. These studies indicate a potential use of cellulose thin films as model platform for viscose based wound dressings.

Functional wound dressing materials with highly tunable drug release properties

“…[30][31][32] Mostly NSAIDs are taken through systemic administration (i.e., in the form of pills), whereas several approaches have been and are researched towards their integration into different wound dressing formulations. [33][34][35][36] Although antibiotics are not the preferred type of drugs for local treatment due to possible resistance acquisition of commensal bacteria, there are several interesting studies available about preparation of dressing, combining NSAIDs and antimicrobials. [37][38][39] The purpose of this study was therefore to prepare wound dressing materials with incorporated NSAIDs and to study their efficiency related to material performance and drug release.…”

Novel chitosan/diclofenac coatings on medical grade stainless steel for hip replacement applications

“…At 1577 cm −1 , R=C=O stretching vibration is observed. Additional peaks corresponding to R–C=O stretching and CH 2 bending are visible at 1305 and 1462 cm −1  6172. Although small in intensity, these peaks are visible for all samples with DCF as the top layer.…”

“…For this purpose, we applied several models to describe the respective release profiles according to909192. The authors of the present study have studied different materials and their release performances before589394959697. Unfortunately, as simple as our system may seem (schematically depicted in Fig.…”

“…Mostly NSAIDs are taken through systemic administration (i.e. in the form of pills), whereas several approaches have been and are being researched with regard to their integration into different formulations for local therapy58596061.…”

Evaluation of a two-stage antibacterial hydrogel dressing for healing in an infected diabetic wound

“…The core layer is made of fabric, which releases drug differentially at different pH values, with maximum release of drug in acidic medium. To decelerate the release rate, Maver et al proposed ultrathin cellulose supports as a platform for the incorporation of analgesic drugs in wound dressings. This dressing sustained the release of the entrapped drug and maintained the antibacterial activity up to 12 days .…”