Cellulose Fibrils Extracted from Bamboo Chips as a Reinforcing Material for Prolonged Drug Release

Abstract

Despite significant improvements in the intelligent delivery of drugs, the search for drug carriers with low cost and long‐term sustainable release still faces enormous challenges. In this study this issue was addressed for porous cellulose‐based aerogels by developing a Temperature/pH stimuli‐responsive carrier for drug controlled release. The prepared aerogels exhibited a smart 3D network with large specific surface area (112.6 m2 g−1) that facilitated the loading and transport of drug molecules. The aerogels were highly responsive to both temperature and pH in aqueous solution, which acted as a good switch for the molecular to control the release by adjusting the solution parameters. Moreover, the cell cytotoxicity and acute oral toxicity tests did not cause specific reactions and showed excellent biocompatibility. The simple manufacturing process, reversible drug release performance as well as the excellent biocompatibility make it a promising candidate for drug delivery.

Synthesis and Application of Cellulose-Polyethyleneimine Composites and Nanocomposites: A Concise Review

“…The release performances were studied in function of pH and temperature. The best conditions found for the release process were neutral pH and 37 • C temperature, perfectly fitting with the physiologic conditions of the human body [81].…”

Advancing biomedicine with gel‐based materials and composites: A comprehensive review

“…Whereas other routes of administration seem to be safe for the use of nanocellulose particles. For example, an oral acute toxicity study showed that when porous cellulose‐based aerogels were synthesized from bamboo pulp, no toxicity was found in mice with concentrations up to 6400 mg/kg after oral administration 154 …”