Células-tronco mesenquimais

Monteiro, Betânia Souza; Neto, Napoleão Martins Argôlo; Carlo, Ricardo Junqueira Del

doi:10.1590/s0103-84782010000100040

Cited by 40 publications

(43 citation statements)

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“…The observed bone growth interruption lines show abrupt discontinuation of osteoid matrix production and subsequent recovery, as described previously 13,27 . However, in this study, no local inflammatory infiltrate was observed, but only coarse and porous trabecular formation, without osteoblasts.…”

Section: ■ Discussionsupporting

confidence: 80%

“…It is evident that angiogenesis is evident in the trabecular bone, indicative of the acute phase of bone repair, with osteoid matrix structuring of immature braided osteophyte immediately adjacent to the blood vessels and massive infiltration of active osteoblasts, suggesting that they are responsible for matrix deposition. These characteristics suggest an intensification of the bone repair process, in the remodeling phase, since no inflammatory infiltrate was identified, as described previously 13,27 .…”

Section: ■ Discussionsupporting

confidence: 79%

“…The observed bone density varied between values below 1.375cm 3 and up to 1.465cm 3 , corresponding to the last and penultimate step of the penetrometer, respectively. Previous studies have described, in rabbits and mice, the predominant presence of fibrous connective tissue, associated with intense mixed inflammatory infiltration at the site of failure, in the first 30 days after bone failures in healthy or unhealthy patients 13,12 . These authors also used MSC and PRP as treatments for the analyzed bone failures, a fact that corroborates, with the densitometric findings of the present study, suggesting little local bone mineralization.…”

Section: ■ Discussionmentioning

confidence: 99%

“…Previous studies have already demonstrated the efficacy of MSC in the consolidation of fractures in healthy or non-healthy patients 11,13 .…”

mentioning

confidence: 99%

“…In addition to this alternative, autogenous platelet-rich plasma (PRP) has been used in contemporary studies with human and animal patients to stimulate bone repair 12,13 . This compound is rich in growth factors that stimulate mitogenesis, angiogenesis and increased activity of osteocompetent cells, determining rapid formation and bone homogeneity 13. It presents low yield, by volume, from the initial blood sample, which limits its use in small species 14 .…”

mentioning

confidence: 99%

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Allogeneic mesenchymal stem cells and xenogenic platelet rich plasma, associated or not, in the repair of bone failures in rabbits with secondary osteoporosis

et al. 2017

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Allogeneic mesenchymal stem cells and xenogenic platelet rich plasma, associated or not, in the repair of bone failures in rabbits with secondary osteoporosis¹ 9-Experimental SurgeryActa Cir Bras. 2017;32(9):767-780 AbstractPurpose: To assess the efficacy of allogeneic mesenchymal stem cells and xenogenic platelet rich plasma in the treatment of bone failure of osteoporotic rabbits secondary to estrogenic deprivation and iatrogenic hypercortisolism. Methods: Eight female rabbits underwent ovarian resection and corticoid therapy to induce clinical status of osteoporosis. Four failures were produced in the tibiae, with each failure being treated with hemostatic sponge, allogenic mesenchymal stem cells, xenogenic plateletrich plasma and the association between both. The animals were divided into two groups, evaluated radiographically and histopathologically at 30 and 60 days post treatment. Results: A radiographically confirmed consolidation of bone failures treated with allogeneic mesenchymal stem cells, associated with the histopathological image of mature and immature bone tissue, without evidence of osteopenia, was compared with the other groups, in which radiolucent failures with osteopenia and fibrosis were still present, denoting the satisfactory effect of the first treatment in detriment to the others. Conclusion:The treatment of bone failures of rabbits with secondary osteoporosis with allogeneic mesenchymal stem cells induced greater bone consolidation with mature and immature bone tissue production (p<0.01), when compared to the other treatments.

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Section: ■ Discussionsupporting

confidence: 80%

Section: ■ Discussionsupporting

confidence: 79%