Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886)

Abstract

Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.

Marine natural products

“…A diverse set of cembranoids, rearranged cembranoids and biscembranoids were reported from Lobophytum, Sinularia and Sarcophyton species of so corals in 2021. Lobophytum crassum was the source of lobocrassin I 1280 (Southern Taiwan) 555 while Ximao Island, South China Sea was the site of collection that led to the isolation of a further nine new cembranoids 1281-1289 and a set of known related metabolites including durumolide J 1290, lobolide A 1291, and 20-acetylsinularolide C 1292 and lobocrasol 1293. 556,557 XRD played a role in securing the absolute conguration of the new 1280 and known (durumolide J and lobolide A) cembranoids while that of 20-acetylsinularolide C was reassigned based upon Mosher's method of analysis.…”

Antitumor Cembrane Diterpenoids from the South China Sea Soft Coral Lobophytum sp.

“…Soft corals have been regarded as one of the most important marine source of bioactive compounds, especially various types of terpenoids, which made them attractive targets for natural product chemists. [1][2][3][4][5][6] Among them, those belonging to the genus Lobophytum have been shown to be a rich source of macrocyclic cembranoids [7][8][9] along with their cyclized [10 -13] and ring-opening [14,15] derivatives and dimers, [16,17] which were commonly described as defensive substances against predators such as fishes. [18,19] Importantly, some of these metabolites are of considerable interest and merit continuous attention due to their significant biological activities beyond unique structures, including anti-tumor, [20] anti-inflammatory, [21] anti-viral, [22] and antibacterial [23] properties.…”