Centaurea triumfetii essential oil chemical composition, comparative analysis, and antimicrobial activity of selected compounds

Carev, Ivana; Gelemanović, Andrea; Glumac, Mateo; Tutek, Klaudia; Dželalija, Mile; Paiardini, Alessandro; Prosseda, Gianni

doi:10.1038/s41598-023-34058-2

Cited by 13 publications

(3 citation statements)

References 52 publications

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“…It is believed that the antimicrobial activity of EOs is due to the chemical compounds that are the most abundant, without clear evidence for this. Carev et al [ 20 ] through in silico correlation analysis and experimental approaches investigated the relationship between the chemical constituents found in C. triumfettii essential oil and their antimicrobial activity in order to identify the potential active chemical components. After a literature review, the authors selected six chemical compounds (germacrene D, aromadendrene, spathulenol, longifolene, linoleic acid, and hexadecenoic acid), which have the highest content in the essential oil of C. triumfettii .…”

Section: Resultsmentioning

confidence: 99%

Bioactive Phyto-Compounds with Antimicrobial Effects and AI: Results of a Desk Research Study

Mihaylova,

Tsvetkova,

Georgieva

et al. 2024

Microorganisms

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Resistance of microorganisms to antibiotics represents a formidable global challenge, manifesting in intricate public health ramifications including escalated mortality rates and augmented healthcare costs. The current efforts to manage antimicrobial resistance (AMR) are limited mainly to the standard therapeutic approaches. The aim of this study is to present and analyze the role of artificial intelligence (AI) in the search for new phyto-compounds and novel interactions with antimicrobial effects. The ambition of the current research study is to support researchers by providing summarized information and ideas for future research in the battle with AMR. Inevitably, the AI role in healthcare is growing exponentially. The reviewed AI models reveal new data on essential oils (EOs) as potential therapeutic agents. In terms of antibacterial activity, EOs show activity against MDR bacteria, reduce resistance by sensitizing bacteria to the action of antibiotics, and improve therapeutic efficiency when combined with antibiotics. AI models can also serve for the detailed study of other therapeutic applications of EOs such as respiratory diseases, immune diseases, neurodegenerative diseases, and oncological diseases. The last 5 years have seen an increasing application of AI in the search for potential plant sources to control AMR. For the time being, the application of machine-learning (ML) models is greater in the studies of EOs. Future attention of research teams may also be directed toward a more efficient search for plant antimicrobial peptides (PAMPs). Of course, investments in this direction are a necessary preface, but the excitement of new possibilities should not override the role of human intelligence in directing research processes. In this report, tradition meets innovation to address the “silent pandemic” of AMR.

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Section: Resultsmentioning

confidence: 99%

Bioactive Phyto-Compounds with Antimicrobial Effects and AI: Results of a Desk Research Study

Mihaylova,

Tsvetkova,

Georgieva

et al. 2024

Microorganisms

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“…Nevertheless, despite the statistical correlations, it is necessary to test selected pure compounds in vitro and prove their activity, both as pure compounds and in mixtures, as the results might be surprising [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Profiling and Bioactivity Assessment of Helichrysum italicum (Roth) G. Don. Essential Oil: Exploring Pure Compounds and Synergistic Combinations

et al. 2023

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Helichrysum italicum (Roth) G. Don., immortelle, is a plant species used in ethnomedicine and the food industry as a spice added to food, beverages, and bakery products. It has been shown to possess various biological activities, such as antioxidant and antibacterial activity, making it useful as a natural preservative. We investigated the phytochemical profile and biological activity of H. italicum essential oils from wild-grown plant material collected from natural habitats in the Republic of Croatia and Bosnia and Herzegovina. Using high-resolution scanning electron microscopy (SEM), a visual investigation of plant organs (stem, leaf, and flower) was performed, confirming the presence of essential oil reservoirs on the surface of all examined plant organs. Essential oils were isolated by hydrodistillation in the Clevenger apparatus. The chemical composition of the essential oils was determined using the GC-MS analytical technique. Cytotoxic activity tests were performed in vitro on three cell lines: skin (fibroblast), lung, and breast cancer. Using statistical tools, the synergistic and selective effects of H. italicum essential oil on healthy and tumor cells were correlated to chemical composition and cytotoxic activity. The synergistic and antagonistic effects of H. italicum essential oil’s individual components were simulated by testing pure compounds and their mixture of cytotoxic activity on fibroblasts and breast cancer cells. The results confirm that essential oil’s biological activity is much greater than the sum of the effects of its components. The present data are novel contributions to the body of knowledge on the biological activity of this species used in the food industry.

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“…Centaurea essential oils are widely recognized for their medicinal effects. Essential oils including phytol, heptacosane, nonacosane and pentacosane exhibited a beneficial association with antibacterial activity, with excellent antimicrobial action against S. aureus and S. epidermidis, E. coli, B. cereus and K. pneumonia (Carev et al, 2023). Streptomyces sp.…”

Section: Discussionmentioning

confidence: 99%

Xenomyrothecium tongaense PTS8: a rare endophyte of Polianthes tuberosa with salient antagonism against multidrug-resistant pathogens

Sundar,

Arunachalam

2024

Front. Microbiol.

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IntroductionEndophytes refer to microorganisms residing within the endosphere of plants, particularly perennials, without inflicting noticeable injury or inducing obvious morphological variations to their host plant or host organism. Endophytic fungi, although often overlooked microorganisms, have garnered interest due to their significant biological diversity and ability to produce novel pharmacological substances.MethodsIn this study, fourteen endophytic fungi retrieved were from the stem of the perennial plant Polianthes tuberosa of the Asparagaceae family. These fungal crude metabolites were tested for antagonistic susceptibility to Multi-Drug Resistant (MDR) pathogens using agar well diffusion, Minimum Inhibitory Concentration (MIC), and Minimum Bactericidal Concentration (MBC) assays. The chequerboard test was used to assess the synergistic impact of active extract.Results and discussionIn early antibacterial screening using the Agar plug diffusion test, three of fourteen endophytes demonstrated antagonism against Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Enterococcus (VRE). Three isolates were grown in liquid medium and their secondary metabolites were recovered using various organic solvents. Eight extracts from three endophytic fungi displayed antagonism against one or more human pathogens with diameters ranging from 11 to 24 mm. The highest antagonistic effect was obtained in ethyl acetate extract for PTS8 isolate against two MRSA (ATCC 43300, 700699) with 20 ± 0.27 and 22 ± 0.47 mm zones of inhibition, respectively, among different solvent extracts. The extract had MICs of 3.12 ± 0.05 and 1.56 ± 0.05 μg/mL, and MBCs of 50 ± 0.01 and 12.5 ± 0.04 μg/mL, respectively. Antagonism against VRE was 18 ± 0.23 mm Zone of Inhibition (ZOI) with MIC and MBC of 6.25 ± 0.25 and 25 ± 0.01 μg/mL. When ethyl acetate extract was coupled with antibiotics, the chequerboard assay demonstrated a synergistic impact against MDR bacteria. In an antioxidant test, it had an inhibitory impact of 87 ± 0.5% and 88.5 ± 0.5% in 2,2-Diphenyl-1-Picrylhydrazyl and reducing power assay, respectively, at 150 μg/mL concentration. PTS8 was identified as a Xenomyrothecium tongaense strain by 18S rRNA internal transcribed spacer (ITS) sequencing. To our insight, it is the foremost study to demonstrate the presence of an X. tongaense endophyte in the stem of P. tuberosa and the first report to study the antibacterial efficacy of X. tongaense which might serve as a powerful antibacterial source against antibiotic-resistant human infections.

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Centaurea triumfetii essential oil chemical composition, comparative analysis, and antimicrobial activity of selected compounds

Cited by 13 publications

References 52 publications

Bioactive Phyto-Compounds with Antimicrobial Effects and AI: Results of a Desk Research Study

Bioactive Phyto-Compounds with Antimicrobial Effects and AI: Results of a Desk Research Study

Chemical Profiling and Bioactivity Assessment of Helichrysum italicum (Roth) G. Don. Essential Oil: Exploring Pure Compounds and Synergistic Combinations

Xenomyrothecium tongaense PTS8: a rare endophyte of Polianthes tuberosa with salient antagonism against multidrug-resistant pathogens

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