In this paper we study the center problem for certain generalized Kukles systemṡ x = y,ẏ = P 0 (x) + P 1 (x)y + P 2 (x)y 2 + P 3 (x)y 3 , where P i (x) are polynomials of degree n, P 0 (0) = 0 and P 0 (0) < 0. Computing the focal values and using modular arithmetics and Gröbner bases we find the center conditions for such systems when P 0 is of degree 2 and P i for i = 1, 2, 3 are of degree 3 without constant terms. We also establish a conjecture about the center conditions for such systems.