Central Adrenoceptors and Cholinoceptors in Cardiovascular Control

Bhargava, K. P.; Jain, Lovesh; Saxena, Anil Kumar; Sinha, J. N.; Tangri, K.K.

doi:10.1111/j.1476-5381.1978.tb07768.x

Cited by 49 publications

(13 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been shown that catecholamines can influence cholinergic transmission [7,12,27], It can be supposed that the adrenergic nervous system participates in the develop ment of hypertension [14,30,36]. It appears from our results that the cholinergic nervous system is also influenced during development of hypertension.…”

Section: Discussionsupporting

confidence: 64%

See 1 more Smart Citation

Development of Cholinergic Nervous System in the Brain of Normal and Hypertensive Rats

Bajgar¹,

Hrdina²,

Petr³

et al. 1979

Dev Neurosci

View full text Add to dashboard Cite

Triton X-100 extracted brain AChE and ChAc molecular forms of normal and hypertensive rats were studied during pre- and postnatal development. AChE of the brain could be separated into 4, ChAc into 3 molecular forms. Activities of both AChE and ChAc forms were increased with age. In hypertension some molecular forms of AChE and ChAc were much more affected than others. These findings suggest that different molecular forms of each enzyme may have different physiological roles.

show abstract

Section: Discussionsupporting

confidence: 64%

“…This is in agreement with results of Bliargava el al. [7] on the relationship between cholinergic and adrenergic mecha nisms in cardiovascular control. The changes of ChAc and AChE were statistically signifi cant from 20th to 30th days after birth.…”

Section: Discussionmentioning

confidence: 99%

Development of Cholinergic Nervous System in the Brain of Normal and Hypertensive Rats

Bajgar¹,

Hrdina²,

Petr³

et al. 1979

Dev Neurosci

View full text Add to dashboard Cite

show abstract

“…a-Adrenoreceptors and glycine receptors appear to mediate inhibition of thoracico-lumbar preganglionic sympathetic neurones (Haeusler, 1976) while padrenoreceptors at this level may facilitate tachycardia and hypertension (Bhargava et al, 1978).…”

Section: Control Of Blood Pressure At the Spinal Levelmentioning

confidence: 99%

The central noradrenergic control of blood pressure and heart rate

Elliott

1979

Clin Exp Pharmacol Physiol

View full text Add to dashboard Cite

Investigation of the postulated central hypotensive actions of clonidine, methyldopa and P-adrenoreceptor blocking drugs has prompted intensive research into the neurophysiological basis of central cardiovascular control. Species differences and the general lack of specificity of the pharmacological tools available complicate such investigations. Although many studies implicate noradrenaline as a transmitter in central cardiovascular control, there have been conflicting reports regarding the role(s) of this putative neurotransmitter. The postulated roles of brain amines in experimental hypertension have been reviewed by Chalmers (1975).In this review evidence for the noradrenergic control of blood pressure and heart rate in the spinal cord, at the level of the medulla and from within the hypothalamus is discussed in the light of recent attempts to characterise central adrenoreceptors.Early electrical brain stimulation studies showed the most important areas able to modify cardiovascular function are located in the brain stem and hypothalamus (reviews by Korner, 1971 ;Smith, 1974). The area of the nucleus tractus solitarius in the medulla was found to be the site of one of the primary relays of the baroreceptor or carotid sinus afferent fibres (Crill & Reis, 1968). Baroreceptor activity has been found to project via polysynaptic pathways as far as the hypothalamus; furthermore, electrical stimulation of the hypothalamus has been shown to modify baroreceptor reflexes.The histochemical fluorescence technique developed by Falck et al.(1 962) and the more sensitive glyoxylic acid fluorescence method used by Lindvall & Bjorklund (1974) subsequently revealed a dense noradrenergic innervation of nuclei within the brain stem, spinal cord and hypothalamus. These nuclei include the intermedio-lateral nucleus of the spinal cord, the nucleus tractus solitarius, dorsal vagal nucleus, nucleus reticularis lateralis and locus coeruleus of the medulla, and nuclei of both the posterior and anterior hypothalamus. From the beginning of this decade therefore, it has been general opinion that the distribution of noradrenaline containing nerve endings in the mid brain and hind brain strongly suggests a transmitter role of noradrenaline in modulating central cardiovascular control (Bolme, Fuxe & Lidbrink, 1972). Control of blood pressure at the spinal levelA high density of noradrenalinecontaining neurones has been demonstrated in the intermedio-lateral columns where they appear to make intimate synaptic contact with sympathetic preganglionic neurones. a-Adrenoreceptors and glycine receptors appear to mediate inhibition of thoracico-lumbar preganglionic sympathetic neurones (Haeusler, 1976) while padrenoreceptors at this level may facilitate tachycardia and hypertension (Bhargava et al., 1978).

show abstract

“…Furthermore, superfusion of nicotine at the medullary levels produced both pressor and depressor effects in cats (3). The purpose of the present study was to examine the possible involvement of central nicotinic mechanisms in the main tenance of hypertension in SHR by testing the effect of intraventricular nicotine admin istration on blood pressure in this strain of rats.…”

mentioning

confidence: 99%

“…Brain acetylcholine has been implicated in the central control of cardiovascular function (1)(2)(3)(4). However, little information is available concerning the possible involve ment of central cholinergic mechanisms in the pathophysiology of arterial hypertension.…”

mentioning

confidence: 99%

Increased pressor responses to nicotine in spontaneously hypertensive rats.

Kubo

Misu

1981

Jpn.J.Pharmacol

View full text Add to dashboard Cite

Abstract-Intraventricular administration of nicotine produced a biphasic effect, consisting of an initial rise then a slight fall in blood pressure in unanaesthetized rats. Spontaneously hypertensive rats (SHR) showed increased pressor responses, but these responses were within normal limits in renal hypertensive and DOCA-saline hypertensive rats. The blood pressure response to nicotine in SHR was abolished by intraventricular administration of hexamethonium, but not by atropine given via the same route. Central phentolamine and 6-hydroxydopamine did not affect the pressor response to nicotine. The pressor effect of nicotine in SHR was markedly diminished after removal of the adrenals and abolished after bilateral adrenalectomy plus peripheral 6-hydroxydopamine. These results indicate that the pressor response to intraventricular nicotine is increased in SHR. The pressor effect of nicotine may result from the activation of the central nicotinic receptor sites, which may cause the release of catechol amines both from the adrenal medulla and adrenergic nerve terminals.

show abstract

Central Adrenoceptors and Cholinoceptors in Cardiovascular Control

Cited by 49 publications

References 30 publications

Development of Cholinergic Nervous System in the Brain of Normal and Hypertensive Rats

Development of Cholinergic Nervous System in the Brain of Normal and Hypertensive Rats

The central noradrenergic control of blood pressure and heart rate

Increased pressor responses to nicotine in spontaneously hypertensive rats.

Contact Info

Product

Resources

About