Central and peripheral fat body mass have a protective effect on osteopenia or osteoporosis in adults and elderly?

Freitas, Patrícia Martins de; Rosa, Maria Luiza Garcia; Gomes, Ana Maria; Wahrlich, Vivian; Luca, Daniel G. Di; Filho, Rubens Antunes da Cruz; Correia, Dayse Mary da Silva; Faria, Carlos Augusto; Yokoo, Edna Massae

doi:10.1007/s00198-015-3414-5

Cited by 18 publications

(13 citation statements)

References 12 publications

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“…Inconsistent with that, several studies stated AFM had no24 or a negative25 relationship with BMD. Freitas et al 26 showed that central fat was positively associated with BMD and regarded as an independent and protective factor for the presence of osteoporosis or osteopenia. Sharma et al 27 reported that a bigger trunk (central) FM was associated with increased BMD in the total hip and femoral neck, regardless of HIV status in women.…”

Section: Discussionmentioning

confidence: 99%

Sex-specific and age-specific characteristics of body composition and its effect on bone mineral density in adults in southern China: a cross-sectional study

et al. 2020

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ObjectivesThis study was an attempt to investigate the variation trend of body composition with ageing and explore the association between regional body composition and bone mineral density (BMD).DesignCross-sectional study.Setting and participantsA total of 5749 healthy adults aged 20–95 years was recruited from 2004 to 2017.Primary outcome measuresWhole-body lean mass (LM), fat mass (FM), android FM, gynoid FM, appendicular lean mass (ALM) and BMD in the lumbar spine, femoral neck and total hip were obtained by dual-energy X-ray absorptiometry (DXA). The android/gynoid fat mass ratio (A/G FMR) based on DXA scan was calculated as an indicator of adipose distribution. Pearson correlation and multiple linear regression analyses were used to determine the associations between body composition, adipose distribution, and BMD of each skeletal site.ResultsWhole-body FM, percentage of whole-body FM, Android FM and A/G FMR consistently increased with age in both genders, especially in women, and ALM began to decrease in the fifth decade for both men and women. In multivariable linear regression models with age, body mass index, A/G FMR and ALM as predictor variables, ALM was associated with the most BMD variance of all skeletal sites in men (standard β ranged from 0.207 to 0.405, p<0.001), although not the largest but still a positive predictor of BMD in women (standard β ranged from 0.074 to 0.186, p<0.05). A/G FMR was an inverse predictor of BMD at all skeletal sites for women (standard β ranged from −249 to −0.052, p<0.01) but not in men.ConclusionsIn this large cohort of Chinese adults, ALM had a strong positive association with BMD in both genders. A/G FMR as an indicator of central adipose accumulation was inversely associated with BMD in women but not in men.

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Section: Discussionmentioning

confidence: 99%

Sex-specific and age-specific characteristics of body composition and its effect on bone mineral density in adults in southern China: a cross-sectional study

et al. 2020

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“…Additionally, there exist studies that have shown that weight and high BMI are positively associated with BMD, while other studies have shown that body fat percentage influences BMD negatively [28]. Central or peripheral body fat mass have been reported to be inversely associated with BMD [29]. Visceral fat has also been reported to have negative impact on trabecular bone mass [30].…”

Section: Discussionmentioning

confidence: 99%

Screening post-menopausal women for bone mineral level by bioelectrical impedance spectroscopy of dominant arm

Öztürk

Öztürk-Işık

Ülgen

2018

Journal of Electrical Bioimpedance

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Dominant arm bioimpedance spectroscopy (BIS) and lumbar and hip dual energy X-ray absorptiometry (DXA) measurements were conducted simultaneously on 48 post-menopausal women, aged between 43 and 86 years, with no hip or arm fracture history at Department of Radiology of Istanbul University Cerrahpasa Hospital. According to lumbar DXA results, 21 women were classified as normal, 22 as osteopenia and 5 as osteoporosis; whereas hip DXA results classified 30 women as normal, 15 as osteopenia and 3 as osteoporosis. Only 26 participants had identical lumbar and hip bone mineral density (BMD) diagnostic results. Dominant arm characteristic frequencies of normal subjects were statistically significantly different from osteoporotic subjects based on both lumbar (p < 0.005) and hip classification groups (p < 0.001). Hip and lumbar spine DXA BMD values were significantly correlated (r = 0.55, p < 0.005). The dominant arm BIS characteristic frequency, considered as the single predictor in earlier diagnosis of osteoporosis, was found negatively correlated with DXA measurements for both hip and lumbar spine regions. The Spearman rank correlation coefficient of BIS values with the hip DXA values (r = -0.53, p < 0.001) was higher than that of lumbar spine (r = -0.37, p < 0.001). In receiver operating characteristic (ROC) curve analysis, the best discrimination of dominant arm characteristic frequency was made between normal and osteoporotic subjects based on the hip subgroups (p < 0.001). Both lumbar bone mineral content (BMC) (r = -0.47, p < 0.001) and hip BMC (r = -0.4340, p < 0.005) were statistically significantly correlated with dominant arm characteristic frequency.

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“…31 However, the relation of obesity with osteoporosis has been questioned and several studies have supported an aggravating role of obesity in osteoporosis. [32][33][34][35] Unfortunately, neither DEXA nor BIA-ACC ® could estimate obesity-related qualitative changes of the muscle and bone architecture.…”

Section: Discussionmentioning

confidence: 99%

Bioimpedance analysis vs. DEXA as a screening tool for osteosarcopenia in lean, overweight and obese Caucasian postmenopausal females

Peppa

Stefanaki

Papaefstathiou

et al. 2017

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Central and peripheral fat body mass have a protective effect on osteopenia or osteoporosis in adults and elderly?

Abstract: Since both obesity and osteoporosis are public health problems worldwide, strategies aimed at preventing both conditions should be encouraged during aging.

Cited by 18 publications

References 12 publications

Sex-specific and age-specific characteristics of body composition and its effect on bone mineral density in adults in southern China: a cross-sectional study

Sex-specific and age-specific characteristics of body composition and its effect on bone mineral density in adults in southern China: a cross-sectional study

Screening post-menopausal women for bone mineral level by bioelectrical impedance spectroscopy of dominant arm

Bioimpedance analysis vs. DEXA as a screening tool for osteosarcopenia in lean, overweight and obese Caucasian postmenopausal females

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