Central Diabetes Insipidus in Infancy With or Without Hypothalamic Adipsic Hypernatremia Syndrome: Early Identification and Outcome

Djermane, Adel; Elmaleh, Monique; Simon, Dominique; Poidvin, Amélie; Carel, Jean‐Claude; Léger, Juliane

doi:10.1210/jc.2015-3108

Cited by 34 publications

(22 citation statements)

References 38 publications

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“…Существуют ограниченные исследования, связанные с лечением неонатального центрального несахарного диабета деспопрессином, но в целом этот препарат рекомендуется применять с осторожностью из-за высокой вероятности сильных скачков уровня сывороточного натрия [8]. Для коррекции повышенного уровня натрия в крови и гипертермии была рассчитана суточная потребность ребенка в жидкости.…”

Section: Discussionunclassified

“…There were limited resources to do the antidiuretic hormone level and genetic mutation but the history of natal and postnatal course of the baby was suggestive of central diabetes insipidus. There are limited studies related the treatment of neonatal central DI by desmopressin but generally it is not recommended as initial management but the last choice as there is high probability of wide swings in serum sodium (8) The fluid requirement per 24 hours was calculated and it was given to the baby as bottle milk feeds and plain water which successfully controlled the hypernatremia.…”

Section: Discussionmentioning

confidence: 99%

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Neonatal Diabetes Insipidus in a Palestinian Newborn

Абухамда

2019

Ross. vestn. perinatol. pediatr.

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Diabetes insipidus is rare in newborn. There are two types of this disease: central and nephrogenic diabetes insipidus. A Palestinian infant was born at Shifa Women`s Hospital at full term by urgent cesarean section. At the age of 13 days he had fever, hypernatremia, polyuria, weight loss and low specific gravity of urine. The baby was diagnosed to have diabetes insipidus. The baby was successfully treated by fluid loss recovery by bottle feeding and intravenous 5% dextrose and sodium chloride solution. At home, they continued to correct fluid loss by bottle- feeding and drinking water.

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Section: Discussionunclassified

Section: Discussionmentioning

confidence: 99%

Neonatal Diabetes Insipidus in a Palestinian Newborn

Абухамда

2019

Ross. vestn. perinatol. pediatr.

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“…More clarity in managing hydrocephalus associated with aHPE is always a goal, and this case leads us to investigate the effects of shunting on the hypothalamic osmoreceptor function, which may contribute to adipsic central diabetes insipidus [6]. …”

Section: Discussionmentioning

confidence: 99%

Management Strategies for Hydrocephalus in Alobar Holoprosencephaly: A Case Report and Discussion

et al. 2018

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Holoprosencephaly is a rare congenital malformation resulting from an impaired midline division of the prosencephalon into distinct cerebral hemispheres. Hydrocephalus is a frequent problem among the few survivors with alobar holoprosencephaly (aHPE), its most severe form. The literature about neurosurgical management of hydrocephalus in this condition is limited and dispersed, and there are still some points that need to be resolved. We report the case of a newborn with aHPE, hydrocephalus, and central diabetes insipidus. We delineate the complexity of the management of these patients and emphasize the benefits of using an initial programmable shunt valve. Further discussion about management strategies includes reviewing previous reports and the benefits of shunting for hypothalamic osmoreceptor function.

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“…Although MRI finding of an absent posterior pituitary hyperintense signal is not diagnostic, it is awell-known characteristic of CDI[11][12][13] . Ectopic posterior pituitary was observed in three neonates in a study reported by Djermane et al8) . An ectopic posterior pituitary may be the cause of CDI due to a structural anomaly in the current patient.…”

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confidence: 81%

“…Idiopathic CDI is thought to account for 12% to 24% of cases 2) . Previous reports of CDI in preterm infants [2][3][4][5][6][7][8][9] , excluding traumatic or ischemic brain injuries, are summarized in Table 1.…”

Section: Case Reportmentioning

confidence: 99%

Central Diabetes Insipidus in an Extremely-Low-Birth-Weight Preterm Infant with Suspected Ectopic Posterior Lobe of the Pituitary Gland

Park¹,

Hwang²,

Kim³

et al. 2020

Neonatal Med

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Central diabetes insipidus (CDI) is extremely rare in neonates, especially in extremelylow-birth-weight infants, and most cases are secondary to conditions, such as ischemic or hemorrhagic brain damage. Here, we report a case of CDI in a 530-g infant born at 23 +3 weeks of gestation, with suspected ectopic posterior pituitary gland. Hypernatremia was noticed at 33 +6 weeks of postmenstrual age, and it persisted with in creased volumes of diluted urine, despite adequate sodium intake. Serum and urine osmolality returned to the normal range after administration of a desmopressin injection. The bright spot of the posterior pituitary was absent, and brain magnetic resonance imaging suggested an ectopic posterior pituitary gland. At the time of writing this manuscript, the patient was on oral desmopressin medication without complications at the corrected age of 8 months. Through this report, we emphasize that although CDI is extremely rare in premature infants, it should be suspected when hypernatremia and polyuria that are unexplained by other causes are noted.

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Central Diabetes Insipidus in Infancy With or Without Hypothalamic Adipsic Hypernatremia Syndrome: Early Identification and Outcome

Abstract: Neonatal CDI may be transient or permanent. These vulnerable patients have high rates of comorbidity and require careful monitoring.

Cited by 34 publications

References 38 publications

Neonatal Diabetes Insipidus in a Palestinian Newborn

Neonatal Diabetes Insipidus in a Palestinian Newborn

Management Strategies for Hydrocephalus in Alobar Holoprosencephaly: A Case Report and Discussion

Central Diabetes Insipidus in an Extremely-Low-Birth-Weight Preterm Infant with Suspected Ectopic Posterior Lobe of the Pituitary Gland

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