Central fatigue in multiple sclerosis: a review of the literature

Newland, Pamela; Starkweather, Angela; Sorenson, Matthew

doi:10.1080/10790268.2016.1168587

Cited by 62 publications

(46 citation statements)

References 63 publications

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“…The researchers believes that fatigue severity in MS was increases in those who were older and had a longer time, since symptom onset occur and could be effect on; cognitive, motor functioning, social activity or relationships, therefore early symptoms management in MS is a key strategy to effective self management. This finding in line with [6,35] who noted that fatigue in MS after (15)(16)(17)(18)(19)(20) years of symptom onset, can lead to progressive course or clinical deterioration of MS. [52] added that fatigue in MS patients is associated with reduced employment and lower quality of life over time. In addition [6] explained that early management of fatigue in MS can help in starting a suitable treatment and prevent complication.…”

Section: Discussionsupporting

confidence: 85%

Fatigue and Self-management among Multiple Sclerosis Patients

Shawli¹,

Abdulmutalib²,

Nagshabandi³

2019

AJNR

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Fatigue is considered as the most revealed symptoms in multiple sclerosis patients, reported by 88% of patients and has significant impact on all stages of life such as altering in daily living activity or psychosocial/mental functions. The pathogenesis of fatigue remain poorly understood and how its impact on self-management. The aim of study was to assess fatigue and self management among multiple sclerosis patients. A quantitative descriptive correlational design was used in this study. The study was conducted at both King Abdulaziz University Hospital and King Fahad Armed Forces Hospitals in Jeddah City from January till March 2018, data collected from outpatients' clinic and Inpatients' medical-wards. A convenience sample of 50 Multiple Sclerosis patients. Data was collected through the main one tool, it consists of three parts; Part I, Socio-demographic and clinical data constructed by the researchers. Part П, Modified Fatigue Impact scale; to assess the Impact of fatigue on physical, cognitive, and psychosocial functioning in patient with Multiple Sclerosis.. Part ПІ, Multiple Sclerosis Self Management Scale Revised; to provide a multidimensional and psychometrically assessment of self-management knowledge and behavior among Multiple Sclerosis patients. The study results showed there was a statistically significant negative correlations between fatigue subscales and overall self-management among Multiple Sclerosis patients with p-value (.019). Also, there was a statistically significant negative correlations between self-management factor scales and overall fatigue among Multiple Sclerosis patients with p-value (.019). It was concluded that there was a negative correlations between overall fatigue and overall self-management among Multiple Sclerosis patients, whenever fatigue severity increases, self-management decreases. It was a recommendation to encourage governmental policy and other decision makers in the Saudi community to develop periodically structure health education training program regarding self-management in MS and provide appropriate environments or facilities to conduct such programs, where nurses play a key role through health education and cooperate with other health care system.

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Section: Discussionsupporting

confidence: 85%

Fatigue and Self-management among Multiple Sclerosis Patients

Shawli¹,

Abdulmutalib²,

Nagshabandi³

2019

AJNR

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“…Fatigue was known as a debilitating symptom, which was frequently reported among MS patients 32, 33. Little is understood about the mechanisms and determinants of fatigue 34. Axonal damage as measured by N‐acetylaspartate‐creatinine ratio on proton magnetic resonance spectroscopy scanning have been associated with fatigue in MS patients 35.…”

Section: Discussionmentioning

confidence: 99%

“…32,33 Little is understood about the mechanisms and determinants of fatigue. 34 Axonal damage as measured by N-acetylaspartate-creatinine ratio on proton magnetic resonance spectroscopy scanning have been associated with fatigue in MS patients. 35 Our results supported these findings, and may provide serum NfL as a potential biomarker and predictor of fatigue, which may be utilized in clinical monitoring or for clinical trials.…”

Section: Discussionmentioning

confidence: 99%

Neurofilament light chain serum levels correlate with 10‐year MRI outcomes in multiple sclerosis

Chitnis

Gonzalez

Healy

et al. 2018

Ann Clin Transl Neurol

127

141

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ObjectiveTo assess the value of annual serum neurofilament light (NfL) measures in predicting 10‐year clinical and MRI outcomes in multiple sclerosis (MS).MethodsWe identified patients in our center's Comprehensive Longitudinal Investigations in MS at Brigham and Women's Hospital (CLIMB) study enrolled within 5 years of disease onset, and with annual blood samples up to 10 years (n = 122). Serum NfL was measured using a single molecule array (SIMOA) assay. An automated pipeline quantified brain T2 hyperintense lesion volume (T2LV) and brain parenchymal fraction (BPF) from year 10 high‐resolution 3T MRI scans. Correlations between averaged annual NfL and 10‐year clinical/MRI outcomes were assessed using Spearman's correlation, univariate, and multivariate linear regression models.ResultsAveraged annual NfL values were negatively associated with year 10 BPF, which included averaged year 1–5 NfL values (unadjusted P < 0.01; adjusted analysis P < 0.01), and averaged values through year 10. Linear regression analyses of averaged annual NfL values showed multiple associations with T2LV, specifically averaged year 1–5 NfL (unadjusted P < 0.01; adjusted analysis P < 0.01). Approximately 15–20% of the BPF variance and T2LV could be predicted from early averaged annual NfL levels. Also, averaged annual NfL levels with fatigue score worsening between years 1 and 10 showed statistically significant associations. However, averaged NfL measurements were not associated with year 10 EDSS, SDMT or T25FW in this cohort.InterpretationSerum NfL measured during the first few years after the clinical onset of MS contributed to the prediction of 10‐year MRI brain lesion load and atrophy.

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“…An accelerating rotarod test revealed that UNC5B cKOs were able to learn the task to a level equal to controls, but intriguingly, aged animals exhibited a deficit in the rate of acquisition to learn the motor skill. The delay in motor learning may result from increased fatigue, as myelin disruption can increase fatigue (Simpson et al, 2016), and fatigue is a prominent symptom in demyelinating diseases like multiple sclerosis (Freal et al, 1984;Krupp et al, 1988;Newland et al, 2016); however, UNC5B deletion may also disrupt some aspect of myelin plasticity, which is increasingly understood to play roles in learning, including motor learning (Chorghay et al, 2018;de Faria et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Paranode stability requires UNC5B expression by oligodendrocytes

Faria

Nakamura

Clemot

et al. 2020

Preprint

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Netrins are secreted proteins that direct cell migration and axon extension in the developing CNS and are essential for normal neural development. In the mature CNS, netrin-1 is expressed by neurons and oligodendrocytes and implicated in the stability of axo-oligodendroglial paranodal junctions. Here we report that the netrin receptor UNC5B is highly expressed by mature oligodendrocytes and enriched at paranodes. We demonstrate that paranodes become disorganized following conditional deletion of UNC5B in oligodendrocytes, with disruption of the interface between glial loops and detachment of glial loops from the axon. Examining axoglial domain segregation, Caspr1 and Kv1.1 disperse along the axon, internodes shorten, and the periodicity of compact myelin is reduced, indicating significant breakdown of myelin organization in UNC5B cKOs. Paranodal disruption and axoglial domain disorganization progressively worsen with age and a delay in motor learning develops specifically in aged animals that lack oligodendroglial UNC5B. We detect reduced amounts of oligodendroglial Claudin-11 and JAM-C proteins in UNC5B knockouts, suggesting that disruption of the specialized autotypic junctions between glial loops may underlie paranodal disorganization. Our findings reveal an essential contribution of oligodendroglial UNC5B at axoglial junctions that is required for the stability of mature myelin.

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Central fatigue in multiple sclerosis: a review of the literature

Abstract: Future research on MS-related fatigue may consider a longitudinal design with a carefully selected self-report instrument to advance understanding of the underlying pathological mechanisms.

Cited by 62 publications

References 63 publications

Fatigue and Self-management among Multiple Sclerosis Patients

Fatigue and Self-management among Multiple Sclerosis Patients

Neurofilament light chain serum levels correlate with 10‐year MRI outcomes in multiple sclerosis

Paranode stability requires UNC5B expression by oligodendrocytes

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