Central ghrelin treatment stimulates ACTH cells in normal-fed, food-restricted and high-fed rats: An immunohistomorphometric and hormonal study

Milošević, Verica; Ajdžanović, Vladimir; Nešić, Dejan; Starčević, Vesna; Filipović, Branko; Rakocevic, Rastko; Stevanović, Darko

doi:10.1016/j.acthis.2013.04.003

Cited by 3 publications

(2 citation statements)

References 52 publications

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Section: Observations)mentioning

confidence: 99%

“…Native AG , Tassone et al 2003, Vestergaard et al 2007, Milosevic et al 2013 or the synthetic GHSs (Korbonits et al 1995, Bowers & Granda-Ayala 1996, Arvat et al 1997, Clark et al 1997 have been shown to stimulate ACTH secretion in several species, such as humans and rats. However, this effect could depend on the metabolic/ energy status, as AG-induced ACTH secretion has been shown to be impaired in obesity (Milosevic et al 2013). Interestingly, recent studies have suggested that AG could be controlling ACTH release by acting at several levels, in that AG can act directly at the pituitary level by increasing free cytosolic calcium levels (Yamazaki et al 2012) and also at the hypothalamic level by stimulating corticotrophinreleasing hormone (CRH) and arginine-vasopressin (AVP) production in rats (Wren et al 2002).…”

Section: Observations)mentioning

confidence: 99%

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Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Gahete

Rincón-Fernández

Villa-Osaba

et al. 2013

Journal of Endocrinology

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Ghrelin is a 28-amino acid acylated hormone, highly expressed in the stomach, which binds to its cognate receptor (GHSR1a) to regulate a plethora of relevant biological processes, including food intake, energy balance, hormonal secretions, learning, inflammation, etc. However, ghrelin is, in fact, the most notorious component of a complex, intricate regulatory system comprised of a growing number of alternative peptides (e.g. obestatin, unacylated ghrelin, and In1-ghrelin, etc.), known (GHSRs) and, necessarily unknown receptors, as well as modifying enzymes (e.g. ghrelin-O-acyl-transferase), which interact among them as well as with other regulatory systems in order to tightly modulate key (patho)-physiological processes. This multiplicity of functions and versatility of the ghrelin system arise from a dual, genetic and functional, complexity. Importantly, a growing body of evidence suggests that dysregulation in some of the components of the ghrelin system can lead to or influence the development and/or progression of highly concerning pathologies such as endocrine-related tumors, inflammatory/cardiovascular diseases, and neurodegeneration, wherein these altered components could be used as diagnostic, prognostic, or therapeutic targets. In this context, the aim of this review is to integrate and comprehensively analyze the multiple components and functions of the ghrelin system described to date in order to define and understand its biological and (patho)-physiological significance.

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Section: Observations)mentioning

confidence: 99%

Section: Observations)mentioning

confidence: 99%

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Gahete

Rincón-Fernández

Villa-Osaba

et al. 2013

Journal of Endocrinology

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Restrictive Eating Disorders and Skeletal Health in Adolescent Girls and Young Women

Thornton

Gordon

2016

Calcif Tissue Int

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This article reviews the effects of restrictive eating disorders on bone health. The relationship between eating disorders and amenorrhea is discussed in detail. The pathologic impact of malnutrition on bone is explored by examining the results of studies using various available imaging techniques. The multiple hormonal alterations seen in adolescents and young women with anorexia nervosa are reviewed, as well as how these alterations may influence bone turnover, density, structure, and strength. The diagnostic clinical evaluation for adolescents and young women with these disorders is also outlined. Available treatment options, including those that hold promise for efficacy, as well as those we deemed to be ineffective, are considered from both the clinical and mechanistic standpoints. Finally, future research opportunities are offered, including intriguing work in the area of fat and bone interactions.

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Ghrelin and GHS-R in the rat gastric mucosa: Are they involved in regulation of growth during early weaning?

et al. 2016

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Central ghrelin treatment stimulates ACTH cells in normal-fed, food-restricted and high-fed rats: An immunohistomorphometric and hormonal study

Cited by 3 publications

References 52 publications

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Restrictive Eating Disorders and Skeletal Health in Adolescent Girls and Young Women

Ghrelin and GHS-R in the rat gastric mucosa: Are they involved in regulation of growth during early weaning?

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