Central low-grade osteosarcoma: a diagnostic challenge

Bonar, S. Fiona

doi:10.1007/s00256-012-1359-8

Cited by 13 publications

(13 citation statements)

References 14 publications

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“…In addition, LGCOS has the potential to dedifferentiate [ 7 – 9 ]; four of our cases contained components with high-grade histology at the time of recurrence. As expected, DLGOS had a worse prognosis than LGOS due to the increased risk of metastasis, which is also confirmed in the literature [ 1 , 6 , 10 , 31 ].…”

Section: Discussionsupporting

confidence: 87%

“…However, LGOS has the potential to dedifferentiate to high-grade malignant lesions (DLGOS) upon recurrence [ 5 – 9 ]. Some LGOS will also show areas of high-grade malignancy already at primary diagnosis [ 1 , 10 ]. Adjuvant chemotherapy is recommended in such circumstances [ 1 , 8 ], due to the increased risk of subsequent metastasis [ 1 , 8 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009

Berner

Johannesen

Bruland

2015

Sarcoma

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Purpose. To describe epidemiological, clinical characteristics and treatment outcomes of low-grade osteosarcoma (LGOS), including dedifferentiated osteosarcoma (DLGOS). Method. We analysed a nationwide cohort comprised of patients with histologically verified LGOS and DLGOS between 1975 and 2009, based on registry sources supplemented with clinical records from hospitals involved in sarcoma management. Results. Fifty-four patients were identified, 12 of whom had DLGOS. The annual incidence for all patients was 0.3 per million, with the peak incidence in the third decade of the life. Fifteen patients experienced local relapses during follow-up and ten developed metastatic diseases, including three at primary diagnosis. Patients with DLGOS dominated the metastatic relapse group. The five-year sarcoma-specific survival rate was 91%, with no documented improvement over time. Free margin following surgical resection of the primary tumour had a positive impact on survival. As expected, both local relapse and metastasis during follow-up were associated with an unfavourable outcome. Radiotherapy predicted poor survival due to the selection of high-risk patients in need of such treatment. Neither higher age nor axial tumour localisation was adverse prognostic factors. Conclusion. LGOS has an excellent prognosis when surgically resected with a free margin; however, LGOS has the potential to dedifferentiate and metastasize with a poor outcome.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009

Berner

Johannesen

Bruland

2015

Sarcoma

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“…They usually comprise a bland fibro-osseous lesion composed of spindle cells in a fibrous stroma with a variable osseous component and mild cellular atypia at most. Mitoses are usually inconspicuous and necrosis is not seen [15]. The osseous component may comprise trabeculae of woven or coarse lamellar bone which may have a curvilinear architecture mimicking fibrous dysplasia, have a parallel arrangement as seen in parosteal osteosarcoma or thick trabeculae with coalescent plates of bone with a mosaic pattern of cement lines mimicking Paget disease.…”

Section: Discussionmentioning

confidence: 96%

Multifocal low-grade central osteosarcoma: a rare case

2016

Self Cite

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Low-grade central osteosarcoma (LGCOS) is a rare variant of osteosarcoma. We present a rare case of multifocal LGCOS located in two distinct skeletal sites, initially noted as incidental findings on imaging for distant traumatic pathology. Both sites seemed small and innocuous on initial imaging, and were quiescent clinically, illustrating the value of close interval multimodal surveillance scanning.

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“…Treatment with wide local excision and resection essentially is curative versus marginal excision or curettage which almost always results in recurrence with possible transformation into a high-grade dedifferentiated osteosarcoma in about 15% of the cases [5, 6]. Therefore, accurate diagnosis is an essential component in survival of these patients.…”

Section: Discussionmentioning

confidence: 99%

“…Diagnosis on imaging study might be difficult and can look benign with usually some focal aggressive features [5]. …”

Section: Discussionmentioning

confidence: 99%

Low-Grade Central Osteosarcoma of the Rib: A Case Report and Brief Review of the Literature

Moghadamfalahi¹,

Alatassi²

2013

Case Reports in Pathology

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Low-grade central osteosarcoma is a rare variant of osteosarcoma which comprises less than 1-2% of all osteosarcomas. Most low-grade osteosarcomas involve long bones, most commonly distal femur, and proximal tibia. Histologically this tumor is difficult to diagnose, and an unusual location makes this diagnosis even more challenging. Here we report a case of low-grade osteosarcoma presenting as a chest wall mass involving the left 6th–8th ribs. This unusual site of presentation significantly added to the diagnostic difficulties of this rare tumor with challenging histologic features. To the best of our knowledge, only six cases of low-grade central osteosarcoma of the ribs have been reported in the English literature.

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Central low-grade osteosarcoma: a diagnostic challenge

Cited by 13 publications

References 14 publications

Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009

Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009

Multifocal low-grade central osteosarcoma: a rare case

Low-Grade Central Osteosarcoma of the Rib: A Case Report and Brief Review of the Literature

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