Low-Grade Central Osteosarcoma of the Rib: A Case Report and Brief Review of the Literature

Moghadamfalahi, Mana; Alatassi, Houda

doi:10.1155/2013/798435

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Atypical low-grade osteosarcoma is located in the intramedullary compartment and often the metaphysic or metadiaphysis around the knee frequently extends to the end of the bone, is large, and has an aggressive feature such as poor margination [3] , [4] . In our case, the age of the patient was 42 years old, in accordance with literature.…”

Section: Discussionmentioning

confidence: 99%

Low-grade intramedullary osteosarcoma presenting with multiple sclerotic bone lesions

Asdi

Kamal

2018

Radiology Case Reports

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Low-grade intramedullary osteosarcoma is a less-aggressive type of osteosarcoma for which delays in diagnosis are common. We present the case of a 42-year-old woman with complaints of low back pain. Multiple imaging evaluations and biopsy procedures were necessary to make the final diagnosis. The key radiologic feature was multiple sclerotic lesions throughout the skeleton, best seen on the bone scan. The difficulties in diagnosing this condition are evident in this case.

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Section: Discussionmentioning

confidence: 99%

Low-grade intramedullary osteosarcoma presenting with multiple sclerotic bone lesions

Asdi

Kamal

2018

Radiology Case Reports

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A case report of rib osteosarcoma and literature review

Hu,

Bao,

Yan

et al. 2023

Clinical Respiratory J

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About half of osteosarcomas occur near the knee joint, but other sites such as the humerus, upper femur, fibula, spine, and ilium can also occur. However, rib osteosarcoma is rarely reported. Here, we report the case of a 17‐year‐old female who was found to have a left dorsal mass on physical examination. Computed tomography (CT) revealed bone destruction in the seventh rib, leading to surgery for mass excision. Pathological results suggested chondroblastic osteosarcoma. After surgery, the patient was treated with chemotherapy and is doing well.

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Low-grade central osteosarcoma in proximal humerus: a rare entity

Tang

Zhou

et al. 2017

OTT

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Low-grade central osteosarcoma is a rare subtype of tumor with low-grade malignancy. Currently, wide resection with negative resection margin is the standard treatment for this disease. The role of neoadjuvant chemotherapy in low-grade central osteosarcoma was controversial and was mostly considered for tumors containing high-grade focal areas. Local tumor recurrences often exhibited a tumor with higher histologic grade or differentiation with the potential for metastases. In low-grade central osteosarcoma, timely wide resection after definite diagnosis can result in 5-year survival for almost 90%. However, the relatively nonspecific radiological and pathological findings make diagnosis very difficult. MDM2 and CDK4 are specific and provide sensitive markers for the diagnosis of low-grade central osteosarcoma, helping to differentiate low-grade central osteosarcoma from some benign lesions, including fibrous dysplasia, bone giant cell tumor, and chondrosarcoma. Here, we report the case of a 19-year-old woman with low-grade central osteosarcoma located at the proximal humerus. The affected site was rare, but the sensitive biomarkers CDK4 and MDM2 were positive. The patient recovered well after wide tumor resection following a proximal humerus endoprosthesis replacement. Our case highlighted the management strategies in low-grade central osteosarcoma. Being familiar with radiographic features, understanding the biological characteristics, and mastering diagnostic biomarkers can help oncologists avoid embarrassing situations in treatment when this rare tumor is highly suspected, even when located at an uncommon site. The discussion in this report focuses on radiographic and pathological features, advances of biomarkers that help in differential diagnosis, and current treatment options in low-grade central osteosarcoma.

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Low-Grade Central Osteosarcoma of the Rib: A Case Report and Brief Review of the Literature

Cited by 3 publications

References 11 publications

Low-grade intramedullary osteosarcoma presenting with multiple sclerotic bone lesions

Low-grade intramedullary osteosarcoma presenting with multiple sclerotic bone lesions

A case report of rib osteosarcoma and literature review

Low-grade central osteosarcoma in proximal humerus: a rare entity

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