Central Mechanisms of Pain Revealed Through Functional and Structural MRI

Davis, Karen D.; Moayedi, Massieh

doi:10.1007/s11481-012-9386-8

Cited by 318 publications

(289 citation statements)

References 170 publications

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“…Previous studies that examined structural brain alterations in pain consisted mostly of small and very specific clinical patient populations. [6][7][8][9][10][11][12][13]15 We used a hierarchical approach in studying brain structural differences. We first examined global brain tissue volumes and lobar volumes.…”

Section: Discussionmentioning

confidence: 99%

“…The hippocampus has previously been suggested as one of the altered structures in the brain in several pain states. 6,7 In women, this involvement of the limbic system, therefore, could indicate a more emotional coping of pain.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies that examined structural brain alterations in chronic pain focused on a variety of pain phenotypes, such as migraine, back pain, osteoarthritis, and fibromyalgia. [6][7][8][9][10][11][12][13][14][15] Typically, the study size was small; the largest studies included approximately 100 subjects. The small sample sizes of these studies led to a modest statistical power, thereby influencing the reproducibility of the results.…”

mentioning

confidence: 99%

“…Furthermore, each different pain phenotype showed different patterns of structural brain changes, with some overlapping regions, for example, the hippocampus. 7 Despite the possible identification of structural brain alterations in these selected clinical cases, it remains unclear which brain regions are morphologically altered in chronic pain in the general population. Therefore, in this study, after review of the existing literature, we attempted to replicate previous identified regions to find brain structures robustly associated with musculoskeletal pain.…”

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confidence: 99%

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Structural Brain Alterations in Community Dwelling Individuals with Chronic Joint Pain

Kruijf¹,

Bos²,

Huygen³

et al. 2015

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Structural Brain Alterations in Community Dwelling Individuals with Chronic Joint Pain

Kruijf¹,

Bos²,

Huygen³

et al. 2015

AJNR Am J Neuroradiol

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“…These areas are primarily involved in sensory discrimination, although abnormalities in these areas as well as in the cingulate, insula, and prefrontal cortices and the supplemental motor area are frequently reported in diverse chronic pain conditions (41). This finding might be simply due to confounding factors, such as pain or central processes directly related to fatigue.…”

Section: Discussionmentioning

confidence: 99%

Fatigue in Ankylosing Spondylitis Is Associated With the Brain Networks of Sensory Salience and Attention

Inman

Davis

2014

Arthritis & Rheumatology

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Objective. Fatigue is one of the cardinal features of ankylosing spondylitis (AS) and contributes substantially to the disability associated with this disease. The mechanisms underlying fatigue in AS remain poorly understood, and this has hampered the development of targeted, effective treatment of this disabling feature of AS. The current study was undertaken, therefore, to investigate the brain networks underlying fatigue in AS.Methods. Twenty patients with back pain secondary to AS (15 men and 5 women; mean ؎ SD age 34.8 ؎ 11.9 years) and 20 age-and sex-matched controls consented to participate in the study. Patients underwent clinical assessment of AS using the Fatigue Severity Scale, the Affect Intensity Measure, and the McGill Pain Questionnaire. Brain gray matter and white matter connectivity was assessed using 3T magnetic resonance imaging.Results. The patients with AS had significant fatigue that correlated with measures of their emotional strength and spinal mobility. Individual fatigue scores were negatively correlated with the amount of gray matter in areas of the dorsal and ventral attention networks, the somatosensory cortices, and the caudate nucleus, but were positively correlated with gray matter within the executive control network and putamen. Moreover, in patients with high fatigue scores, white matter tracts connecting these brain structures (e.g., inferior fronto-occipital fasciculi, superior/inferior longitudinal fasciculi, and corticothalamic tracts) exhibited low fractional anisotropy (indicative of decreased white matter tract integrity).Conclusion. These data indicate that fatigue in AS involves sensory salience and attention brain networks.

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Magnetic resonance imaging in neuromodulation

Downar

Davis

2015

Neuromodulation in Psychiatry

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Central Mechanisms of Pain Revealed Through Functional and Structural MRI

Cited by 318 publications

References 170 publications

Structural Brain Alterations in Community Dwelling Individuals with Chronic Joint Pain

Structural Brain Alterations in Community Dwelling Individuals with Chronic Joint Pain

Fatigue in Ankylosing Spondylitis Is Associated With the Brain Networks of Sensory Salience and Attention

Magnetic resonance imaging in neuromodulation

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