Central Nervous System Complications of Primary Atypical Pneumonia

Central nervous system manifestations of Mycoplasma pneumoniae infections

“…infection and CNS involvement is known for a long time. 1 However, the pathogenesis of CNS disease seen in association with M. pneumoniae infection is still a matter of intensive research with several potential mechanisms explaining the neurological disease after such infections. The evolution of diagnostic testing with newer molecular techniques including PCR and Western blot helped to better define this association.…”

Disseminated lntravascular Coagulation during a Fatal <i>Mycoplasma pneumoniae</i> Infection

“…This contributes to the concept that M. pneumo niae infections are essentially benign. Yet occasional patients experience overwhelming disease [4,[7][8][9][10]. In the case presented, respiratory failure occurred in association with a significant rise of M. pneumoniae comple ment fixation titer.…”

“…An overwhelming illness with fatal outcome rarely occurs [4,[7][8][9][10], Bacterial and viral infections are sometimes complicat ed by disseminated intravascular coagulation (DIC) [11]. Although hema tological complications, e.g.…”

Mycoplasma pneumoniae: Innocent Bystander or a True Cause of Central Nervous System Disease?

“…The overall incidence of CNS complications associated with M. pneumoniae infection is about 0.1% or less [1]. Among patients hospitalized with serologically confirmed M. pneumoniae infection, the incidence of such complications is between 1% and 10% [3].…”

“…The association between atypical pneumonia, of which Mycoplasma pneumoniae is considered the most common cause, and central nervous system (CNS) disease was first described in 1956 [1]. Since then, M. pneumoniae has been implicated as a cause of a variety of neurologic syndromes including aseptic meningitis, encephalitis, acute disseminated encephalomyelitis (ADEM), post-infectious hemorrhagic leukoencephalitis, acute transverse myelitis (ATM), Bickerstaff brainstem encephalitis, acute bilateral striatal necrosis, cerebellar ataxia, and stroke [2].…”