Central nervous system manifestations of lassa fever in Nigeria and the effect on mortality

Okokhere, Peter O; Bankole, Idowu A.; Akpede, George O.

doi:10.1016/j.jns.2013.07.2107

Cited by 16 publications

(32 citation statements)

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“…Neurological manifestations in patients with LF were reported in several works (Okokhere and Akpede, 2013;Okokhere et al, 2016Okokhere et al, , 2018b. However, to our knowledge, we report here the first case of LF-associated paraparesis.…”

Section: Discussionmentioning

confidence: 54%

“…In conclusion, if CNS manifestations are known complications of LF, their causative mechanisms are still poorly understood and their spectrum remains incompletely known. The case described here suggests that besides hemispheric encephalitis (Günther et al, 2001;Okokhere and Akpede, 2013;Okokhere et al, 2018b) and meningitis (Okokhere et al, 2016), delayed myelitis and brainstem encephalitis could be possible features of CNS involvement in patients with LF and might be immunologically driven. Further investigations are necessary to substantiate these hypotheses, to better understand their pathophysiology and to refine the syndromic categorization of LF related CNS disorders.…”

Section: Discussionmentioning

confidence: 80%

“…Humanto-human transmission is mainly reported in a nosocomial context (Houlihan and Behrens, 2017). Central nervous system (CNS) disorders associated with LF, including encephalitis and meningitis, have been described previously (Günther et al, 2001;Okokhere and Akpede, 2013;Okokhere et al, 2016Okokhere et al, , 2018b and are associated with an increased number of deaths (Okokhere and Akpede, 2013;Okokhere et al, 2018a). Here we report a case of delayed-onset paraparesis in an LF survivor.…”

Section: Introductionmentioning

confidence: 86%

See 2 more Smart Citations

Delayed-onset paraparesis in Lassa fever: A case report

Duvignaud

Doutchi

Abejegah

et al. 2020

International Journal of Infectious Diseases

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Lassa fever (LF) is an endemic viral hemorrhagic fever in West Africa. Among the serious complications of the disease are neurological manifestations whose spectrum is incompletely known. Here we report the case of a 61-year-old man who developed a delayed-onset paraparesis a few weeks after getting infected with Lassa virus, thereby suggesting a possible association between LF and spinal cord disorders.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 86%

See 1 more Smart Citation

Delayed-onset paraparesis in Lassa fever: A case report

Duvignaud

Doutchi

Abejegah

et al. 2020

International Journal of Infectious Diseases

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“…Our case series shed more light on the clinical features of this disease and showed that LAV is an important cause of aseptic (viral) meningitis in areas endemic for Lassa fever. Therefore, we advocate that LAV should be added to the list of aetiological agents for aseptic meningitis in areas endemic for Lassa fever, especially since it has been shown that varying neurological manifestations occur in Lassa fever infection in Nigeria [17]. …”

Section: Discussionmentioning

confidence: 99%

Aseptic Meningitis Caused by Lassa Virus: Case Series Report

Okokhere

Bankole

Iruolagbe

et al. 2016

Case Reports in Neurological Medicine

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The Lassa virus is known to cause disease in different organ systems of the human body, with varying clinical manifestations. The features of severe clinical disease may include bleeding and/or central nervous system manifestations. Whereas Lassa fever encephalopathy and encephalitis are well described in the literature, there is paucity of data on Lassa virus meningitis. We present the clinical description, laboratory diagnosis, and management of 4 consecutive cases of aseptic meningitis associated with Lassa virus infection without bleeding seen in a region of Nigeria known to be endemic for both the reservoir rodent and Lassa fever. The 4 patients recovered fully following intravenous ribavirin treatment and suffered no neurologic complications.

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“…Lassa fever (LF) is endemic in Nigeria, particularly in Edo State [ 1 ]. In severe cases, LF may present with central nervous system (CNS) features, when it often indicates the late stage of the disease [ 2 , 3 , 4 , 5 ], and is usually associated with bleeding and poor prognosis [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Acute Lassa Virus Encephalitis with Lassa Virus in the Cerebrospinal Fluid but Absent in the Blood: A Case Report with a Positive Outcome

et al. 2018

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It is rare both to have the central nervous system (CNS) as the main focus in the acute phase of Lassa fever infection without associated bleeding, and to find Lassa virus (LAV) in the cerebrospinal fluid (CSF) but not in the serum. We report the case of a 38-year-old Nigerian woman with mainly CNS manifestation of Lassa fever. She was admitted twice within 11 days because of persistent fever. A clinical diagnosis of acute LAV encephalitis was made because of a high index of suspicion and CNS involvement confirmed by positive reverse transcriptase polymerase chain reaction (RT-PCR) for LAV in the CSF, while her blood was repeatedly negative for LAV by RT-PCR test. She recovered fully following supportive care coupled with treatment with an 18-day course of ribavirin, and suffered no long-term neurological complication or relapse. Post-treatment CSF examination by RT-PCR did not detect LAV.

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Central nervous system manifestations of lassa fever in Nigeria and the effect on mortality

Cited by 16 publications

References 0 publications

Delayed-onset paraparesis in Lassa fever: A case report

Delayed-onset paraparesis in Lassa fever: A case report

Aseptic Meningitis Caused by Lassa Virus: Case Series Report

Acute Lassa Virus Encephalitis with Lassa Virus in the Cerebrospinal Fluid but Absent in the Blood: A Case Report with a Positive Outcome

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