Central nervous system meningiomas in the first two decades of life: a clinicopathological analysis of 87 patients

Rushing, Elisabeth J.; Olsen, Cara; Mena, Hernando; Rueda, Maria-Eugenia; Lee, Youn-Soo; Keating, Robert F.; Packer, Roger J.; Santi, Mariarita

doi:10.3171/ped.2005.103.6.0489

Cited by 63 publications

(92 citation statements)

References 43 publications

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“…Meningiomas are relatively common tumors in adults and account for approximately 20% of all intracranial tumors 1 . Their incidence ranges from 1.1% to 4.2% of all intracranial tumor in pediatric age and in this corresponds to a proportion varying from 2,8% to 5,9% of meningiomas in all ages 2,3 . Meningiomas in children predominate during the second decade and are extremely uncommon in infancy.…”

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“…Meningiomas in children predominate during the second decade and are extremely uncommon in infancy. In children, meningiomas appear in unusual sites and usually reach enormous sizes, and locations that are rare in adults 2,3 . Meningiomas in the pineal region may originate either from the velum interpositum or from the falcotentorial junction.…”

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“…Lack of dural attachment is one of the clinical characteristics of meningiomas in children: around 36% are not dural-based tumors 2,3 .…”

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Meningiomas of pineal region in children

Matushita

Pinto

Plese

2007

Arq. Neuro-Psiquiatr.

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-Meningiomas are uncommon tumors in children and either more rarely encountered in the pineal region. We report two cases of meningioma of the pineal region in children. One of these cases was a five years-old girl and the other a one year-old boy. No specific clinical presentation or tomographic examinations findings was identified before treatment, suggestive of a diagnosis of menigioma. The clinical and laboratory features were very similar to the most common tumors of the pineal region. Prior to the surgery, the histology of these tumors was not suspected. Both patients underwent direct surgery and complete removal was achieved by a suboccipital transtentorial approach. The tumors originated from velum interpositum in both cases. At the follow up, one case presented with recurrence six years later, and she underwent a reoperation with total resection without morbidity. Long-term follow up presented no other recurrences.KEY WORDS: meningiomas, meningeal neoplams, pineal tumors, velum interpositum, falcotentorial junction, children. Meningiomas da região da pineal em criançasRESUMO -Meningiomas são tumores poucos frequentes em crianças, e mais raramente encontrados na região da pineal. Relatamos dois casos de meningioma da região da pineal em crianças, uma menina de cinco anos e um menino de um ano de idade. Não foi identificada nenhuma forma de apresentação clinica ou caracteristica tomográfica, antes do tratamento, que sugerisse o diagnóstico de meningioma. As características clinicas e laboratoriais encontradas foram similares às de tumores mais frequentes da região da pineal. Ambos os pacientes foram submetidos ao tratamento cirúrgico e a remoção completa foi obtida por abordagem suboccipital transtentorial. Durante o seguimento, um dos pacientes foi reoperado por recorrencia do tumor seis anos após o tratamento inicial. Atualmente, os pacientes encontram-se livres de recorrência tumoral.PALAVRAS-CHAVE: meningioma, neoplasia meningea, velum interpositum, junção falcotentorial, crianças. Dr. Hamilton Matushita -Rua Barata Ribeiro 237 / 43/44/46 -01308-000 São Paulo SP -Brasil. E-mail: neurosp@uol.com.brLiterature specifically concerning to meningioma of the pineal region in children is scarce. Meningiomas are relatively common tumors in adults and account for approximately 20% of all intracranial tumors 1 . Their incidence ranges from 1.1% to 4.2% of all intracranial tumor in pediatric age and in this corresponds to a proportion varying from 2,8% to 5,9% of meningiomas in all ages 2, 3 . Meningiomas in children predominate during the second decade and are extremely uncommon in infancy. In children, meningiomas appear in unusual sites and usually reach enormous sizes, and locations that are rare in adults 2,3 . Meningiomas in the pineal region may originate either from the velum interpositum or from the falcotentorial junction.We are describing our experience with two cases of meningiomas in the pineal region in children arising within the velum interpositum, with no dural attachment. Lack of dural...

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Meningiomas of pineal region in children

Matushita

Pinto

Plese

2007

Arq. Neuro-Psiquiatr.

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“…Intracranial meningiomas, the most common central nervous system (CNS) tumors, account for ~30% of all CNS tumors in adults, whereas pediatric intracranial meningiomas are rare, comprising only 0.4-4.6% of all pediatric primary intracranial tumors (1,2). As pediatric intracranial meningiomas are rare, there is little available information on their epidemiology, treatment and prognosis.…”

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Pulmonary and pleural metastasis of intracranial anaplastic meningioma in a 3-year-old boy: A case report

Honda

Shirayama

Morita

et al. 2017

Molecular and Clinical Oncology

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Abstract. In adults, meningiomas occasionally display aggressive behavior and may occasionally metastasize. By contrast, pediatric meningiomas are rare, and there is limited information regarding their clinical characteristics, treatment and prognosis. We herein report the case of a 3-year-old boy with anaplastic meningioma with a history of local recurrence and late pulmonary metastasis. At diagnosis, a 70-mm mass lesion in was identified in the right frontal lobe, with intratumoral hemorrhage. The tumor was attached to the falx cerebri and was completely resected. The histological diagnosis was anaplastic meningioma, World Health Organization grade III. Two months after the surgery, the meningioma recurred at the same site. Although the patient received radiotherapy after a second operation, the tumor metastasized to the lung and pleura 8 months after the initial operation. The metastasis was resistant to treatment, even after gross total resection, and the effectiveness of further radiotherapy was limited. The patient succumbed to the disease 1 year and 4 months after the initial diagnosis. The findings of the present case and a review of the relevant literature suggest that recurrence and metastasis of meningiomas are difficult to predict. Therefore, such patients should be carefully monitored throughout the follow-up period.

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“…[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Among them, Ki-67 (MIB-1), a tumor proliferation antigen, appears to be the best and is widely accepted as a biomarker for meningioma prognosis. As a general rule, the Ki-67 proliferation index correlates well with WHO tumor grade for meningioma.…”

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The Oncofetal Protein IMP3: A Novel Molecular Marker to Predict Aggressive Meningioma

Hao¹,

Smith²,

Chu³

et al. 2011

Archives of Pathology &Amp; Laboratory Medicine

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N Context.-One of the major clinical challenges is to predict recurrence of meningioma. Recently, we have found that IMP3, an oncofetal RNA-binding protein, is a biomarker to predict aggressive tumors.Objective.-To investigate whether IMP3 can be used as a new biomarker to predict the recurrence and overall survival of patients with meningiomas.Design.-One hundred seven patients with primary meningiomas were investigated for expression of IMP3 by immunohistochemistry and whether expression of this molecule correlated with tumor recurrence and overall survival.Results.-Tumor recurrence was found in 13 of 107 patients with primary meningioma. Seven of 107 patients (6.5%) with primary meningiomas expressed IMP3. Kaplan-Meier plots and log-rank tests showed that patients with IMP3-positive tumors had a much higher recurrence rate (P = .004) and a poorer overall survival (P , .001) than did patients with IMP3-negative tumors. The 5-year recurrence-free and overall survival rates were 0% and 36% in IMP3-positive patients versus 89% and 94% in IMP3-negative patients, respectively. Multivariable analysis of IMP3 status (positive versus negative) in primary tumors showed a hazard ratio of 17.89 for recurrence (P = .01), which was much higher than hazard ratios associated with all other known risk factors including higher tumor grades and Ki-67 labeling index.Conclusions.-IMP3 is a potential independent prognostic biomarker that can be used at the time of initial diagnosis of meningioma to identify patients who have a high risk of developing a recurrence.

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Central nervous system meningiomas in the first two decades of life: a clinicopathological analysis of 87 patients

Cited by 63 publications

References 43 publications

Meningiomas of pineal region in children

Meningiomas of pineal region in children

Pulmonary and pleural metastasis of intracranial anaplastic meningioma in a 3-year-old boy: A case report

The Oncofetal Protein IMP3: A Novel Molecular Marker to Predict Aggressive Meningioma

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