Central neurocytoma in the posterior fossa

Rai, Pranav; Nayak, Raghavendra; Anand, Debish; Menon, Girish

doi:10.1136/bcr-2019-231626

Cited by 5 publications

(8 citation statements)

References 8 publications

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“…In 1982, Hassoun et al initially described CN as a benign tumor with a characteristically distinct histopathological and radiological profile than other intraventricular tumors [ 6 ]. Based on the World Health Organization classification, CN is regarded as a low-grade tumor (Grade II) [ 3 ]. CN has no sex-specific predominance [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…CN has no sex-specific predominance [ 2 ]. It frequently afflicts patients in the age group of 20-40 years with a mean age of 30 years [ 3 , 7 ]. Likewise, our case of a 35-year-old female belonged to the most commonly affected age group.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, radiotherapy has been demonstrated to decrease the rate of tumor proliferation. Thus, postoperative radiotherapy is used for CNs with proliferation or patients with incomplete resection of CNs [ 3 ]. A five-year survival rate following total and subtotal excision is 99% and 86%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…It arises from the germinal matrix cells located in the septum pellucidum or the periventricular region [ 1 , 2 ]. CNs are rare and constitute 0.1-0.5% of all brain tumors [ 3 ]. Young adults are mostly affected and nearly a quarter of patients are in their fourth decade.…”

Section: Introductionmentioning

confidence: 99%

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Central Neurocytoma: A Case Report With Literature Review

Sachani,

Dhande,

Parihar

et al. 2024

Cureus

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Central neurocytoma (CN) is a rare, low-grade, neuronal tumor frequently encountered in young adults. Complete surgical resection is the treatment of choice; however, it is associated with grave postoperative complications in a quarter of patients, including neurological (motor weakness, memory deficit, aphasia, and seizure) as well as regional (hydrocephalus, hematoma, infection, and subcutaneous hydrops) complications. Herein, we present a case of a 35-year-old female who presented with decreased vision for the last 7-8 days and headache over the last 1-1.5 years. An ophthalmologic examination suggested papilledema. Magnetic resonance imaging (MRI) of the brain illustrated a well-circumscribed, large, lobulated, altered signal intensity midline intraventricular lesion (72 × 68 mm) attached to the septum pellucidum near the foramen of Monro (FoM) most likely to be CN. The patient underwent complete surgical resection but required re-exploration the next day for hematoma removal due to intraventricular hemorrhage. Over the next 40 days, the patient developed hydrocephalus with transtentorial herniation and succumbed. Histopathological examination (HPE) was suggestive of CN and immunohistochemistry (IHC) was strongly positive for synaptophysin, thus confirming the diagnosis of CN.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Central Neurocytoma: A Case Report With Literature Review

Sachani,

Dhande,

Parihar

et al. 2024

Cureus

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“…CN is a rare intracranial tumor that accounts for 0.1%-0.5% of all intracranial tumors and is classified as a grade II tumor by the World Health Organization in 2021 (1,4,5). CN commonly occurs in the lateral ventricle but is also found in the posterior fossa or other locations (6). Its pathogenesis is associated with various chromosomal aberrations (7).…”

Section: Discussionmentioning

confidence: 99%

Clinical prognostic factors for central neurocytoma and subgroup analysis of different treatment measures: A SEER database-based retrospective analysis from 2003 to 2019

Zhang

Yu²,

Zhang³

et al. 2023

Front. Oncol.

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PurposeThe study aimed to identify clinical prognostic factors affecting overall survival (OS) in patients with central neurocytoma (CN) and to determine independent prognostic factors in the subgroups of different treatment modalities using a retrospective analysis based on the SEER database from 2003 to 2019.Materials and methodsData regarding patients with CN, including basic clinical characteristics, treatment measures, and prognosis follow-up, were extracted from the SEER database. The prognostic variables for all patients were assessed using log-rank test as well as univariate and multivariate analyses based on the Cox proportional hazards model. The same statistical methods were used for analysis in different subgroups of gross total resection (GTR), subtotal resection (STR), no surgery, radiotherapy (RT), and no RT.ResultsIn total, 413 patients were enrolled in this study. Tumor size, primary site surgery, and RT were independent prognostic factors in all patients with CN. In subgroup analyses, RT was not an independent prognostic factor in patients with GTR. However, sex and race were independent prognostic factors in patients with STR. Additionally, tumor size was an independent prognostic factor in patients who did not undergo surgery. Furthermore, sex and primary site were independent prognostic factors in patients who received RT. Size and primary site surgery were independent prognostic factors in patients without RT.ConclusionIn our study, patients with small tumors or GTR or those who did not receive RT showed a better prognosis. GTR was the preferred treatment for CN. RT was not recommended for patients after GTR. Men and African American showed certain advantages after STR surgery. Tumors with a size of >4 cm were recommended for active treatment. In the RT subgroup, patients with tumors outside the ventricle or women had a poorer prognosis than those with tumors within the ventricle or men, respectively. These findings will help clinicians and patients understand the treatment and prognosis of CN visually and intuitively.

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