Central Obesity in Children with Psoriasis

Guidolin, Lucia; Borin, Marco; Fontana, Elena; Caroppo, Francesca; Piaserico, Stefano; Fortina, Anna Belloni

doi:10.2340/00015555-2816

Cited by 23 publications

(13 citation statements)

References 9 publications

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“…The same trend has been observed in adults. 2,7,[14][15][16][17][18] and is independent of the clinical type of psoriasis. A family history of being overweight or obese is the major risk factor for obesity in children with psoriasis.…”

Section: Comorbidities Obesitymentioning

confidence: 98%

<p>Optimal Management of Plaque Psoriasis in Adolescents: Current Perspectives</p>

Mahé

2020

PTT

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The skin is at the interface between the body and its environment and is therefore at the center of adolescent concerns during this period of identity formation and increased awareness of body image issues, and stigmatization. Managing an adolescent with psoriasis involves managing the illness and the individual during their transition from being an older child to a young adult. In addition to ensuring that the patient adheres to treatments and is engaged with the therapeutic strategy, dermatologists may also need to manage issues linked to unspoken suffering or conflicts between the adolescent and their parents, who are often present during consultations. The impact of psoriasis on the social interactions, school life and sexuality of the patients, together with the influence of the internet and social networks, also have to be taken into account. In this review, we summarize the epidemiologic, clinical, and therapeutic data available on psoriasis in adolescents, and propose specific management strategies, adapted to the 21st century, for patients in this age group.

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Section: Comorbidities Obesitymentioning

confidence: 98%

<p>Optimal Management of Plaque Psoriasis in Adolescents: Current Perspectives</p>

Mahé

2020

PTT

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“…On the other hand, the incidence of psoriasis in obese children has begun to gain appreciation. Compelling evidence has demonstrated that the pediatric psoriasis is associated with a risk of pediatric metabolic syndromes [32–35], indicating an association between psoriasis and obesity in children and emphasizing the importance of careful assessment of metabolic comorbidities in psoriatic youngsters.…”

Section: Relationship Between Obesity and Psoriasis Focusing On The Pmentioning

confidence: 99%

New insights into different adipokines in linking the pathophysiology of obesity and psoriasis

Kong

Zhang

et al. 2019

Lipids Health Dis

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Psoriasis is a chronic, systemic, hyper-proliferative immune-mediated inflammatory skin disease. The results of epidemiological investigations have shown that psoriasis affects around 2% of the general population worldwide, and the total number of psoriasis patients is more than 6 million in China. Apart from the skin manifestations, psoriasis has been verified to associate with several metabolic comorbidities, such as insulin resistance, diabetes and obesity. However, the underlying mechanism is still not elucidated. Adipocytes, considered as the active endocrine cells, are dysfunctional in obesity which displays increased synthesis and secretion of adipokines with other modified metabolic properties. Currently, growing evidence has pointed to the central role of adipokines in adipose tissue and the immune system, providing new insights into the effect of adipokines in linking the pathophysiology of obesity and psoriasis. In this review, we summarize the current understanding of the pathological role of adipokines and the potential mechanisms whereby different adipokines link obesity and psoriasis. Furthermore, we also provide evidence which identifies a potential therapeutic target aiming at adipokines for the management of these two diseases.

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“…Previous studies on children and adolescents with psoriasis have found some of these comorbidities, or risk factors thereof, to be increased 11 23–26. Since these studies have mainly been done in highly selected hospital-treated populations, with small sample sizes, or by retrospectively reviewing, for example, patient records, we wished to investigate paediatric psoriasis in a more general population, and also to include psoriasis-free controls for comparison, with the possibility of prospective data collection 11 23–49. We therefore established a well-characterised clinical cohort nested in a large, nationwide birth cohort in Denmark in order to investigate the clinical characteristics, trigger factors, comorbidities and related risk factors and genotype of paediatric psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Cohort profile: the clinical ‘Psoriasis in Adolescents’ (PIA) cohort in Denmark

et al. 2019

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PurposePsoriasis is a chronic inflammatory skin disease that frequently debuts in childhood and adolescence. We wished to determine environmental and genetic risk factors for the development of psoriasis in children and adolescents, as well as to investigate debut type, trigger factors, course of disease, nature and influence of stress related to both child and family and risk factors for comorbidity. The ‘Psoriasis in Adolescents’ (PIA) cohort will provide data on the relationship between psoriasis and, respectively, genetic disposition, early-life exposures, quality of life and comorbidity.ParticipantsThe PIA cohort is nested in the large general population Danish National Birth Cohort (DNBC). We invited 390 adolescents with psoriasis and corresponding maternally predisposed and non-predisposed controls. Participants underwent an interview and a clinical examination consisting of a skin inspection and physical measurements including blood sampling and microbiological swabs. Additionally, four self-administered questionnaires on physical and mental health were completed.Findings to dateThe final PIA cohort consists of 81 adolescents with psoriasis, 110 parentally predisposed and 124 non-predisposed psoriasis-free adolescents. The validity of the maternally reported psoriasis status from the DNBC was found to be low on clinical examination (47.5%). In contrast, the self-reported psoriasis status of the DNBC mothers was clinically confirmed in 80.8% of the cases.Future plansThe PIA cohort offers the possibility of assessing the clinical characteristics, course of psoriasis and development of comorbidities in adolescents with clinically confirmed disease from a general population. Comparison with predisposed and non-predisposed controls is possible and genetic analyses are scheduled. We plan to invite the participants for a follow-up in 5–10 years. Furthermore, we plan to include newly diagnosed adolescents with psoriasis from the 18-year DNBC follow-up. All information is linkable on the individual level with data from the DNBC and nationwide registries in Denmark.

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Central Obesity in Children with Psoriasis

Abstract: This is an open access article under the CC BY-NC license. www.medicaljournals.se/acta

Cited by 23 publications

References 9 publications

<p>Optimal Management of Plaque Psoriasis in Adolescents: Current Perspectives</p>

<p>Optimal Management of Plaque Psoriasis in Adolescents: Current Perspectives</p>

New insights into different adipokines in linking the pathophysiology of obesity and psoriasis

Cohort profile: the clinical ‘Psoriasis in Adolescents’ (PIA) cohort in Denmark

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