Central Pontine Myelinolysis as a Manifestation of the Paraneoplastic Syndrome

Hardjasudarma, Mardjohan; Husain, Fahd; Fowler, Marjorie; Rl, Eisenberg; Mirfakhraee, Mansour

doi:10.1097/00007611-199204000-00019

Cited by 3 publications

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“…Previously, another case of lung carcinoma and CPM was reported, but associated with SIADH [6]. CPM was also observed in 2 cases of nasopharyngeal carcinoma after cisplatin chemotherapy.…”

Section: Discussionmentioning

confidence: 90%

Cerebellar Ataxia with Complete Clinical Recovery and Resolution of MRI Lesions Related to Central Pontine Myelinolysis: Case Report and Literature Review

et al. 2010

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There are several reports of central pontine myelinolysis (CPM) in a setting of malnutrition, alcoholism, and chronic debilitating illness associated with electrolyte abnormalities, especially hyponatremia. The cause of myelinolysis is still under debate, and, although osmotic effects are thought to be responsible in most cases, alternative pathological factors should be considered [King et al.: Am J Med Sci 2010;339:561–567]. We report a case of CPM in a patient with recent chemotherapy for colon cancer without electrolyte unbalance and otherwise unexplained causes. Moreover, the present case is an example of the unusual clinical ataxic variant, followed by complete recovery without any specific treatment. The diagnosis was confirmed by MRI, which showed a characteristic hyperintense signal abnormality in the central part of the pons with an unaffected outer rim. One month later, we observed complete resolution of clinical and radiological symptoms.

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“…Previously, another case of lung carcinoma and CPM was reported, but associated with SIADH [6]. CPM was also observed in 2 cases of nasopharyngeal carcinoma after cisplatin chemotherapy.…”

Section: Discussionmentioning

confidence: 90%