Central Processing in Tinnitus: fMRI Study Outlining Patterns of Activation Using an Auditory Discrimination Task in Normal Versus Tinnitus Patients

Zenke, Julianna; Rahman, Samiha; Guo, Qi; Leung, Ada; Gomaa, Nahla

doi:10.1097/mao.0000000000003194

Cited by 7 publications

(21 citation statements)

References 66 publications

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“…Gray matter atrophy gradually spread from the basal ganglia to the angular gyrus, temporal regions, and eventually to the subcortical-cortical network as neurological disease progresses. The angular gyrus was key AD-risk region ( Browndyke et al, 2021 ; Zenke et al, 2021 ). The calcarine sulcus was located posterior to the medial surface of the hemisphere.…”

Section: Discussionmentioning

confidence: 99%

Research on Voxel-Based Features Detection and Analysis of Alzheimer’s Disease Using Random Survey Support Vector Machine

Meng

Liu

et al. 2022

Front. Neuroinform.

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Alzheimer’s disease (AD) is a degenerative disease of the central nervous system characterized by memory and cognitive dysfunction, as well as abnormal changes in behavior and personality. The research focused on how machine learning classified AD became a recent hotspot. In this study, we proposed a novel voxel-based feature detection framework for AD. Specifically, using 649 voxel-based morphometry (VBM) methods obtained from MRI in Alzheimer’s Disease Neuroimaging Initiative (ADNI), we proposed a feature detection method according to the Random Survey Support Vector Machines (RS-SVM) and combined the research process based on image-, gene-, and pathway-level analysis for AD prediction. Particularly, we constructed 136, 141, and 113 novel voxel-based features for EMCI (early mild cognitive impairment)-HC (healthy control), LMCI (late mild cognitive impairment)-HC, and AD-HC groups, respectively. We applied linear regression model, least absolute shrinkage and selection operator (Lasso), partial least squares (PLS), SVM, and RS-SVM five methods to test and compare the accuracy of these features in these three groups. The prediction accuracy of the AD-HC group using the RS-SVM method was higher than 90%. In addition, we performed functional analysis of the features to explain the biological significance. The experimental results using five machine learning indicate that the identified features are effective for AD and HC classification, the RS-SVM framework has the best classification accuracy, and our strategy can identify important brain regions for AD.

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Section: Discussionmentioning

confidence: 99%

Research on Voxel-Based Features Detection and Analysis of Alzheimer’s Disease Using Random Survey Support Vector Machine

Meng

Liu

et al. 2022

Front. Neuroinform.

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“…Atrophy of the flocculus on the surgical side has been suggested to modulate tinnitus [ 15 , 16 ]. Functional MRI revealed that tinnitus is associated with activities of the Heschl’s gyrus, angular gyrus, cerebellar, and limbic system [ 17 ]. Arachnoid cysts are a benign malformation of the arachnoid layer of the meninges.…”

Section: Discussionmentioning

confidence: 99%

Tinnitus Triggered by a Cerebellopontine Arachnoid Cyst in an Adolescent

Olsson

Ulualp²,

Kou³

2022

Am J Case Rep

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Patient: Female, 14-year-old Final Diagnosis: Arachnoid cyst • tinnitus Symptoms: Tinnitus Medication: — Clinical Procedure: Audiogram • MRI Specialty: Otolaryngology Objective: Rare coexistence of disease or pathology Background: Tinnitus can be a symptom of a wide range of disorders. The identification and treatment of the underlying condition is essential for management of tinnitus in children. Tinnitus can occur with medical conditions other than sensorineural hearing loss. Cerebellopontine arachnoid cysts are rare and can cause tinnitus and hearing loss in adults. Tinnitus caused by an arachnoid cyst has not been reported in an adolescent. We report clinical and radiological features of a teenager with bothersome tinnitus caused by an arachnoid cyst. Case Report: A 14-year-old girl with unilateral tinnitus for 10 months presented to the Pediatric Otolaryngology Clinic. The loudness and duration of tinnitus had progressed gradually. Turning the head to the right induced right otalgia and tinnitus. The patient denied hearing loss, vertigo, exposure to loud noise, feeling of fullness in ear, otorrhea, facial weakness, numbness, dysphagia, changes in smell or taste, and problems with the jaw or temporomandibular joint. The focused neurological examination and head and neck examination were within normal limits. The patient had normal hearing on audiometry. T1-weighted, T2-spin-echo, T2-FLAIR, and diffusion-weighted magnetic resonance imaging sequences were obtained, revealing a right cerebellopontine angle arachnoid cyst. After arachnoid cyst marsupialization, the patient’s tinnitus and otalgia resolved. Conclusions: This case highlights the importance of suspecting identifiable nonauditory system disorders as causes of tinnitus in children. Thorough analysis of clinical findings and timely use of imaging is critical to prevent delay in diagnosis and treatment of children with bothersome tinnitus caused by rare medical conditions.

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“…Table 2 and Figure 3 show the frequency distribution of functional brain regions reported among the studies; 13 studies assessed the auditory cortex, of which 7 showed higher activation in the tinnitus group than controls, 21,23,25,30,35,37,38 while the remaining 6 showed no significantly higher activation. 27,29,31,32,34,36 The inferior colliculus (IC) was assessed in 10 studies, displaying greater activation in tinnitus patients than controls in 7 studies, 24,27,29,30,34,35,38 lower activation in 1 study, 22 and no difference in 2 studies.…”

Section: Roimentioning

confidence: 99%

“…42 Supporting this theory, Zenke et al observed an increased auditory cortex activation. 37 The authors suggest that a limbic-auditory interaction may be to blame for the presence of tinnitus. This study also implied that the primary auditory centers may experience asymmetries in metabolic activity that lead to downstream effects in tinnitus subjects.…”

Section: Auditory Cortex (Figure 4)mentioning

confidence: 99%

Functional Brain Regions Linked to Tinnitus Pathology and Compensation During Task Performance: A Systematic Review

Jimoh

Marouf

Zenke

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveTo systematically search the literature and organize relevant advancements in the connection between tinnitus and the activity of different functional brain regions using functional magnetic resonance imaging (fMRI).Data SourcesMEDLINE (OVID), EMBASE (OVID), CINAHL (EBSCO), Web of Science, ProQuest Dissertations & Theses Global, Cochrane Database of Systematic Reviews, and PROSPERO from inception to April 2022.Review MethodsStudies with adult human subjects who suffer from tinnitus and underwent fMRI to relate specific regions of interest to tinnitus pathology or compensation were included. In addition, fMRI had to be performed with a paradigm of stimuli that would stimulate auditory brain activity. Exclusion criteria included non‐English studies, animal studies, and studies that utilized a resting state magnetic resonance imaging or other imaging modalities.ResultsThe auditory cortex may work to dampen the effects of central gain. Results from different studies show variable changes in the Heschl's gyrus (HG), with some showing increased activity and others showing inhibition and volume loss. After controlling for hyperacusis and other confounders, tinnitus does not seem to influence the inferior colliculus (IC) activation. However, there is decreased connectivity between the auditory cortex and IC. The cochlear nucleus (CN) generally shows increased activation in tinnitus patients. fMRI evidence indicates significant inhibition of thalamic gating. Activating the thalamus may be of important therapeutic potential.ConclusionPatients with tinnitus have significantly altered neuronal firing patterns, especially within the auditory network, when compared to individuals without tinnitus. Tinnitus and hyperacusis commonly coexist, making differentiation of the effects of these 2 phenomena frequently difficult.

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Central Processing in Tinnitus: fMRI Study Outlining Patterns of Activation Using an Auditory Discrimination Task in Normal Versus Tinnitus Patients

Cited by 7 publications

References 66 publications

Research on Voxel-Based Features Detection and Analysis of Alzheimer’s Disease Using Random Survey Support Vector Machine

Research on Voxel-Based Features Detection and Analysis of Alzheimer’s Disease Using Random Survey Support Vector Machine

Tinnitus Triggered by a Cerebellopontine Arachnoid Cyst in an Adolescent

Functional Brain Regions Linked to Tinnitus Pathology and Compensation During Task Performance: A Systematic Review

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