Central Serotoninergic Stimulation by Fenfluramine Challenge Does Not Affect Plasma Thyrotropin-Stimulating Hormone Levels in Man

Coccaro, Emil F.; Siever, Larry J.; Kourides, Ione A.; Adan, Federico; Campbell, Graeme; Davis, Kenneth L.

doi:10.1159/000124924

Cited by 20 publications

(11 citation statements)

References 27 publications

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“…After stimulation with dl-FEN no change (Sulaiman et al, 1975;Casanuevaetal., 1984;Lewisand Sherman, 1985;Weizmann et al, 1988) or just a slight increase (Murialdo et al, 1979;Lopez-Ibor et al, 1988) in growth hormone (HGH) secretion in humans has been reported. Furthermore, Coccaro et al (1988) were unable to document any influence of dl-FEN on TSH secretion in healthy young males, indicating that central serotonergic activity does not play an important role in the physiologie release ofplasma TSH in this population.…”

Section: Introductionmentioning

confidence: 68%

Multiple Hormone Responses to Stimulation with dl-Fenfluramine in Patients with Major Depression before and after Antidepressive Treatment

Kasper

Vieira²,

Schmidt³

et al. 1990

Pharmacopsychiatry

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The authors investigated 31 drug-free inpatients with major depression using dl-fenfluramine (dl-FEN) as a serotonin probe (fenfluramine stimulation test, FFT). The FFT was performed in the same individuals (intraindividual comparison) with and without application of dl-FEN and before and after antidepressive treatment. Blood samples were analyzed for prolactin, cortisol, thyrotropin (TSH), growth hormone (HGH), dl-FEN and its major metabolite dl-norfenfluramine. There was no difference in the conditions before and after treatment as regards peak plasma levels of dl-FEN. Compared with saline, significant (P less than 0.01) increases were detected for dl-FEN-stimulated cortisol and prolactin values. A significantly (P less than 0.01) lower increase in dl-FEN-stimulated prolactin values was found after treatment compared with the situation before treatment, a finding which was dependent on the type of medication which the patients were receiving at the time when the test procedure took place. Baseline and dl-FEN-stimulated cortisol values were significantly (P less than 0.001) lower and TSH values were significantly (P less than 0.01) higher in the condition after compared with the one before treatment. Patients' mean peak delta prolactin responses to dl-FEN before treatment were significantly (P less than 0.05) correlated with those of patients after subchronic treatment with fluvoxamine. Hormonal responses were neither associated with the severity of the illness nor with a specific psychopathological profile.

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Section: Introductionmentioning

confidence: 68%

Multiple Hormone Responses to Stimulation with dl-Fenfluramine in Patients with Major Depression before and after Antidepressive Treatment

Kasper

Vieira²,

Schmidt³

et al. 1990

Pharmacopsychiatry

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“…(46) concluded that d,l‐fenfluramine does not have a detectable effect on dopamine in men. Fenfluramine is administrated orally (60 mg d,l‐mixture, 30 mg d‐mixture) and appears to be well tolerated by healthy subjects (47).…”

Section: Dl‐fenfluraminementioning

confidence: 99%

Serotonergic dysregulation in bipolar disorders: a literature review of serotonergic challenge studies

et al. 2002

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The literature on 5-HT challenge procedures in BD shows evidence for a blunted prolactin (PRL) in mania and depression as well as a blunted cortisol in euthymic BD patients. This suggests that in both mania and depression similar changes in the 5-HT system are involved. It is speculated that blunting of cortisol responses in euthymic BD patients may be a result of chronically altered 5-HT functioning, whereas changes in PRL release following 5-HT challenges reflect more state-dependent changes in 5-HT activity. The 5-HT responsivity in BD patients has also been associated with pharmacological treatment, suicidal behaviour, weight loss and age. Recommendations for future research are given.

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“…Furthermore, serotonin appears to be involved in nyctohemeral TSH periodicity [31]. In man, several investigators failed to demonstrate a measurable influence of serotonin on basal TSH secretion [3, 4, 5, 32], whereas serotonin was able to stimulate pituitary TSH release in vitro [33]. We could not find an influence of serotonin on basal TSH secretion.…”

Section: Discussionmentioning

confidence: 54%

“…Several studies have addressed the role of serotonin on prolactin [1, 2], LH [1, 3, 4] and TSH [3, 4, 5] secretion in men and normal cycling women.…”

Section: Introductionmentioning

confidence: 99%

Serotoninergic Involvement in Gonadotropin and TSH Secretion in Normal Cycling and Postmenopausal Women

Krause

Møller²,

Schmeisser³

1998

Horm Res Paediatr

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We investigated the influence of a specific serotonin receptor blockade on pituitary hormone secretion in normal cycling women and postmenopausal women not receiving hormone replacement therapy. Serotonin receptor blockade was performed by using the HT-3 receptor subtype antagonist ondansetron as an i.v. bolus injection of 8 mg. Blood samples were taken before as well as 20, 30 and 40 min after ondansetron administration for the estimation of LH, FSH, and TSH. We could not find any hormonal changes in the normal cycling women. The postmenopausal women showed a significant decline in LH secretion, whereas FSH and TSH levels remained unchanged. Our results suggest serotoninergic involvement in LH secretion in postmenopausal hypoestrogenic hypergonadism.

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Central Serotoninergic Stimulation by Fenfluramine Challenge Does Not Affect Plasma Thyrotropin-Stimulating Hormone Levels in Man

Cited by 20 publications

References 27 publications

Multiple Hormone Responses to Stimulation with dl-Fenfluramine in Patients with Major Depression before and after Antidepressive Treatment

Multiple Hormone Responses to Stimulation with dl-Fenfluramine in Patients with Major Depression before and after Antidepressive Treatment

Serotonergic dysregulation in bipolar disorders: a literature review of serotonergic challenge studies

Serotoninergic Involvement in Gonadotropin and TSH Secretion in Normal Cycling and Postmenopausal Women

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